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Volume 26 Issue 6
December 2011
    Citation: Yan-bin Ma, Hui-yun Chang. Caspase Work Model During Pathogen Infection * .VIROLOGICA SINICA, 2011, 26(6) : 366-375.  http://dx.doi.org/10.1007/s12250-011-3218-5
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    Caspase Work Model During Pathogen Infection *

    • State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China

    • Corresponding author: Hui-yun Chang, changhuiyun@126.com
    • Received Date: 31 August 2011
      Accepted Date: 26 October 2011
      Available online: 01 December 2011

      Fund Project: The Fund of key special projects for breeding new varieties of genetically engineered organisms 2009 ZX08006-002BThe Fund of key special projects for breeding new varieties of genetically engineered organisms 2011ZX08011-004The Fund of key special projects for breeding new varieties of genetically engineered organisms 2009ZX08007-008B

    • Caspases are an evolutionarily conserved family of aspartate-specific cystein-dependent proteases with essential functions in apoptosis and normally exist in cells as inactive proenzymes. In addition to the inflammatory caspases, the initiator and effector caspases have been shown to have an important role in regulating the immune response, but are involved in different ways. We give a brief introduction on the benefit of apoptosis on the clearance of invasive pathogens, and the caspase functions involved in the immune response. Then we construct a working model of caspases during pathogen invasion. A detailed description of the three modes is given in the discussion. These three modes are regulated by different inhibitors, and there may be a novel way to treat intracellular pathogen and autoimmune diseases based on the specific inhibitors.
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      Caspase Work Model During Pathogen Infection *

        Corresponding author: Hui-yun Chang, changhuiyun@126.com
      • State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China
      • Received Date: 31 August 2011
      • Accepted Date: 26 October 2011
      Fund Project:  The Fund of key special projects for breeding new varieties of genetically engineered organisms 2009 ZX08006-002BThe Fund of key special projects for breeding new varieties of genetically engineered organisms 2011ZX08011-004The Fund of key special projects for breeding new varieties of genetically engineered organisms 2009ZX08007-008B

      Abstract: Caspases are an evolutionarily conserved family of aspartate-specific cystein-dependent proteases with essential functions in apoptosis and normally exist in cells as inactive proenzymes. In addition to the inflammatory caspases, the initiator and effector caspases have been shown to have an important role in regulating the immune response, but are involved in different ways. We give a brief introduction on the benefit of apoptosis on the clearance of invasive pathogens, and the caspase functions involved in the immune response. Then we construct a working model of caspases during pathogen invasion. A detailed description of the three modes is given in the discussion. These three modes are regulated by different inhibitors, and there may be a novel way to treat intracellular pathogen and autoimmune diseases based on the specific inhibitors.

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