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Volume 24 Issue 3
June 2009
    Citation: Mei-li LI, Hong GUO, Qiong DING, Chun-fu ZHENG. A Multiple Functional Protein: the Herpes Simplex Virus Type 1 Tegument Protein VP22* .VIROLOGICA SINICA, 2009, 24(3) : 153-161.  http://dx.doi.org/10.1007/s12250-009-3035-2
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    A Multiple Functional Protein: the Herpes Simplex Virus Type 1 Tegument Protein VP22*

    cstr: 32224.14.s12250-009-3035-2

    • State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China

    • Corresponding author: Chun-fu ZHENG, zhengcf@wh.iov.cn
    • Equal contribution author
    • Received Date: 19 February 2009
      Accepted Date: 08 April 2009
      Available online: 01 June 2009

      Fund Project: Open Research Fund Program of the State Key Laboratory of Virology of China 2009007The Startup Fund of the Hundred Talents Program of the Chinese Academy of Science 20071010141National Natural Science Foundation of China 30870120Open Research Fund Program of the State Key Laboratory of Virology of China 2007003

    • The herpes simplex virus type 1 (HSV-1) VP22, is one of the most abundant HSV-1 tegument proteins with an average stoichiometry of 2 400 copies per virion and conserved among alphaherpesvirinae. Many functions are attributed to VP22, including nuclear localization, chromatin binding, microtubule binding, induction of microtubule reorganization, intercellular transport, interaction with cellular proteins, such as template activating factor I (TAF-I) and nonmuscle myosin II A (NMIIA), and viral proteins including tegument protein VP16, pUS9 and pUL46, glycoprotein E (gE) and gD. Recently, many novel functions performed by the HSV-1 VP22 protein have been shown, including promotion of protein synthesis at late times in infection, accumulation of a subset of viral mRNAs at early times in infection and possible transcriptional regulation function.
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      A Multiple Functional Protein: the Herpes Simplex Virus Type 1 Tegument Protein VP22*

        Corresponding author: Chun-fu ZHENG, zhengcf@wh.iov.cn
      • State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
      • Received Date: 19 February 2009
      • Accepted Date: 08 April 2009
      Fund Project:  Open Research Fund Program of the State Key Laboratory of Virology of China 2009007The Startup Fund of the Hundred Talents Program of the Chinese Academy of Science 20071010141National Natural Science Foundation of China 30870120Open Research Fund Program of the State Key Laboratory of Virology of China 2007003

      Abstract: The herpes simplex virus type 1 (HSV-1) VP22, is one of the most abundant HSV-1 tegument proteins with an average stoichiometry of 2 400 copies per virion and conserved among alphaherpesvirinae. Many functions are attributed to VP22, including nuclear localization, chromatin binding, microtubule binding, induction of microtubule reorganization, intercellular transport, interaction with cellular proteins, such as template activating factor I (TAF-I) and nonmuscle myosin II A (NMIIA), and viral proteins including tegument protein VP16, pUS9 and pUL46, glycoprotein E (gE) and gD. Recently, many novel functions performed by the HSV-1 VP22 protein have been shown, including promotion of protein synthesis at late times in infection, accumulation of a subset of viral mRNAs at early times in infection and possible transcriptional regulation function.

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