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Volume 28 Issue 6
December 2013
    Citation: Manli Wang, Zhihong Hu. Bats as animal reservoirs for the SARS coronavirus: hypothesis proved after 10 years of virus hunting .VIROLOGICA SINICA, 2013, 28(6) : 315-317.  http://dx.doi.org/10.1007/s12250-013-3402-x
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    Bats as animal reservoirs for the SARS coronavirus: hypothesis proved after 10 years of virus hunting

    • State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China

    • Corresponding author: Zhihong Hu, huzh@wh.iov.cn
    • Received Date: 28 October 2013
      Accepted Date: 30 October 2013
      Published Date: 31 October 2013
      Available online: 01 December 2013
    • Recently, the team led by Dr. Zhengli Shi from Wuhan Institute of Virology, Chinese Academy of Sciences, and Dr. Peter Daszak from Ecohealth Alliance identified SL-CoVs in Chinese horseshoe bats that were 95% identical to human SARS-CoV and were able to use human angiotensin-converting enzyme 2 (ACE2) receptor for docking and entry. Remarkably, they isolated the first known live bat SL-CoV that replicates in human and related cells. Their findings provide clear evidence that some SL-CoVs circulating in bats are capable of infecting and replicating in human (Ge X Y, et al., 2013).
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      Bats as animal reservoirs for the SARS coronavirus: hypothesis proved after 10 years of virus hunting

        Corresponding author: Zhihong Hu, huzh@wh.iov.cn
      • State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
      • Received Date: 28 October 2013
      • Accepted Date: 30 October 2013
      • Published Date: 31 October 2013

      Abstract: Recently, the team led by Dr. Zhengli Shi from Wuhan Institute of Virology, Chinese Academy of Sciences, and Dr. Peter Daszak from Ecohealth Alliance identified SL-CoVs in Chinese horseshoe bats that were 95% identical to human SARS-CoV and were able to use human angiotensin-converting enzyme 2 (ACE2) receptor for docking and entry. Remarkably, they isolated the first known live bat SL-CoV that replicates in human and related cells. Their findings provide clear evidence that some SL-CoVs circulating in bats are capable of infecting and replicating in human (Ge X Y, et al., 2013).

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