Citation: Xiaojing Kuang, Lingling Sun, Shuzhen Liu, Zhenzhen Zhao, Danrui Zhao, Song Liu, Bing Luo. Association of single nucleotide polymorphism rs2065955 of the filaggrin gene with susceptibility to Epstein-Barr virus-associated gastric carcinoma and EBV-negative gastric carcinoma .VIROLOGICA SINICA, 2016, 31(4) : 306-313.  http://dx.doi.org/10.1007/s12250-016-3721-9

Association of single nucleotide polymorphism rs2065955 of the filaggrin gene with susceptibility to Epstein-Barr virus-associated gastric carcinoma and EBV-negative gastric carcinoma

  • Corresponding author: Bing Luo, qdluobing@163.com
  • Xiaojing Kuang, ORCID: 0000-0002-5675-8510
  • Received Date: 08 January 2016
    Accepted Date: 28 June 2016
    Published Date: 10 August 2016
    Available online: 01 August 2016
  • The relationship between the Filaggrin gene (FLG) rs2065955 polymorphism and susceptibility to Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) and EBV-negative gastric carcinoma (EBVnGC) was investigated in Shandong Province, China. We detected theFLG rs2065955 genotype and allele distribution by using PCR and restriction fragment length polymorphism (RFLP) in 64 EBVaGC, 82 EBVnGC, and 111 normal control samples. Immunohistochemistry was used to detect the level ofFLG protein in 35 EBVaGC and 51 EBVnGC tumor tissues. Compared with normal controls, the genotype CC and allele C ofFLG rs2065955 showed higher frequency in EBVaGC and EBVnGC. There was no significant difference between EBVaGC and EBVnGC in allele distribution ofFLG rs2065955, but the genotype CC was found more frequently in EBVaGC than in EBVnGC. The risk of developing either EBVaGC or EBVnGC in genotype CC was higher than in other genotypes. Furthermore, genotype CC ofFLG rs2065955 may contribute more to the risk of developing EBVaGC than EBVnGC. There was no significant difference in the expression level ofFLG protein between EBVaGC and EBVnGC. In conclusion, theFLG rs2065955 polymorphism was significantly related to gastric carcinoma. Allele C ofFLG rs2065955 could be a risk factor for EBVaGC or EBVnGC, while genotype CC ofFLG rs2065955 was especially associated with EBVaGC.

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    Association of single nucleotide polymorphism rs2065955 of the filaggrin gene with susceptibility to Epstein-Barr virus-associated gastric carcinoma and EBV-negative gastric carcinoma

      Corresponding author: Bing Luo, qdluobing@163.com
    • Xiaojing Kuang, ORCID: 0000-0002-5675-8510
    • 1. Department of Medical Microbiology, Qingdao University Medical College, Qingdao 266021, China
    • 2. Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China
    • 3. Department of Blood Transfusion, The Affiliated Hospital of Qingdao University, Qingdao 266003, China

    Abstract: The relationship between the Filaggrin gene (FLG) rs2065955 polymorphism and susceptibility to Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) and EBV-negative gastric carcinoma (EBVnGC) was investigated in Shandong Province, China. We detected theFLG rs2065955 genotype and allele distribution by using PCR and restriction fragment length polymorphism (RFLP) in 64 EBVaGC, 82 EBVnGC, and 111 normal control samples. Immunohistochemistry was used to detect the level ofFLG protein in 35 EBVaGC and 51 EBVnGC tumor tissues. Compared with normal controls, the genotype CC and allele C ofFLG rs2065955 showed higher frequency in EBVaGC and EBVnGC. There was no significant difference between EBVaGC and EBVnGC in allele distribution ofFLG rs2065955, but the genotype CC was found more frequently in EBVaGC than in EBVnGC. The risk of developing either EBVaGC or EBVnGC in genotype CC was higher than in other genotypes. Furthermore, genotype CC ofFLG rs2065955 may contribute more to the risk of developing EBVaGC than EBVnGC. There was no significant difference in the expression level ofFLG protein between EBVaGC and EBVnGC. In conclusion, theFLG rs2065955 polymorphism was significantly related to gastric carcinoma. Allele C ofFLG rs2065955 could be a risk factor for EBVaGC or EBVnGC, while genotype CC ofFLG rs2065955 was especially associated with EBVaGC.

    • Epstein-Barr virus (EBV), a well-known tumor-causing virus, is closely associated with several human lymphoid and epithelial tumors, such as Burkitt's lymphoma, Hodgkin's disease, AIDS-associated lymphoma, nasopha-ryngeal carcinoma, and gastric cancer (Thompson et al., 2004). In the last 20 years, the relationship between EBV infection and the occurrence of gastric carcinoma has been confirmed. EBV infection is found in 80%-100% of gastric lymphoepithelioma-like carcinoma cases and 2%-16% of ordinary gastric adenocarcinoma cases (Fukayama et al., 1994; Wu et al., 2000; Andal et al., 2003; Lee et al., 2004; ). The worldwide occurrence of EBV-associated gastric carcinoma (EBVaGC) is esti-mated at more than 50, 000 cases per year (Takada, 2000). Therefore, it is also widely accepted that EBVaGC is one of the most common cancers among EBV-related malignancies.

      The development of gastric cancer is a complex, multi-step process involving multiple genetic and epigenetic alterations in oncogenes, tumor suppressor genes, DNA repair genes, cell cycle regulators, and signaling mo-lecules (Nagini, 2012). Recognition of bacteria or viruses by the diversification level of the cytokine response and immune system is closely related to polymorphisms in host inflammatory response genes (Garza-gonzalez et al., 2005). Analysis of polymorphisms in genes related to the inflammatory response in the gastric mucosa and the associated risk for malignancy has been the central focus of many studies (Rad et al., 2009; Partida-rodriguez et al., 2010). However, little is known about the association of host gene polymorphisms with EBVaGC develop-ment.

      Filaggrin (FLG) is an intermediate-filament-associated protein that aggregates keratin intermediate filaments in the epidermis. It plays an important role in the function of skin as a barrier against invasion of harmful factors from the external environmental, including micro-organisms (Candi et al., 2005). Mutations in the FLG gene are associated with some skin disorders such as atopic dermatitis (Palmer et al., 2006) and ichthyosis vulgaris (Smith et al., 2006). A recent study found that loss-of-function mutations of FLG were closely associated with higher incidence of human papillomavirus (HPV)-related cancers and pre-cancers (Skaaby et al., 2014).

      In a previous study, we used a high-throughput sequencing method (RNA-Seq) to compare the transcript-omes of the gastric cancer cell lines AGS and AGS-EBV to determine the impact of EBV on gastric cancer and uncover clues to the tumorigenic mechanisms of EBV. The RNA-Seq results showed 929 single nucleotide polymorphisms (SNPs) between the two cell lines (Supplementary Table S1). There were 539 SNPs in intronic regions and 162 in exonic regions. Among those SNPs in exonic regions, 110 were synonymous mutations while 72 were nonsynonymous mutations. Of the 72 nonsy nonymous mutations, 25 SNPs were associated with tumors, and FLG rs2065955 was among them (Table 1). As considerable interest has arisen in the possible relationship between EBVaGC development and FLG gene polymorphisms, we looked for the FLG rs2065955 polymorphism in EBVaGC and EBV-negative gastric carcinoma (EBVnGC) tissues and tried to provide experimental evidence for genetic susceptibility to development of gastric carcinoma, especially EBVaGC.

      Table 1.  SNPs associate with tumors

    • One hundred and forty-six paraffin-embedded gastric carcinoma tissues, including 64 EBVaGC and 82 EBVnGC, were collected from the Department of Pathology of the Affiliated Hospital of Qingdao University, which is located in Shandong Province, northern China (Table 2; please check Supplementary Table S2 for more details). EBV-positive samples were determined by in situ hybridization for EBV-encoded small RNA 1 as described previously (Khan et al., 1992). One hundred and one healthy physical examinees from the Affiliated Hospital of Qingdao University were used as normal controls; 5 mL of fasting venous blood was collected using EDTA as an anticoagulant, and peripheral blood mononuclear cells were separated for DNA extraction. This study was approved by the Medical Ethics Committee of Qingdao University Medical College, and informed consent was obtained from all the study participants.

      Table 2.  Clinical characterizations of EBVaGC/EBVnGC patients and healthy controls

    • DNA of venous blood specimens was extracted by a standard method using proteinase K digestion and phe-nol-chloroform purification. A QIAamp DNA FFPE tissue kit (QIAGEN GmbH, Hilden, Germany) was used to extract the DNA from paraffin-embedded gastric carcinoma tissues.

    • PCR and restriction fragment length polymorphism (RFLP) were used to detect FLG rs2065955 located in the 25265th nucleotide of the FLG gene. Nucleotide substitution of G to C leads to an amino acid change from Gly to Ala in this mutation. Primers Forward (5′-CCAGACACTCAGGCATTC-3′) and Reverse (5′-CAATCGGTAGAATAGGTGG-3′) produced a PCR product of 436 bp.

      PCR reactions were performed with 2 μL of DNA extracts (100 ng/μL) in a 25 μL reaction mixture containing standard PCR buffer, 1.5 mmol/L MgCl2, 200 μmol/L dNTPs, 1.25 μmol/L of each primer, and 0.2 U Taq DNA polymerase (TaKaRa Biotechnology Co, Kyoto, Japan). Cycle conditions were pre-denaturation at 94 ℃ for 5 min, then 40 cycles of 94 ℃ for 30 s, 60 ℃ for 30 s, and 72 ℃ for 1 min, and final elongation at 72 ℃ for 10 min. The PCR products were separated on a 1.5% agarose gel. After electrophoresis, the gels were stained with ethidium bromide and photographed under a UV light transilluminator. Sterile double-distilled water was used as a negative control in each PCR reaction. PCR products were purified using a gel extraction kit (Qiaex Ⅱ; Qiagen) according to the manufacturer's instructions. Restriction enzymatic reactions were performed in a 25 μL mixture including 2.5 μL 10× buffer, 0.5 μL 10 U/μL ApaLI, 5 μL PCR product, and 17 μL enzyme-free double-distilled water. After incubation at 37 ℃ for 15 min, the DNA products were analyzed on a 2% agarose gel and then visualized by ethidium bromide staining.

    • Formalin-fixed, paraffin-embedded tissue slides (4 μm thick) were deparaffinized and rehydrated, and subjected to antigen retrieval, followed by blocking of endogenous peroxidase and treatment with a blocking reagent for nonspecific binding. Slides were then incubated over-night with the primary antibody, a rabbit polyclonal antibody against human FLG (1:500; ab24584; Abcam) at 4 ℃ in a humidified chamber. PBS was used as a negative control replacing the primary antibody.

      All immunohistochemistry evaluation was performed in a blinded manner by an attending pathologist. Specimens were graded by staining intensity (0: negative; 1: weak; 2: moderate; 3: strong) and the percentage of tumor cells (0: 0%-5%; 1: 6%-25%; 2: 26%-75%; 3: 76%-100%). The final score was calculated by multiplying these two variables. A score of 1-2 indicated weakly positive (1+), a score of 3-4 indicated moderately posi-tive (2+) and a score > 4 indicated intensely positive (3+).

    • The Chi-square test and Fisher's exact test were used to compare the differences in genotype and allele frequencies of FLG rs2065955 in each group. Nonconditional logistic regression was used to estimate the odds ratio (OR) and P values to indicate the correlation between genotype and the risk of gastric carcinoma. Results were considered to be statistically significant when P < 0.05. Statistical analyses were conducted using SPSS 19.0 sta-tistical software (SPSS, Chicago, IL).

    • The 436 bp fragments of the FLG gene flanking the rs2065955 locus were successfully amplified in 64 EBVaGC, 82 EBVnGC, and 111 normal control samples (Figure 1). After digestion by ApaLI, the homozygous wild-type genotype GG remained as only one 436 bp band. The homozygous mutant genotype CC showed two bands, 368bp and 68bp. The heterozygous genotype GC showed three bands, 368 bp, 68 bp, and 436 bp (Figure 2).

      Figure 1.  Electrophoresis results of FLG gene (rs2065955) PCR products. Lane M: DL 2000 DNA Marker; lane 16: negative control; lanes 1-15: 436 bp FLG (rs2065955) PCR products.

      Figure 2.  PCR-RFLP analysis of FLG gene (rs2065955) genotyping. Lane M: DL 2000 DNA Marker; lanes 1, 4, 7, 12, 15: GG genotype (homozygous wild-type); lanes 5, 6, 8, 9, 13, 14: GC genotype (heterozygous type); lanes 2, 3, 10, 11: CC genotype (homozygous mutated type).

      The distributions of FLG rs2065955 genotypes and alleles in EBVaGC, EBVnGC, and normal controls are shown in Table 3 and Table 4. The CC genotype was found in 38 of 64(59.4%) EBVaGC samples, 31 of 82(37.8%) EBVnGC samples, and 17 of 111(15.3%) normal controls. The distribution of the CC genotype was signifi-cantly different among the three groups (EBVaGC vs normal control: χ2 = 36.566, P < 0.01; EBVnGC vs normal control: χ2 = 12.766, P < 0.01; EBVaGC vs EBVnGC: χ2 = 6.701, P = 0.01). The CC genotype showed higher frequency in EBVaGC and EBVnGC than in normal controls and may be a risk factor for EBVaGC and EBVnGC (EBVaGC vs normal control: OR = 8.081, 95% CI = 3.941-16.571; EBVnGC vs normal control: OR = 3.361, 95% CI = 1.698-6.652; EBVaGC vs EBVnGC: OR = 2.404, 95% CI = 1.231-4.496).

      Table 3.  Genotype and allele frequencies of FLG (rs2065955) in EBVaGCs and EBVnGCs

      Table 4.  Distribution of genotype and allele of FLG in EBVaGC, EBVnGC, and control samples

      Allele C frequency was 70.3%, 61%, and 48.2% in EBVaGC, EBVnGC, and normal controls, respectively. Allele C exhibited higher frequency in EBVaGC and EBVnGC than in normal controls and may be a risk factor for EBVaGC and EBVnGC (EBVaGC vs normal control: χ2 = 16.137, P < 0.01, OR = 2.687, 95% CI = 1.683-4.289; EBVnGC vs normal control: χ2 = 6.192, P = 0.013, OR = 1.679, 95% CI = 1.698-6.652; EBVaGC vs EBVnGC: P = 0.097).

      FLG protein expression level in 35 EBVaGC and 51 EBVnGC tissue samples was detected by immunochemical methods (Table 5, Figure 3). The scoring criteria are mentioned in the MATERIALS AND METHODS section. The statistical analysis using Fisher's exact test showed that there was no significant difference in FLG protein expression level between EBVaGC and EBVnGC (P = 0.079).

      Table 5.  FLG protein expression level in EBVnGC and EBVaGC tissues

      Figure 3.  Immunohistochemical analysis of FLG. (A) FLG negative expression in tumor cells. (B) weakly positive (1+). (C) moderately positive (2+). The arrow indicates the specific cytoplasmic expression of FLG in gastric tumor cells. (Magnification: 100 ×)

    • In this study, we found that genotype CC of FLG showed higher frequency in gastric carcinoma, especially in EBVaGC, which may be a risk factor for EBVaGC development. To our knowledge, this is the first research describing the association of FLG polymorphism with EBV-associated diseases.

      Filaggrin proteins are crucial for the terminal differentiation of the epidermis by aggregating keratin filaments. They play important roles in the barrier function of skin, which may prevent the entry of harmful factors from environmental exposure including microorganisms, allergens, or chemicals (Candi et al., 2005). Loss-of-function mutations in the FLG gene reduce epidermal filaggrin levels and may disrupt the skin barrier, and have been shown to be highly associated with ichthyosis vulgaris (Smith et al., 2006) and atopic dermatitis (Palmer et al., 2006). In addition to the skin, filaggrin proteins are also expressed in the oral cavity, cervix, endometrium, and vagina (De benedetto et al., 2008; Irvine et al., 2011). FLG loss-of-function mutations also confer a higher risk of rhinitis, asthma, and food allergies in the context of atopic dermatitis (De benedetto et al., 2008). However, the role of filaggrin outside the skin is largely unknown.

      A few studies have reported the association of FLG mutations with the pathogenesis of certain carcinomas (Chen et al., 2013; Skaaby et al., 2014; Bager et al., 2015). Filaggrin expression was reported to be reduced in cervical lesions infected with HPV in a dose-depen-dent manner (Cintorino et al., 1988; Mcglennen et al., 1991; Lara et al., 1994). One report declared that FLG mutations were not associated with the risk of cervical cancer (Bager et al., 2015). However, Skaaby (2014) reported that FLG mutations led to greater susceptibility to infection by HPV and thus may confer a higher risk of HPV-related cancer and pre-cancer.

      We detected FLG rs2065955 in EBVaGC, EBVnGC, and normal controls. The association of this SNP with disease has not been reported previously. The distribution of the FLG gene SNP (rs2065955) was significantly different between the three groups. A higher proportion of genotype CC in gastric carcinoma (EBVaGC and EBVnGC) suggested that this genotype may be a risk factor for development of gastric carcinoma. A higher frequency of genotype CC in EBVaGC than in EBVnGC indicated that genotype CC may be associated with susceptibility to EBV infection and may contribute to the pathogenesis of EBVaGC. Despite significant diffe-rences in FLG rs2065955 polymorphism between EBVaGC and EBVnGC samples, there was no significant difference in FLG protein level between the two groups. To date, however, there have been no reports of EBV infection associated with FLG gene expression levels. A nucleotide mutation at one site only may affect the amino acid sequence of the encoded protein, but it does not necessarily cause changes in expression level. However, further work is needed to confirm this phenomenon. First, we have to confirm the expression of FLG in mucosa of the nose, oral cavity (the natural entrance of EBV to invade the human body), and stomach, which is the basis of the pathogenic role of FLG mutations. Second, a much larger-scale study of gastric carcinomas from different geographical regions should be undertaken to eliminate the possibility of sampling errors. Third, samples from other EBV-associated diseases such as nasopharyngeal carcinoma also should be included. In conclusion, our study found an interesting phenomenon in EBVaGC, which provides a new clue to tumorigenicity of EBV.

    • This study was funded by the National Natural Science Foundation of China (NSFC 81571995), Specialized Research Fund for the Doctoral Program of Higher Education, (20133706110001), and the Natural Science Founda-tion of Shandong Province (ZR2015HM069).

    • The authors declare that there is no conflict of interest. Additional informed consent was obtained from all patients for whom identifying information is included in this article.

    • BL and XK designed the experiments. XK, ZZZ, and DZ carried out the experiments. LS, SL, ZZZ, DZ, and SL analyzed the data. LS, XK, and BL wrote the paper. All authors have read and approved the final manuscript.

      Supplementary tables are available on the websites of Virologica Sinica: www.virosin.org; link.springer.com/journal/12250

    • ChromosomePositionReferenceRegionTranscript NameGene_idGene_nameAGS1_AGSAGS2_AGSAGSEBV1_AGSEBVAGSEBV2_AGSEBVAGS1_AGS(Synonymous/Non)AGS2_AGS(Synonymous/Non)AGSEBV1_AGSEBV(Synonymous/Non)AGSEBV2_AGSEBV(Synonymous/Non)rs_idRegulation
      chr110474430Aintronic----A->T; hom; QUAL=96.3;DP=5A->T; hom; QUAL=134;DP=10----rs35759975no
      chr1109513497CUTR3----C->T; hom; QUAL=140;DP=6C->T; hom; QUAL=32.8;DP=2----rs507776no
      chr1109606711Tintronic----T->C; het; QUAL=131;DP=29T->C; het; QUAL=3.01;DP=15----no rs idno
      chr111249132Gintronic----G->C; hom; QUAL=10.4;DP=1G->C; hom; QUAL=38.8;DP=2----rs1034528no
      chr1113233051Aintronic----A->G; het; QUAL=20;DP=8A->G; hom; QUAL=131;DP=9----no rs idno
      chr1113492862Cintronic----C->T; hom; QUAL=66;DP=3C->T; hom; QUAL=32.8;DP=2----rs4301628no
      chr1120163531TUTR3----T->C; het; QUAL=140;DP=45T->C; hom; QUAL=97.3;DP=5----rs10754416no
      chr112072518GUTR3----G->C; hom; QUAL=94.3;DP=5G->C; het; QUAL=75;DP=18----rs3088064no
      chr1121118830GncRNA_intronic----G->A; hom; QUAL=35.8;DP=2G->A; hom; QUAL=60;DP=3----rs140373583no
      chr11288823AUTR3----A->G; hom; QUAL=28.8;DP=2A->G; hom; QUAL=27.8;DP=2----rs2296471no
      chr11311378Tupstream----T->A; hom; QUAL=169;DP=18T->A; hom; QUAL=66;DP=3----rs2477776no
      chr11345556TncRNA_exonic----T->C; het; QUAL=46;DP=9T->C; hom; QUAL=133;DP=7----no rs idno
      chr11345583CncRNA_exonic----C->A; het; QUAL=37;DP=9C->A; hom; QUAL=136;DP=8----no rs idno
      chr11345645AncRNA_exonic----A->C; het; QUAL=44;DP=9A->C; hom; QUAL=173;DP=9----no rs idno
      chr1142688831CncRNA_exonic----C->A; hom; QUAL=42.8;DP=2C->A; hom; QUAL=104;DP=5----rs146967546no
      chr1143465106GncRNA_exonic----G->A; hom; QUAL=141;DP=10G->A; het; QUAL=4.77;DP=1----rs201950931no
      chr1143918910TncRNA_intronic----T->G; hom; QUAL=96.3;DP=5T->G; hom; QUAL=7.8;DP=1----rs374946176no
      chr1144053567CncRNA_exonic----C->T; het; QUAL=32;DP=5C->T; het; QUAL=9.52;DP=28----rs202144114no
      chr1144931087TexonicENST00000313431.9ENSG00000178104PDE4DIP--T->C; het; QUAL=143;DP=18T->C; het; QUAL=15.1;DP=9--nonsynonymous SNVnonsynonymous SNVrs41315684no
      chr1145101750GncRNA_intronic----G->A; hom; QUAL=98.5;DP=4G->A; hom; QUAL=80.5;DP=6----rs2596271no
      chr1145101767AncRNA_intronic----A->G; hom; QUAL=109;DP=4A->G; hom; QUAL=27.8;DP=2----rs2794064no
      chr1145282582TUTR3----T->G; hom; QUAL=14.2;DP=28T->G; het; QUAL=14.2;DP=12----rs1062341no
      chr1147094204GexonicENST00000234739.3ENSG00000116128BCL9--G->A; hom; QUAL=38.8;DP=2G->A; het; QUAL=104;DP=13--nonsynonymous SNVnonsynonymous SNVno rs idno
      chr1148181875Cintergenic----C->T; hom; QUAL=222;DP=30C->T; het; QUAL=174;DP=12----rs199585823no
      chr1149577065AncRNA_exonic----A->G; het; QUAL=4.77;DP=1A->G; hom; QUAL=94.3;DP=5----no rs idno
      chr1152005482CncRNA_intronic----C->G; hom; QUAL=94.1;DP=6C->G; het; QUAL=17.1;DP=16----rs2999550no
      chr1152161354TncRNA_intronic----T->C; hom; QUAL=7.8;DP=1T->C; hom; QUAL=122;DP=8----rs1390490no
      chr1152193052AexonicENST00000368801.2ENSG00000197915HRNR--A->G; hom; QUAL=132;DP=10A->G; hom; QUAL=172;DP=16--nonsynonymous SNVnonsynonymous SNVrs6587650no
      chr1152277055CexonicENST00000368799.1ENSG00000143631FLG--C->G; hom; QUAL=66;DP=3C->G; hom; QUAL=19.8;DP=2--stoploss SNVstoploss SNVrs2065955no
      chr1153497596Gintergenic----G->A; hom; QUAL=117;DP=6G->A; hom; QUAL=37;DP=14----rs7521972no
      chr1153585584Gupstream----G->A; het; QUAL=135;DP=15G->A; hom; QUAL=75.5;DP=4----rs9700179no
      chr1153608116Gintronic----G->C; hom; QUAL=7.8;DP=1G->C; het; QUAL=112;DP=8----rs28518786no
      chr1155174106CncRNA_intronic----C->T; het; QUAL=75;DP=7C->T; hom; QUAL=94.1;DP=8----rs386556537no
      chr1155294274AexonicENST00000368347.4ENSG00000160753RUSC1--A->G; hom; QUAL=119;DP=7A->G; hom; QUAL=122;DP=8--synonymous SNVsynonymous SNVrs914616no
      chr1155817788Tintronic----T->C; hom; QUAL=109;DP=9T->C; hom; QUAL=157;DP=10----rs11264417no
      chr1156716689Gintronic----G->A; hom; QUAL=118;DP=11G->A; hom; QUAL=74.5;DP=4----rs78365002no
      chr1160695906Cintergenic----C->T; hom; QUAL=7.8;DP=1C->T; het; QUAL=28;DP=14----rs500188no
      chr1160966393TUTR3----T->C; het; QUAL=81;DP=53T->C; het; QUAL=147;DP=40----rs1127844no
      chr1160966418TUTR3----T->C; het; QUAL=8.64;DP=31T->C; het; QUAL=80;DP=50----no rs idno
      chr1161403149Cintergenic----C->A; hom; QUAL=35.8;DP=2C->A; hom; QUAL=222;DP=16----rs191478200no
      chr1161736473Aintronic----A->G; hom; QUAL=68;DP=3A->G; hom; QUAL=169;DP=15----rs2271010no
      chr1161752479Tintronic----T->C; hom; QUAL=80.5;DP=4T->C; hom; QUAL=7.8;DP=1----rs2134692no
      chr1167514705Gintronic----G->A; hom; QUAL=80.5;DP=4G->A; hom; QUAL=28;DP=8----rs4657668no
      chr116840541Aupstream; downstream----A->G; het; QUAL=6.98;DP=13A->G; het; QUAL=92;DP=35----rs56140239no
      chr116840567Aupstream; downstream----A->G; het; QUAL=28;DP=14A->G; het; QUAL=146;DP=25----rs55869970no
      chr1175125036Cintergenic----C->T; hom; QUAL=157;DP=18C->T; hom; QUAL=103;DP=4----rs6425323no
      chr117541375Gintronic----G->A; hom; QUAL=164;DP=14G->A; het; QUAL=4.77;DP=1----rs143489722no
      chr117541390Gintronic----G->A; hom; QUAL=168;DP=14G->A; hom; QUAL=7.8;DP=1----no rs idno
      chr117550121GexonicENST00000375471.4ENSG00000142623PADI1--G->A; het; QUAL=225;DP=105G->A; het; QUAL=225;DP=63--synonymous SNVsynonymous SNVrs2293912no
      chr117550225Tintronic----T->C; hom; QUAL=46;DP=3T->C; hom; QUAL=171;DP=8----rs3003481no
      chr117550314Gintronic----G->A; hom; QUAL=113;DP=7G->A; hom; QUAL=35.8;DP=2----rs2293914no
      chr117550601Gintronic----G->A; hom; QUAL=168;DP=14G->A; hom; QUAL=222;DP=20----rs3003482no
      chr117552287Gintronic----G->A; hom; QUAL=130;DP=8G->A; hom; QUAL=147;DP=9----rs141463441no
      chr117555508GexonicENST00000375471.4ENSG00000142623PADI1--G->T; hom; QUAL=222;DP=78G->T; hom; QUAL=222;DP=41--synonymous SNVsynonymous SNVrs2977234no
      chr1179074599AUTR3----A->C; het; QUAL=29;DP=5A->C; het; QUAL=106;DP=10----rs117228532no
      chr1179263003GUTR5----G->A; hom; QUAL=103;DP=7G->A; hom; QUAL=87.5;DP=4----rs11545566no
      chr1180472298Cupstream----C->T; hom; QUAL=131;DP=10C->T; hom; QUAL=57;DP=3----rs3806301no
      chr1180947608Tintronic----T->G; hom; QUAL=182;DP=26T->G; hom; QUAL=10.4;DP=1----rs4652545no
      chr1183212171Cintronic----C->A; hom; QUAL=222;DP=27C->A; hom; QUAL=41.8;DP=2----rs3768594no
      chr1200959302GexonicENST00000332129.2ENSG00000116852KIF21B--G->A; hom; QUAL=153;DP=15G->A; hom; QUAL=222;DP=21--nonsynonymous SNVnonsynonymous SNVrs2297911no
      chr120238466AUTR3----A->G; hom; QUAL=222;DP=23A->G; het; QUAL=225;DP=55----rs17401847no
      chr1203766395TUTR5----T->C; hom; QUAL=158;DP=17T->C; hom; QUAL=221;DP=14----rs6693481no
      chr1204291443Gintronic----G->A; hom; QUAL=130;DP=9G->A; hom; QUAL=41.8;DP=2----rs12134661no
      chr1204520209CUTR3----C->T; hom; QUAL=98.5;DP=4C->T; hom; QUAL=222;DP=34----rs4951396no
      chr1205415817Cintronic----C->T; hom; QUAL=138;DP=11C->T; hom; QUAL=10.4;DP=1----rs913726no
      chr1206139240AUTR5----A->C; hom; QUAL=67.3;DP=5A->C; hom; QUAL=117;DP=6----no rs idno
      chr1207506649Cintronic----C->T; hom; QUAL=147;DP=9C->T; hom; QUAL=105;DP=6----rs11120733no
      chr1207519137Aintronic----A->G; hom; QUAL=63;DP=3A->G; hom; QUAL=222;DP=23----rs6673138no
      chr1207519231Gintronic----G->A; hom; QUAL=87.5;DP=4G->A; hom; QUAL=121;DP=7----rs1257727no
      chr1207522558Cintronic----C->T; hom; QUAL=38.8;DP=2C->T; hom; QUAL=35.8;DP=2----rs11120746no
      chr121084454Tintronic----T->C; hom; QUAL=10.4;DP=1T->C; hom; QUAL=68;DP=3----no rs idno
      chr121657769Cintronic----C->T; hom; QUAL=117;DP=6C->T; hom; QUAL=135;DP=14----rs213041no
      chr121657852Aintronic----A->G; hom; QUAL=106;DP=6A->G; hom; QUAL=168;DP=14----rs213042no
      chr1219377409Gintronic----G->T; hom; QUAL=154;DP=16G->T; hom; QUAL=96.1;DP=6----rs4846537no
      chr122209880Gintronic----G->A; hom; QUAL=96.3;DP=5G->A; hom; QUAL=132;DP=8----rs2454291no
      chr1224343762Cintronic----C->T; hom; QUAL=154;DP=10C->T; hom; QUAL=35.8;DP=2----rs6665085no
      chr1226369752Aintronic----A->G; hom; QUAL=89.5;DP=4A->G; hom; QUAL=27.8;DP=2----rs3008184no
      chr1227472964Aintronic----A->C; hom; QUAL=7.8;DP=1A->C; hom; QUAL=222;DP=18----rs16847582no
      chr1232564162TexonicENST00000262861.4ENSG00000116991SIPA1L2--T->C; het; QUAL=193;DP=22T->C; hom; QUAL=35.8;DP=2--nonsynonymous SNVnonsynonymous SNVrs34110867no
      chr12339115Tintronic----T->C; hom; QUAL=7.8;DP=1T->C; het; QUAL=4.77;DP=1----rs2494599no
      chr124110081Aintronic----A->G; hom; QUAL=222;DP=18A->G; hom; QUAL=60;DP=3----no rs idno
      chr1244823323Gintronic----G->C; hom; QUAL=10.4;DP=1G->C; hom; QUAL=147;DP=9----rs6687556no
      chr1244927751Gintergenic----G->A; het; QUAL=18.1;DP=19G->A; hom; QUAL=7.8;DP=1----rs1807991no
      chr1246431930Tintronic----T->C; hom; QUAL=155;DP=10T->C; hom; QUAL=10.4;DP=1----no rs idno
      chr1246651577Aintronic----A->G; hom; QUAL=10.4;DP=1A->G; hom; QUAL=146;DP=10----rs12567142no
      chr1247216831Aintronic----A->G; hom; QUAL=41.8;DP=2A->G; hom; QUAL=222;DP=12----rs6426213no
      chr124970138CUTR5----C->G; hom; QUAL=80.5;DP=4C->G; hom; QUAL=35.8;DP=2----rs61773957no
      chr128285825AncRNA_intronic----A->C; hom; QUAL=222;DP=16A->C; hom; QUAL=46;DP=3----rs4908383no
      chr129443675TUTR3----T->C; het; QUAL=36;DP=33T->C; het; QUAL=98;DP=23----rs502393no
      chr13543799Aintronic----A->G; hom; QUAL=122;DP=8A->G; hom; QUAL=35.8;DP=2----no rs idno
      chr136826859AexonicENST00000359297.2ENSG00000196182STK40--A->C; hom; QUAL=10.4;DP=1A->C; het; QUAL=59;DP=11--nonsynonymous SNVnonsynonymous SNVno rs iddown
      chr139919467AexonicENST00000361689.2ENSG00000127603MACF1--A->G; het; QUAL=16.1;DP=5A->G; het; QUAL=53;DP=40--nonsynonymous SNVnonsynonymous SNVno rs idno
      chr143419354Cintronic----C->A; hom; QUAL=137;DP=10C->A; het; QUAL=130;DP=22----rs3768043no
      chr145266606AexonicENST00000372201.4ENSG00000173846PLK3--A->T; het; QUAL=85;DP=11A->G; het; QUAL=49;DP=22--nonsynonymous SNVnonsynonymous SNVno rs idno
      chr153771861CncRNA_exonic----C->T; hom; QUAL=102;DP=5C->T; hom; QUAL=134;DP=11----rs1288491no
      chr160338776AUTR3----A->G; het; QUAL=175;DP=35A->G; hom; QUAL=154;DP=10----rs11207530no
      chr161596556Cintronic----C->T; hom; QUAL=118;DP=7C->T; het; QUAL=85;DP=15----rs17121650no
      chr165403109Aintronic----A->G; hom; QUAL=122;DP=8A->G; hom; QUAL=63;DP=3----rs11208549no
      chr170904800GexonicENST00000346806.2ENSG00000116761CTH--G->T; hom; QUAL=222;DP=14G->T; het; QUAL=153;DP=12--nonsynonymous SNVnonsynonymous SNVrs1021737no
      chr17833228AUTR5----A->G; hom; QUAL=45.8;DP=2A->G; hom; QUAL=32.8;DP=2----rs34177663no
      chr17904475GUTR3----G->A; hom; QUAL=175;DP=16G->A; hom; QUAL=10.4;DP=1----rs228678no
      chr18418644CexonicENST00000476556.1ENSG00000142599RERE--C->A; het; QUAL=4.77;DP=2C->A; hom; QUAL=60;DP=3--nonsynonymous SNVnonsynonymous SNVrs386628264no
      chr18418650TexonicENST00000377464.1ENSG00000142599RERE--T->C; hom; QUAL=10.4;DP=1T->C; hom; QUAL=68;DP=3--synonymous SNVsynonymous SNVrs1058766no
      chr185025945TncRNA_intronic----T->C; hom; QUAL=222;DP=24T->C; hom; QUAL=38.8;DP=2----rs59898877no
      chr18871690Gintronic----G->A; hom; QUAL=177;DP=20G->A; hom; QUAL=64.5;DP=4----rs7520572no
      chr1891021Gintronic----G->A; hom; QUAL=10.4;DP=1G->A; hom; QUAL=20.8;DP=2----rs13302957no
      chr189422472Tintronic----T->G; hom; QUAL=35.8;DP=2T->G; hom; QUAL=42.8;DP=2----rs10922528no
      chr19162243TUTR3----T->C; het; QUAL=85;DP=9T->C; hom; QUAL=166;DP=13----no rs idno
      chr19231624TncRNA_intronic----T->C; het; QUAL=92;DP=22T->C; het; QUAL=32;DP=20----no rs idno
      chr192795104Cintronic----C->T; hom; QUAL=96.3;DP=5C->T; hom; QUAL=145;DP=6----rs79491239no
      chr10101380968TncRNA_exonic----T->C; hom; QUAL=32.8;DP=2T->C; hom; QUAL=35.8;DP=2----rs2297448no
      chr10102764511Gintronic----G->A; hom; QUAL=41.8;DP=2G->A; hom; QUAL=7.8;DP=1----rs386615202no
      chr10102764895Aintronic----A->G; hom; QUAL=38.8;DP=2A->G; het; QUAL=207;DP=14----no rs idno
      chr10111793850Gintronic----G->A; het; QUAL=4.77;DP=1G->A; hom; QUAL=48.8;DP=2----rs7073105no
      chr10114481070Gintronic----G->A; hom; QUAL=24.8;DP=2G->A; het; QUAL=26;DP=4----rs963460no
      chr10114754714Cintronic----C->A; hom; QUAL=35.8;DP=2C->A; hom; QUAL=49;DP=3----no rs idno
      chr10120924651Aintronic----A->T; hom; QUAL=129;DP=8A->T; hom; QUAL=36.8;DP=2----rs11198807no
      chr10126490947Cintronic----C->T; hom; QUAL=112;DP=9C->T; hom; QUAL=154;DP=14----rs2683598no
      chr10128601941Cintronic----C->T; hom; QUAL=7.8;DP=1C->T; hom; QUAL=32.8;DP=2----rs7076163no
      chr1014589786Aintronic----A->T; hom; QUAL=99.5;DP=4A->T; het; QUAL=4.77;DP=1----rs72768915no
      chr1027799309Gintronic----G->C; het; QUAL=91;DP=8G->C; hom; QUAL=7.8;DP=1----rs12356076no
      chr103203498TncRNA_intronic----T->C; hom; QUAL=159;DP=15T->C; hom; QUAL=135;DP=9----rs7900718no
      chr1032186783Aintronic----A->G; hom; QUAL=122;DP=7A->G; hom; QUAL=38.8;DP=2----rs2491272no
      chr1033196703Tintronic----T->C; hom; QUAL=121;DP=7T->C; hom; QUAL=20.8;DP=2----rs2488319no
      chr103816180Cintergenic----C->T; hom; QUAL=96.5;DP=4C->T; hom; QUAL=38.8;DP=2----rs10795075no
      chr1038692597Gupstream----G->A; hom; QUAL=32.8;DP=2G->A; hom; QUAL=45.8;DP=2----rs2804634no
      chr1043636800Gintronic----G->A; hom; QUAL=60;DP=3G->A; hom; QUAL=54.5;DP=4----rs192309683no
      chr105727202Cintronic----C->T; hom; QUAL=145;DP=9C->T; hom; QUAL=54;DP=3----rs7091641no
      chr105783167AncRNA_intronic----A->G; hom; QUAL=7.8;DP=1A->G; hom; QUAL=130;DP=7----rs2797487no
      chr1062478269Gintronic----G->A; hom; QUAL=104;DP=6G->A; hom; QUAL=102;DP=5----rs16915422no
      chr1070095443Gintronic----G->A; hom; QUAL=222;DP=17G->A; hom; QUAL=7.8;DP=1----rs386520369no
      chr1071561770GUTR5----G->A; hom; QUAL=88;DP=15G->A; hom; QUAL=139;DP=8----rs386572283no
      chr1071562437GexonicENST00000479733.1ENSG00000197467COL13A1--G->A; hom; QUAL=38.8;DP=2G->A; hom; QUAL=7.8;DP=9--synonymous SNVsynonymous SNVrs10998973no
      chr1071678058CexonicENST00000479733.1ENSG00000197467COL13A1--C->G; hom; QUAL=50;DP=3C->G; hom; QUAL=156;DP=12--synonymous SNVsynonymous SNVrs2274181no
      chr1071690584Cintronic----C->A; hom; QUAL=106;DP=12C->A; hom; QUAL=222;DP=22----rs2763340no
      chr1075276742TexonicENST00000394811.2ENSG00000166348USP54--T->C; hom; QUAL=7.8;DP=1T->C; hom; QUAL=53;DP=3--nonsynonymous SNVnonsynonymous SNVrs141936153no
      chr1075836133Gintronic----G->T; hom; QUAL=180;DP=21G->T; hom; QUAL=129;DP=8----rs2934773no
      chr1079566632GexonicENST00000424842.1ENSG00000151208DLG5--G->A; hom; QUAL=66;DP=3G->A; hom; QUAL=117;DP=10--nonsynonymous SNVnonsynonymous SNVrs1058198no
      chr1081961021Cintronic----C->T; hom; QUAL=66;DP=3C->T; hom; QUAL=23.8;DP=2----rs2819941no
      chr1088722398AexonicENST00000348795.4ENSG00000173267SNCG--A->T; hom; QUAL=120;DP=6A->T; het; QUAL=110;DP=19--stoploss SNVstoploss SNVrs9864no
      chr1089269267Gintronic----G->A; hom; QUAL=35.8;DP=2G->A; hom; QUAL=155;DP=10----rs3843598no
      chr1089675590Gintronic----G->C; hom; QUAL=80.5;DP=4G->C; hom; QUAL=66;DP=3----rs1234223no
      chr1094714427CexonicENST00000260762.6ENSG00000138190EXOC6--C->G; het; QUAL=3.54;DP=2C->G; hom; QUAL=91.3;DP=5--nonsynonymous SNVnonsynonymous SNVrs11187225no
      chr1096325191Aintronic----A->G; hom; QUAL=38.8;DP=2A->G; hom; QUAL=7.8;DP=1----no rs idno
      chr1097804167AexonicENST00000465148.2ENSG00000107443CCNJ--A->T; het; QUAL=56;DP=13A->T; het; QUAL=5.46;DP=9--nonsynonymous SNVnonsynonymous SNVno rs idno
      chr1099504630GexonicENST00000356257.4ENSG00000155256ZFYVE27--G->T; hom; QUAL=41.8;DP=2G->T; hom; QUAL=222;DP=20--nonsynonymous SNVnonsynonymous SNVrs10882993no
      chr11102105605Aintergenic----A->G; hom; QUAL=80;DP=15A->G; hom; QUAL=22;DP=3----rs2846837no
      chr11102105673Aintergenic----A->G; hom; QUAL=156;DP=15A->G; hom; QUAL=35.8;DP=3----rs2846836no
      chr11107716874Gintronic----G->A; hom; QUAL=35.8;DP=2G->A; hom; QUAL=60;DP=3----rs10890769no
      chr11121418806Cintronic----C->T; hom; QUAL=7.8;DP=1C->T; hom; QUAL=7.8;DP=1----rs7103597no
      chr1112191093Cintronic----C->T; hom; QUAL=98.5;DP=4C->T; hom; QUAL=7.8;DP=1----rs11022221no
      chr1112191162Cintronic----C->A; hom; QUAL=35.8;DP=2C->A; hom; QUAL=7.8;DP=1----rs10831745no
      chr11129142636Aintronic----A->G; hom; QUAL=16.1;DP=21A->G; hom; QUAL=175;DP=10----rs11221630no
      chr11129948489Tintronic----T->G; hom; QUAL=144;DP=9T->G; hom; QUAL=66;DP=3----rs58488415no
      chr11131646478Tintronic----T->A; hom; QUAL=127;DP=11T->A; hom; QUAL=45.8;DP=2----rs10894443no
      chr1117537033Aintronic----A->G; hom; QUAL=45.8;DP=2A->G; hom; QUAL=98.1;DP=6----rs7119876no
      chr1117550138Tintronic----T->C; hom; QUAL=167;DP=24T->C; hom; QUAL=141;DP=10----rs2108333no
      chr1118428166GncRNA_intronic----G->A; hom; QUAL=7.8;DP=1G->A; hom; QUAL=80.5;DP=4----rs10766476no
      chr1128352603AUTR3----A->G; hom; QUAL=142;DP=8A->G; hom; QUAL=196;DP=8----rs144938816no
      chr112936434Gintronic----G->A; hom; QUAL=118;DP=16G->A; hom; QUAL=128;DP=8----rs450876no
      chr113041195Gintronic----G->A; hom; QUAL=101;DP=7G->A; hom; QUAL=32.8;DP=2----rs2106229no
      chr113067687Gintronic----G->T; hom; QUAL=144;DP=10G->T; hom; QUAL=60;DP=3----rs3782077no
      chr113073838Aintronic----A->T; hom; QUAL=41.8;DP=2A->T; het; QUAL=4.77;DP=1----rs2290000no
      chr113075348Gintronic----G->A; hom; QUAL=7.8;DP=1G->A; hom; QUAL=94.3;DP=5----rs6578319no
      chr113076257CUTR5----C->T; hom; QUAL=157;DP=16C->T; hom; QUAL=170;DP=14----rs7945933no
      chr1133149185Tintronic----T->C; hom; QUAL=38.8;DP=2T->C; hom; QUAL=63;DP=3----rs3117652no
      chr1134929051Tintronic----T->C; hom; QUAL=144;DP=6T->C; hom; QUAL=87.5;DP=4----rs2025777no
      chr1146589518Tintronic----T->C; hom; QUAL=7.8;DP=2T->C; hom; QUAL=28.8;DP=2----no rs idno
      chr1146599390Gintronic----G->C; het; QUAL=4.77;DP=1G->C; hom; QUAL=169;DP=15----rs4752802no
      chr1147259668Tintronic----T->C; hom; QUAL=106;DP=7T->C; hom; QUAL=109;DP=4----rs326222no
      chr1147331116TexonicENST00000402799.1ENSG00000110514MADD--T->C; hom; QUAL=161;DP=7T->C; hom; QUAL=222;DP=17--synonymous SNVsynonymous SNVrs1017594down
      chr1147648042Gintronic----G->A; hom; QUAL=66;DP=3G->A; hom; QUAL=150;DP=9----rs4752856no
      chr1157561106Gintronic----G->T; hom; QUAL=35.8;DP=2G->T; hom; QUAL=7.8;DP=1----rs386597260no
      chr1161717607CUTR5----C->T; het; QUAL=4.77;DP=1C->T; het; QUAL=36;DP=10----rs972354no
      chr1161914369CexonicENST00000394818.3ENSG00000149503INCENP--C->T; hom; QUAL=137;DP=8C->T; het; QUAL=4.77;DP=1--synonymous SNVsynonymous SNVrs35595038no
      chr1164572557AexonicENST00000315422.4ENSG00000133895MEN1--A->G; hom; QUAL=7.8;DP=1A->G; hom; QUAL=154;DP=8--stoploss SNVstoploss SNVrs540012no
      chr1164977424Cintronic----C->T; hom; QUAL=164;DP=17C->T; hom; QUAL=216;DP=14----rs2271448no
      chr1165207472AncRNA_exonic----A->G; het; QUAL=134;DP=18A->G; hom; QUAL=7.8;DP=1----no rs idno
      chr1165628334GexonicENST00000529857.1ENSG00000172732MUS81--G->A; hom; QUAL=79.3;DP=5G->A; hom; QUAL=35.8;DP=2--nonsynonymous SNVnonsynonymous SNVrs13817no
      chr1165667149Cintronic----C->G; hom; QUAL=119;DP=7C->G; hom; QUAL=146;DP=11----rs10160792no
      chr1165683513Adownstream----A->G; hom; QUAL=129;DP=11A->G; hom; QUAL=96.5;DP=4----rs9326359no
      chr1165683531Adownstream----A->G; hom; QUAL=222;DP=17A->G; hom; QUAL=142;DP=6----rs677029no
      chr1166138894Gintronic----G->C; hom; QUAL=131;DP=10G->C; hom; QUAL=179;DP=9----rs7946434no
      chr1167370922AUTR3----A->C; hom; QUAL=38.8;DP=2A->C; hom; QUAL=7.8;DP=1----no rs idno
      chr1167371007CUTR3----C->T; hom; QUAL=32.8;DP=2C->T; hom; QUAL=7.8;DP=1----no rs idno
      chr1167371425AUTR3----A->C; hom; QUAL=31;DP=41A->C; het; QUAL=225;DP=34----no rs idno
      chr1167371498CUTR3----C->T; hom; QUAL=36;DP=41C->T; hom; QUAL=179;DP=19----no rs idno
      chr1168118563Tintronic----T->C; hom; QUAL=10.4;DP=1T->C; hom; QUAL=34.8;DP=2----rs312783no
      chr11714980TncRNA_intronic----T->C; hom; QUAL=66;DP=3T->C; hom; QUAL=59;DP=3----rs12361811no
      chr1186644746Gintronic----G->C; hom; QUAL=159;DP=16G->C; hom; QUAL=10.4;DP=1----rs3740666no
      chr11881651Aintronic----A->G; hom; QUAL=136;DP=9A->G; hom; QUAL=121;DP=7----rs7125283no
      chr11881656Tintronic----T->G; hom; QUAL=136;DP=9T->G; hom; QUAL=126;DP=7----rs7121430no
      chr1193468094Tintronic----T->C; het; QUAL=135;DP=41T->C; hom; QUAL=7.8;DP=1----rs1063080no
      chr12104325725Aintronic----A->G; hom; QUAL=152;DP=11A->G; hom; QUAL=119;DP=6----rs10778306no
      chr12104326991Aintronic----A->G; hom; QUAL=10.4;DP=1A->G; hom; QUAL=7.8;DP=1----rs1920413no
      chr12104512918TUTR3----T->G; hom; QUAL=222;DP=14T->G; het; QUAL=29;DP=3----rs2466551no
      chr12104735120Gintronic----G->A; hom; QUAL=222;DP=34G->A; hom; QUAL=169;DP=9----rs76462012no
      chr121056822Aintronic----A->G; hom; QUAL=7.8;DP=1A->G; hom; QUAL=27.8;DP=2----rs10744730no
      chr12106741767Cdownstream----C->T; hom; QUAL=10.4;DP=1C->T; hom; QUAL=168;DP=36----rs10861579no
      chr12107354037Tintronic----T->C; hom; QUAL=222;DP=20T->C; hom; QUAL=27.8;DP=2----rs2374652no
      chr12107367224TUTR3----T->C; hom; QUAL=41.8;DP=2T->C; hom; QUAL=207;DP=11----rs367981842no
      chr12107367225TUTR3----T->C; hom; QUAL=41.8;DP=2T->C; hom; QUAL=203;DP=10----rs1053051no
      chr12120491235Tintronic----T->C; hom; QUAL=37;DP=9T->C; hom; QUAL=10.4;DP=1----rs78555544no
      chr12123342229Aintronic----A->G; hom; QUAL=136;DP=8A->G; hom; QUAL=131;DP=7----rs1587856no
      chr12124887096TexonicENST00000405201.1ENSG00000196498NCOR2--T->C; het; QUAL=102;DP=16T->C; hom; QUAL=10.4;DP=1--nonsynonymous SNVnonsynonymous SNVrs28690647no
      chr12124913449Cintronic----C->G; hom; QUAL=41.8;DP=2C->G; hom; QUAL=57;DP=3----rs1244094no
      chr12125398517GUTR5----G->A; hom; QUAL=42.8;DP=2G->A; hom; QUAL=222;DP=15----rs2070628no
      chr12127650639AncRNA_exonic----A->G; het; QUAL=47;DP=206A->G; het; QUAL=9.52;DP=11----rs61936129no
      chr1213067528TUTR3----T->C; het; QUAL=83;DP=24T->C; het; QUAL=14.2;DP=18----rs10845669no
      chr1213069412TUTR3----T->C; het; QUAL=226;DP=48T->C; het; QUAL=95;DP=78----rs140098634no
      chr12133339417Tupstream----T->C; hom; QUAL=10.4;DP=1T->C; hom; QUAL=87.5;DP=4----rs11147064no
      chr1214922909Cintronic----C->A; het; QUAL=125;DP=11C->A; het; QUAL=25;DP=5----rs16910241no
      chr1227161525Tintronic----T->C; hom; QUAL=119;DP=6T->C; hom; QUAL=87.5;DP=4----rs7299556no
      chr123049631CUTR3----C->T; hom; QUAL=159;DP=19C->T; hom; QUAL=152;DP=11----rs2302282no
      chr1232563932Tintronic----T->C; hom; QUAL=150;DP=10T->C; hom; QUAL=23.8;DP=2----rs11051991no
      chr1248458987TexonicENST00000448372.1ENSG00000079387SENP1--T->C; hom; QUAL=130;DP=13T->C; hom; QUAL=67.5;DP=4--nonsynonymous SNVnonsynonymous SNVno rs idno
      chr1250452708CexonicENST00000228468.4ENSG00000110881ASIC1--C->G; hom; QUAL=27.8;DP=2C->G; hom; QUAL=99.3;DP=5--synonymous SNVsynonymous SNVrs653576no
      chr1250538835TexonicENST00000550899.1ENSG00000139624CERS5--T->C; hom; QUAL=45.8;DP=2T->C; het; QUAL=85;DP=9--synonymous SNVsynonymous SNVno rs idno
      chr1251515116Tintronic----T->C; hom; QUAL=87.5;DP=4T->C; hom; QUAL=35.8;DP=2----no rs idno
      chr1251515126Tintronic----T->C; hom; QUAL=87.5;DP=4T->C; hom; QUAL=35.8;DP=2----no rs idno
      chr1253297594Cintronic----C->G; hom; QUAL=146;DP=9C->G; hom; QUAL=60;DP=3----rs4919703no
      chr1262916144Gintronic----G->T; hom; QUAL=41.8;DP=2G->T; hom; QUAL=32.8;DP=2----rs4763023no
      chr129449147GncRNA_intronic----G->A; hom; QUAL=142;DP=10G->A; hom; QUAL=102;DP=5----rs201015886no
      chr129449306CncRNA_intronic----C->A; hom; QUAL=165;DP=20C->A; hom; QUAL=105;DP=9----rs200293858no
      chr1297346924GUTR3----G->A; hom; QUAL=180;DP=21G->A; hom; QUAL=35.8;DP=2----rs1044910no
      chr13108871489Gintronic----G->T; hom; QUAL=96.3;DP=5G->T; hom; QUAL=35.8;DP=2----rs12428136no
      chr13110850842AexonicENST00000543140.1ENSG00000187498COL4A1--A->G; hom; QUAL=11.1;DP=2A->G; hom; QUAL=222;DP=29--synonymous SNVsynonymous SNVrs995224no
      chr13113373431Tintronic----T->C; hom; QUAL=222;DP=19T->C; hom; QUAL=158;DP=11----rs282566no
      chr13113439586Gintronic----G->T; hom; QUAL=60;DP=3G->T; het; QUAL=103;DP=9----rs11616475no
      chr13113509919Aintronic----A->G; hom; QUAL=38.8;DP=2A->G; hom; QUAL=107;DP=5----rs3742230no
      chr13113528499Aintronic----A->C; hom; QUAL=174;DP=17A->C; hom; QUAL=89.5;DP=4----rs386774994no
      chr13113528501Cintronic----C->G; hom; QUAL=175;DP=17C->G; hom; QUAL=89.5;DP=4----rs9549594no
      chr13113673400Cintronic----C->T; hom; QUAL=143;DP=8C->T; hom; QUAL=136;DP=6----rs3011522no
      chr13113911651Cintronic----C->T; hom; QUAL=163;DP=22C->T; hom; QUAL=94.3;DP=5----rs12876365no
      chr1320657286Tintronic----T->G; hom; QUAL=222;DP=40T->G; hom; QUAL=113;DP=7----rs9509029no
      chr1320657312Cintronic----C->G; hom; QUAL=222;DP=40C->G; hom; QUAL=214;DP=14----rs9509030no
      chr1320763642CexonicENST00000382844.1ENSG00000165474GJB2--C->T; hom; QUAL=92.3;DP=5C->T; hom; QUAL=7.8;DP=2--nonsynonymous SNVnonsynonymous SNVrs2274084no
      chr1321465920Tintronic----T->G; hom; QUAL=147;DP=11T->G; hom; QUAL=35.8;DP=2----rs9509421no
      chr1321948577Tintergenic----T->C; het; QUAL=3.54;DP=3T->C; het; QUAL=102;DP=29----no rs idno
      chr1328003362Cintronic----C->G; hom; QUAL=94.5;DP=4C->G; het; QUAL=4.77;DP=1----rs1237710no
      chr1328241061TUTR3----T->C; hom; QUAL=38.8;DP=2T->C; hom; QUAL=63;DP=3----rs11149483no
      chr1331711857Tintronic----T->G; hom; QUAL=70.5;DP=4T->G; hom; QUAL=134;DP=8----rs4941761no
      chr1337551898Tintronic----T->C; hom; QUAL=161;DP=11T->C; hom; QUAL=128;DP=7----no rs idno
      chr1339621275AexonicENST00000379600.3ENSG00000188811NHLRC3--A->C; hom; QUAL=94.1;DP=6A->G; het; QUAL=41;DP=4--synonymous SNVsynonymous SNVno rs idno
      chr1341384489Aupstream; downstream----A->G; hom; QUAL=69;DP=3A->G; hom; QUAL=41.8;DP=2----no rs idno
      chr1342809276Gintergenic----G->C; hom; QUAL=152;DP=6G->C; het; QUAL=75;DP=11----rs1449505no
      chr1346096012Aintronic----A->G; hom; QUAL=160;DP=12A->G; hom; QUAL=45.8;DP=2----no rs idno
      chr1349735653Aintronic----A->G; hom; QUAL=122;DP=6A->G; het; QUAL=4.77;DP=1----rs78001263no
      chr1352515354AexonicENST00000418097.2ENSG00000123191ATP7B--A->G; hom; QUAL=146;DP=14A->G; het; QUAL=51;DP=13--stoploss SNVstoploss SNVrs1801249no
      chr1373653881Tintergenic----T->C; hom; QUAL=222;DP=44T->C; hom; QUAL=87.5;DP=4----rs4883922no
      chr1376410725Aintronic----A->G; hom; QUAL=94.5;DP=4A->G; hom; QUAL=116;DP=7----rs2273996no
      chr1392015525Gintergenic----G->A; hom; QUAL=45.8;DP=2G->A; het; QUAL=4.77;DP=1----rs17667900no
      chr1398002508Gintronic----G->A; het; QUAL=225;DP=41G->A; hom; QUAL=222;DP=16----rs7318250no
      chr1398002623Gintronic----G->C; hom; QUAL=175;DP=17G->C; hom; QUAL=92.3;DP=5----rs9584559no
      chr1398007015Aintronic----A->G; hom; QUAL=222;DP=19A->G; hom; QUAL=38.8;DP=2----rs6491350no
      chr1399207711Tintronic----T->C; hom; QUAL=162;DP=18T->C; hom; QUAL=85.5;DP=4----no rs idno
      chr14103073525Cintronic----C->G; hom; QUAL=99.5;DP=4C->G; hom; QUAL=35.8;DP=2----rs2403067no
      chr14103073533Gintronic----G->A; hom; QUAL=103;DP=4G->A; hom; QUAL=28.8;DP=2----rs2403068no
      chr14103804720AexonicENST00000558265.1ENSG00000100664EIF5--A->G; hom; QUAL=28.8;DP=2A->G; het; QUAL=48;DP=22--nonsynonymous SNVnonsynonymous SNVno rs idup
      chr1423303293Tintronic----T->G; hom; QUAL=68;DP=3T->G; hom; QUAL=10.4;DP=1----rs12437230no
      chr1431795548TexonicENST00000439348.1ENSG00000129493HEATR5A--T->C; het; QUAL=49;DP=5T->C; het; QUAL=100;DP=14--stopgain SNVstopgain SNVno rs idno
      chr1431855629TexonicENST00000439348.1ENSG00000129493HEATR5A--T->A; hom; QUAL=7.8;DP=1T->A; hom; QUAL=45.8;DP=2--stopgain SNVstopgain SNVno rs idno
      chr1435496029Aintronic----A->G; hom; QUAL=222;DP=23A->G; hom; QUAL=123;DP=9----no rs idno
      chr1435683426Aintronic----A->G; hom; QUAL=30.8;DP=2A->G; hom; QUAL=91;DP=8----rs12589317no
      chr1439844119Aintronic----A->G; hom; QUAL=159;DP=11A->G; hom; QUAL=222;DP=14----rs8014839no
      chr1453130507TexonicENST00000554019.1ENSG00000197930ERO1L--T->C; hom; QUAL=7.8;DP=1T->C; hom; QUAL=45.8;DP=2--nonsynonymous SNVnonsynonymous SNVrs17125636no
      chr1454552557Gintergenic----G->A; hom; QUAL=162;DP=11G->A; het; QUAL=89;DP=8----rs1957641no
      chr1454630278Aintergenic----A->G; hom; QUAL=181;DP=24A->G; het; QUAL=30;DP=20----rs2358478no
      chr1454661615Tintergenic----T->C; hom; QUAL=20.8;DP=2T->C; hom; QUAL=81.5;DP=4----rs8011813no
      chr1454681823Tintergenic----T->C; hom; QUAL=7.8;DP=1T->C; het; QUAL=29;DP=3----no rs idno
      chr1474428445GexonicENST00000238709.4ENSG00000119723COQ6--G->A; hom; QUAL=85.5;DP=4G->A; het; QUAL=3.02;DP=1--nonsynonymous SNVnonsynonymous SNVrs8500no
      chr1477930752Gintronic----G->A; hom; QUAL=10.4;DP=1G->A; hom; QUAL=41.8;DP=2----rs11624314no
      chr1492582528AUTR3----A->G; het; QUAL=97;DP=10A->C; het; QUAL=98;DP=41----no rs idno
      chr1499991077Gintronic----G->A; hom; QUAL=118;DP=7G->A; hom; QUAL=10.4;DP=1----rs4905844no
      chr15102192540TexonicENST00000560013.1ENSG00000184277TM2D3--T->G; hom; QUAL=141;DP=8T->G; hom; QUAL=41;DP=3--nonsynonymous SNVnonsynonymous SNVrs675436no
      chr1540300214Gintronic----G->C; hom; QUAL=173;DP=17G->C; hom; QUAL=139;DP=9----rs2279580no
      chr1540855210TexonicENST00000558871.1ENSG00000128891C15orf57--T->A; het; QUAL=25;DP=14T->A; hom; QUAL=172;DP=19--nonsynonymous SNVnonsynonymous SNVrs10152546no
      chr1540898643GexonicENST00000527044.1ENSG00000137812CASC5--G->C; hom; QUAL=184;DP=29G->C; het; QUAL=31;DP=4--nonsynonymous SNVnonsynonymous SNVrs7177192no
      chr1541245329TUTR5----T->C; hom; QUAL=10.4;DP=1T->C; hom; QUAL=222;DP=14----rs11070311no
      chr1541247383Gintronic----G->A; hom; QUAL=97.5;DP=4G->A; hom; QUAL=160;DP=15----rs2412576no
      chr1541869545Tintronic----T->C; hom; QUAL=35.8;DP=2T->C; hom; QUAL=167;DP=8----rs1200342no
      chr1542118971AncRNA_UTR3----A->G; hom; QUAL=162;DP=12A->G; hom; QUAL=10.4;DP=1----rs3743024no
      chr1543212818CUTR5----C->G; hom; QUAL=102;DP=6C->G; hom; QUAL=38;DP=3----rs12437637no
      chr1544943757AexonicENST00000557866.1ENSG00000104133SPG11--A->G; het; QUAL=32;DP=4A->G; hom; QUAL=104;DP=5--nonsynonymous SNVnonsynonymous SNVrs3759871no
      chr1552202307GUTR3----G->A; het; QUAL=26;DP=4G->A; het; QUAL=61;DP=18----rs74408321no
      chr1556121886CUTR3----C->A; hom; QUAL=10.4;DP=1C->A; het; QUAL=103;DP=16----rs1042477no
      chr1559914314Tintergenic----T->C; het; QUAL=4.77;DP=1T->C; hom; QUAL=143;DP=8----rs7173057no
      chr1567483979GUTR3----G->A; hom; QUAL=41.8;DP=2G->A; hom; QUAL=222;DP=20----rs8031440no
      chr1569747829TexonicENST00000357790.5ENSG00000137818RPLP1--T->G; het; QUAL=9.52;DP=16T->G; het; QUAL=68;DP=46--nonsynonymous SNVnonsynonymous SNVno rs idno
      chr1585081832AncRNA_exonic----A->G; hom; QUAL=45.8;DP=2A->G; hom; QUAL=139;DP=8----rs150964no
      chr1589172352Cintronic----C->T; hom; QUAL=60;DP=3C->T; hom; QUAL=7.8;DP=1----rs3826040no
      chr1589744476GncRNA_exonic----G->T; hom; QUAL=60;DP=3G->T; hom; QUAL=134;DP=8----rs6416547no
      chr1591446316AUTR5----A->T; hom; QUAL=174;DP=9A->T; hom; QUAL=61.5;DP=4----rs28446644no
      chr1591448626CexonicENST00000559999.1ENSG00000196547MAN2A2--C->T; hom; QUAL=66;DP=3C->T; het; QUAL=69;DP=7--nonsynonymous SNVnonsynonymous SNVrs28446956no
      chr1593447747GUTR5----G->C; hom; QUAL=222;DP=17G->C; hom; QUAL=110;DP=6----rs111735136no
      chr1611154770GexonicENST00000409790.1ENSG00000038532CLEC16A--G->A; hom; QUAL=151;DP=9G->A; het; QUAL=92;DP=13--synonymous SNVsynonymous SNVrs2286973no
      chr161367030Tintronic----T->G; hom; QUAL=103;DP=7T->G; het; QUAL=4.77;DP=1----no rs idno
      chr1615202839GncRNA_exonic----G->T; hom; QUAL=140;DP=13G->C; hom; QUAL=68.5;DP=6----rs201218008no
      chr162011126Aintronic----A->G; hom; QUAL=153;DP=11A->G; hom; QUAL=74.5;DP=4----rs758335no
      chr162331430AexonicENST00000382381.3ENSG00000167972ABCA3--A->G; hom; QUAL=158;DP=16A->G; hom; QUAL=10.4;DP=1--synonymous SNVsynonymous SNVrs149532no
      chr162910767Aintergenic----A->G; hom; QUAL=121;DP=8A->G; hom; QUAL=94.3;DP=5----rs4785912no
      chr1629417386GncRNA_exonic----G->A; het; QUAL=151;DP=17G->A; het; QUAL=32;DP=6----no rs idno
      chr1629524549Tintergenic----T->C; hom; QUAL=54;DP=3T->C; hom; QUAL=9.31;DP=2----no rs idno
      chr162987279GexonicENST00000344592.5ENSG00000059122FLYWCH1--G->T; hom; QUAL=128;DP=8G->T; het; QUAL=44;DP=6--nonsynonymous SNVnonsynonymous SNVrs61747750no
      chr1629910518CUTR5----C->G; het; QUAL=4.77;DP=1C->G; hom; QUAL=27.8;DP=2----rs11344no
      chr1630936743Gintronic----G->A; hom; QUAL=163;DP=12G->A; hom; QUAL=195;DP=10----rs72799341no
      chr1631099859Gintronic----G->A; hom; QUAL=54;DP=3G->A; hom; QUAL=7.8;DP=1----rs73530203no
      chr1631133055Tintronic----T->A; hom; QUAL=132;DP=9T->A; hom; QUAL=10.4;DP=1----rs11639833no
      chr164517820Tintronic----T->C; het; QUAL=3.54;DP=4T->C; hom; QUAL=30.8;DP=2----no rs idno
      chr1657698501GUTR3----G->A; het; QUAL=126;DP=33G->A; het; QUAL=59;DP=29----rs1043540no
      chr1658577788TexonicENST00000569240.1ENSG00000125107CNOT1--T->C; het; QUAL=35;DP=21T->C; het; QUAL=78;DP=25--nonsynonymous SNVnonsynonymous SNVno rs idno
      chr1658591987Gintronic----G->A; hom; QUAL=55;DP=4G->A; hom; QUAL=45.8;DP=2----rs8047769no
      chr1658657340Aintronic----A->G; hom; QUAL=114;DP=6A->G; hom; QUAL=83.5;DP=5----rs181951no
      chr1669619388Tintronic----T->G; hom; QUAL=41.8;DP=2T->G; hom; QUAL=7.8;DP=1----rs168637no
      chr1669736628CUTR3----C->T; het; QUAL=131;DP=12C->T; hom; QUAL=10.4;DP=1----rs118037199no
      chr1670011414TncRNA_exonic----T->C; het; QUAL=53;DP=18T->C; het; QUAL=32;DP=20----no rs idno
      chr16769538GUTR3----G->A; het; QUAL=4.77;DP=1G->A; het; QUAL=4.77;DP=1----rs2003832no
      chr1683987606Gintronic----G->C; hom; QUAL=172;DP=15G->C; hom; QUAL=71.5;DP=4----rs2550437no
      chr1683990466Cintronic----C->G; hom; QUAL=161;DP=14C->G; hom; QUAL=7.8;DP=1----rs2665303no
      chr1684806837Aintronic----A->C; hom; QUAL=10.4;DP=1A->C; hom; QUAL=222;DP=36----rs3893782no
      chr1687388956Aintronic----A->C; hom; QUAL=222;DP=22A->C; hom; QUAL=104;DP=5----rs4240793no
      chr1687788864GexonicENST00000353170.5ENSG00000104731KLHDC4--G->A; hom; QUAL=154;DP=10G->A; hom; QUAL=163;DP=14--nonsynonymous SNVnonsynonymous SNVrs2303771no
      chr1687869313Tintronic----T->C; hom; QUAL=80.1;DP=7T->C; hom; QUAL=33;DP=3----rs55777228no
      chr1687879486Gintronic----G->A; hom; QUAL=90.5;DP=4G->A; hom; QUAL=35.8;DP=2----rs67288628no
      chr1687879522Gintronic----G->T; hom; QUAL=108;DP=4G->T; hom; QUAL=93.5;DP=4----rs997761no
      chr1687879562Cintronic----C->A; hom; QUAL=27.8;DP=2C->A; hom; QUAL=35.8;DP=2----rs997762no
      chr1687883721Aintronic----A->C; hom; QUAL=122;DP=6A->C; hom; QUAL=149;DP=11----rs6540092no
      chr1688880323CUTR3----C->G; het; QUAL=84;DP=6C->G; hom; QUAL=10.4;DP=1----rs3759946no
      chr168904214Tintronic----T->A; hom; QUAL=222;DP=24T->A; hom; QUAL=129;DP=7----rs386788721no
      chr168904215Aintronic----A->G; hom; QUAL=222;DP=24A->G; hom; QUAL=131;DP=7----rs4985040no
      chr1689474393GncRNA_intronic----G->A; hom; QUAL=222;DP=20G->A; het; QUAL=112;DP=15----rs747486no
      chr1689615838Aintronic----A->G; hom; QUAL=89.5;DP=4A->G; het; QUAL=4.77;DP=1----no rs idno
      chr1689755903Aintronic----A->G; hom; QUAL=71.5;DP=4A->G; hom; QUAL=68;DP=3----rs386569965no
      chr1690029417Gintronic----G->A; hom; QUAL=141;DP=11G->A; hom; QUAL=38.8;DP=2----rs4785751no
      chr171368511AUTR3----A->G; het; QUAL=89;DP=26A->G; het; QUAL=123;DP=18----no rs idno
      chr1715442693Aintronic----A->G; hom; QUAL=35.8;DP=2A->G; hom; QUAL=80.5;DP=4----rs2938157no
      chr1715464843Aintronic----A->G; hom; QUAL=134;DP=18A->G; hom; QUAL=116;DP=6----rs483702no
      chr1715616484Tintronic----T->C; hom; QUAL=154;DP=11T->C; hom; QUAL=106;DP=6----rs9910002no
      chr1716347325TexonicENST00000470794.1ENSG00000181350FAM211A--T->C; hom; QUAL=173;DP=8T->C; het; QUAL=95.1;DP=7--nonsynonymous SNVnonsynonymous SNVrs61745139no
      chr1717165418AexonicENST00000583160.1ENSG00000141030COPS3--A->C; het; QUAL=4.77;DP=1A->C; het; QUAL=54;DP=20--nonsynonymous SNVnonsynonymous SNVno rs idno
      chr1717733601Tintronic----T->C; het; QUAL=3.54;DP=3T->C; hom; QUAL=163;DP=14----no rs idno
      chr1717874486Cintronic----C->T; hom; QUAL=98.5;DP=4C->T; hom; QUAL=104;DP=5----rs8068175no
      chr1718167505TexonicENST00000395706.2ENSG00000177427MIEF2--T->C; hom; QUAL=94.3;DP=5T->C; het; QUAL=110;DP=10--synonymous SNVsynonymous SNVrs2605143no
      chr1718210810TUTR3----T->G; hom; QUAL=174;DP=19T->G; hom; QUAL=60;DP=3----rs4925166no
      chr1718965544CncRNA_exonic----C->T; het; QUAL=127;DP=13C->T; het; QUAL=110;DP=119----no rs idno
      chr172310130GncRNA_exonic----G->A; hom; QUAL=60;DP=3G->A; hom; QUAL=104;DP=5----rs3826335no
      chr1727065211TexonicENST00000543014.1ENSG00000160602NEK8--T->C; hom; QUAL=122;DP=12T->C; het; QUAL=188;DP=36--nonsynonymous SNVnonsynonymous SNVrs3809797no
      chr1727157362Tintronic----T->C; hom; QUAL=79.3;DP=5T->C; hom; QUAL=77.5;DP=4----rs12946132no
      chr1727493935GexonicENST00000527372.1ENSG00000196535MYO18A--G->A; het; QUAL=123;DP=12G->A; het; QUAL=225;DP=43--nonsynonymous SNVnonsynonymous SNVrs35771220no
      chr1728712047GexonicENST00000225719.4ENSG00000108582CPD--G->T; het; QUAL=119;DP=46G->T; het; QUAL=214;DP=21--nonsynonymous SNVnonsynonymous SNVno rs idno
      chr1729183492AncRNA_intronic----A->G; hom; QUAL=162;DP=11A->G; hom; QUAL=10.4;DP=1----no rs idno
      chr1729432775Tintronic----T->G; hom; QUAL=10.4;DP=1T->G; hom; QUAL=112;DP=6----rs2001287no
      chr1729512875Cintronic----C->A; hom; QUAL=166;DP=14C->A; hom; QUAL=10.4;DP=1----rs2952977no
      chr1733330150AUTR3----A->C; hom; QUAL=63;DP=3A->C; hom; QUAL=136;DP=8----rs4796030no
      chr1733464864CexonicENST00000442241.4ENSG00000073536NLE1--C->T; hom; QUAL=173;DP=15C->T; het; QUAL=26;DP=4--synonymous SNVsynonymous SNVrs7215209no
      chr173527281Cintronic----C->T; hom; QUAL=80.5;DP=4C->T; hom; QUAL=134;DP=10----rs222785no
      chr1735972254CncRNA_UTR3----C->T; hom; QUAL=80.5;DP=4C->T; hom; QUAL=102;DP=5----rs57962176no
      chr1736920438AUTR3----A->G; het; QUAL=88;DP=20A->G; hom; QUAL=28.8;DP=2----no rs idno
      chr1736940074Aintronic----A->G; hom; QUAL=181;DP=23A->G; hom; QUAL=92.3;DP=5----rs201710190no
      chr1738256693GUTR5----G->A; het; QUAL=104;DP=21G->A; het; QUAL=225;DP=27----rs939347no
      chr1740008056Cupstream----C->A; hom; QUAL=38.8;DP=2C->A; het; QUAL=66;DP=4----rs7216097no
      chr1741437552Tintergenic----T->C; hom; QUAL=6.17;DP=3T->C; hom; QUAL=82;DP=8----rs4792989no
      chr1741438562Tintergenic----T->C; hom; QUAL=127;DP=13T->C; het; QUAL=18.1;DP=50----rs72831089no
      chr1741623670CncRNA_UTR5----C->T; hom; QUAL=35.8;DP=2C->T; hom; QUAL=28.8;DP=2----rs3765174no
      chr1742110506Tintergenic----T->C; het; QUAL=26;DP=4T->C; hom; QUAL=7.8;DP=1----rs373720374no
      chr1745176547TncRNA_intronic----T->C; hom; QUAL=7.8;DP=1T->C; hom; QUAL=32.8;DP=2----no rs idno
      chr1745732605Gintronic----G->A; hom; QUAL=160;DP=17G->A; hom; QUAL=143;DP=10----rs11870935no
      chr174607889AncRNA_intronic----A->C; hom; QUAL=156;DP=10A->C; hom; QUAL=7.8;DP=1----rs3942769no
      chr1746126894Aintronic----A->G; hom; QUAL=134;DP=7A->G; hom; QUAL=161;DP=12----rs8080228no
      chr1746699669AUTR3----A->T; hom; QUAL=173;DP=18A->T; het; QUAL=137;DP=19----rs2303486no
      chr1746702643Gintronic----G->A; hom; QUAL=35.8;DP=2G->A; hom; QUAL=9.31;DP=3----rs2875820no
      chr1748713180AUTR3----A->G; het; QUAL=4.77;DP=1A->G; het; QUAL=19.1;DP=6----rs9303560no
      chr1748725515Gintronic----G->A; hom; QUAL=167;DP=12G->A; hom; QUAL=41.8;DP=2----rs373768373no
      chr1748726050Aintronic----A->G; hom; QUAL=132;DP=9A->G; hom; QUAL=132;DP=9----no rs idno
      chr1748748386Aintronic----A->G; hom; QUAL=178;DP=17A->G; hom; QUAL=6.02;DP=2----no rs idno
      chr175287946CUTR3----C->G; hom; QUAL=133;DP=9C->G; hom; QUAL=142;DP=8----rs11558no
      chr1756050724TUTR3----T->G; hom; QUAL=168;DP=14T->G; het; QUAL=90;DP=9----no rs idno
      chr1757917509TUTR3----T->A; het; QUAL=135;DP=64T->A; het; QUAL=225;DP=55----no rs idno
      chr1759431190Cintronic----C->G; hom; QUAL=35.8;DP=2C->G; hom; QUAL=116;DP=7----rs61515613no
      chr1759490235CUTR3----C->T; hom; QUAL=108;DP=7C->T; het; QUAL=4.77;DP=1----rs11871637no
      chr1759856810Gintronic----G->A; hom; QUAL=7.8;DP=1G->A; hom; QUAL=95.1;DP=6----rs7219791no
      chr1759856842Aintronic----A->G; hom; QUAL=7.8;DP=1A->G; hom; QUAL=108;DP=6----rs28571892no
      chr1762476429GexonicENST00000539111.2ENSG00000256525POLG2--G->A; hom; QUAL=7.8;DP=1G->A; hom; QUAL=161;DP=12--synonymous SNVsynonymous SNVrs147499130no
      chr1762526788Aintronic----A->G; het; QUAL=122;DP=31A->G; hom; QUAL=60;DP=3----no rs idno
      chr1765714359Gintronic----G->A; hom; QUAL=10.4;DP=1G->A; hom; QUAL=50;DP=3----rs3760226no
      chr1766510136Cintronic----C->T; hom; QUAL=41.8;DP=2C->T; hom; QUAL=10.4;DP=1----rs4561532no
      chr1770479684CncRNA_intronic----C->A; hom; QUAL=38.8;DP=2C->A; hom; QUAL=10.4;DP=1----rs2041631no
      chr1773625430GexonicENST00000423245.2ENSG00000108469RECQL5--G->A; hom; QUAL=154;DP=14G->A; hom; QUAL=131;DP=9--nonsynonymous SNVnonsynonymous SNVrs4788902down
      chr177393865Gintronic----G->A; hom; QUAL=60;DP=3G->A; hom; QUAL=77.5;DP=4----rs8080807no
      chr1774037715Aintronic----A->G; het; QUAL=4.77;DP=1A->G; hom; QUAL=161;DP=11----rs2598446no
      chr1774037772Tintronic----T->C; het; QUAL=4.77;DP=2T->C; hom; QUAL=145;DP=11----rs2598447no
      chr177407582Aintronic----A->G; hom; QUAL=28.8;DP=2A->G; hom; QUAL=32.8;DP=2----rs7215247no
      chr1777752395Gintronic----G->A; hom; QUAL=23.8;DP=2G->A; hom; QUAL=10.4;DP=1----rs111795035no
      chr1778966008Gintronic----G->C; hom; QUAL=131;DP=10G->C; hom; QUAL=10.4;DP=1----rs8080539no
      chr1779059230Cintronic----C->T; hom; QUAL=114;DP=8C->T; hom; QUAL=10.4;DP=1----rs8080815no
      chr1779508400TexonicENST00000537152.1ENSG00000185504C17orf70--T->C; hom; QUAL=71.5;DP=4T->C; het; QUAL=128;DP=19--nonsynonymous SNVnonsynonymous SNVrs386432317no
      chr1779880025CUTR3----C->G; het; QUAL=4.13;DP=22C->G; het; QUAL=83;DP=32----no rs idno
      chr1780164137Cintronic----C->T; hom; QUAL=60;DP=3C->T; hom; QUAL=35.8;DP=2----rs74523455no
      chr1780191817CUTR5----C->T; hom; QUAL=222;DP=12C->T; hom; QUAL=66;DP=3----rs10852794no
      chr178046772CexonicENST00000581082.1ENSG00000179094PER1--C->G; hom; QUAL=64.5;DP=4C->G; hom; QUAL=86.3;DP=5--nonsynonymous SNVnonsynonymous SNVrs2585405no
      chr17947840Aintronic----A->G; het; QUAL=4.77;DP=1A->G; hom; QUAL=10.4;DP=1----rs733789no
      chr17947856Aintronic----A->C; hom; QUAL=7.8;DP=1A->C; hom; QUAL=7.8;DP=1----rs733790no
      chr1821062427TUTR3----T->G; het; QUAL=14.2;DP=7T->G; het; QUAL=179;DP=12----no rs idno
      chr183264349Aintronic----A->G; hom; QUAL=41.8;DP=2A->G; hom; QUAL=10.4;DP=1----rs949303no
      chr1833779855CexonicENST00000261326.5ENSG00000075643MOCOS--C->T; hom; QUAL=152;DP=22C->T; hom; QUAL=145;DP=9--nonsynonymous SNVnonsynonymous SNVrs386602004down
      chr1834654895CUTR3----C->A; hom; QUAL=38.8;DP=2C->A; het; QUAL=80;DP=12----no rs idno
      chr1846916284Tintronic----T->G; hom; QUAL=77.5;DP=4T->G; hom; QUAL=68;DP=3----rs72642462no
      chr1847561225Gintronic----G->C; hom; QUAL=20.8;DP=2G->C; hom; QUAL=140;DP=8----rs7234190no
      chr1847810351AexonicENST00000412036.2ENSG00000154832CXXC1--A->G; hom; QUAL=35.8;DP=2A->G; hom; QUAL=170;DP=8--nonsynonymous SNVnonsynonymous SNVrs7228084no
      chr1910679240CexonicENST00000393599.2ENSG00000129355CDKN2D--C->G; hom; QUAL=95.5;DP=4C->G; hom; QUAL=32.8;DP=2--nonsynonymous SNVnonsynonymous SNVrs1968445no
      chr1910689955Gintronic----G->A; hom; QUAL=222;DP=12G->A; hom; QUAL=10.4;DP=1----rs12460574no
      chr1913010643GUTR3----G->T; hom; QUAL=176;DP=17G->T; hom; QUAL=77.5;DP=8----rs9384no
      chr1913263055CUTR5----C->G; hom; QUAL=65.5;DP=4C->G; het; QUAL=37;DP=18----rs55724477no
      chr1913949281Cintergenic----C->T; hom; QUAL=10.4;DP=1C->T; hom; QUAL=7.8;DP=1----no rs idno
      chr1914594025Cintronic----C->T; hom; QUAL=63;DP=3C->T; hom; QUAL=106;DP=5----rs12974884no
      chr1914594075Tintronic----T->C; hom; QUAL=57;DP=3T->C; hom; QUAL=215;DP=10----rs12982274no
      chr1914594138Tintronic----T->C; het; QUAL=57;DP=5T->C; hom; QUAL=104;DP=5----rs12982526no
      chr1914602107Gintronic----G->T; hom; QUAL=125;DP=6G->T; hom; QUAL=187;DP=10----rs7258106no
      chr1915513054Gintronic----G->A; hom; QUAL=68;DP=3G->A; hom; QUAL=7.8;DP=1----rs12972998no
      chr1917452993AUTR3----A->G; hom; QUAL=7.8;DP=1A->G; hom; QUAL=7.8;DP=1----rs113487706no
      chr1917453014GUTR3----G->A; hom; QUAL=7.8;DP=1G->A; hom; QUAL=7.8;DP=1----rs7508138no
      chr1917619429AncRNA_intronic----A->G; hom; QUAL=13.9;DP=2A->G; het; QUAL=4.77;DP=1----rs1896782no
      chr191842884Gintronic----G->A; hom; QUAL=74.5;DP=4G->A; het; QUAL=47;DP=10----rs12462721no
      chr191842919Aintronic----A->G; hom; QUAL=68.5;DP=4A->G; het; QUAL=97;DP=8----rs12460791no
      chr1918671740CncRNA_intronic----C->T; hom; QUAL=7.8;DP=1C->T; hom; QUAL=7.8;DP=1----rs59798925no
      chr1923537146Aintronic----A->T; hom; QUAL=151;DP=12A->T; hom; QUAL=7.8;DP=1----rs8109526no
      chr1930200276Tintronic----T->C; hom; QUAL=155;DP=10T->C; hom; QUAL=28.8;DP=2----rs2866311no
      chr1933125055Aintronic----A->G; hom; QUAL=148;DP=12A->G; hom; QUAL=107;DP=5----rs17693106no
      chr1934287386CUTR5----C->T; hom; QUAL=7.8;DP=1C->T; hom; QUAL=20.8;DP=2----rs28524164no
      chr1934304903CUTR3----C->G; hom; QUAL=129;DP=9C->G; het; QUAL=225;DP=40----rs14810no
      chr1935507016CncRNA_intronic----C->T; hom; QUAL=11.8;DP=4C->T; hom; QUAL=189;DP=8----rs59900101no
      chr1935507073AncRNA_intronic----A->G; hom; QUAL=87.5;DP=4A->G; hom; QUAL=87.5;DP=4----rs59344976no
      chr1936261208AncRNA_intronic----A->G; hom; QUAL=154;DP=16A->G; hom; QUAL=152;DP=10----no rs idno
      chr1936595436AexonicENST00000401500.2ENSG00000075702WDR62--A->C; hom; QUAL=222;DP=27A->C; hom; QUAL=222;DP=19--nonsynonymous SNVnonsynonymous SNVrs1008328down
      chr193752563GexonicENST00000316757.3ENSG00000011132APBA3--G->A; hom; QUAL=142;DP=12G->A; hom; QUAL=66;DP=3--synonymous SNVsynonymous SNVrs80066100no
      chr1938771083Tintronic----T->C; hom; QUAL=158;DP=19T->C; hom; QUAL=175;DP=18----rs58633465no
      chr1939955673AexonicENST00000402194.2ENSG00000196235SUPT5H--A->C; het; QUAL=88;DP=6A->C; het; QUAL=3.54;DP=30--nonsynonymous SNVnonsynonymous SNVno rs idno
      chr1940481883Cintronic----C->T; hom; QUAL=222;DP=32C->T; hom; QUAL=7.8;DP=1----rs62108923no
      chr194050278Tintronic----T->C; hom; QUAL=35.8;DP=2T->C; hom; QUAL=63;DP=3----rs4807539no
      chr1940711333Aintronic----A->G; hom; QUAL=7.8;DP=1A->G; hom; QUAL=11.3;DP=3----rs892117no
      chr1940789926Cintronic----C->T; hom; QUAL=131;DP=7C->T; hom; QUAL=38.8;DP=2----rs12459567no
      chr194107668Gintronic----G->A; hom; QUAL=151;DP=16G->A; hom; QUAL=222;DP=18----rs11671735no
      chr1941125770Cintronic----C->T; hom; QUAL=80.5;DP=4C->T; hom; QUAL=222;DP=12----rs2604908no
      chr1941129842CexonicENST00000601032.1ENSG00000090006LTBP4--C->T; het; QUAL=70;DP=5C->T; het; QUAL=6.2;DP=13--stopgain SNVstopgain SNVrs7367no
      chr1941681915Gintergenic----G->A; hom; QUAL=222;DP=20G->A; hom; QUAL=156;DP=11----rs1616286no
      chr1942369743Tintronic----T->C; het; QUAL=48;DP=17T->C; het; QUAL=159;DP=13----rs7259596no
      chr1942703833AexonicENST00000336034.4ENSG00000160570DEDD2--A->G; hom; QUAL=109;DP=8A->G; het; QUAL=29;DP=3--nonsynonymous SNVnonsynonymous SNVrs2303652no
      chr1943013363AexonicENST00000161559.6ENSG00000079385CEACAM1--A->G; hom; QUAL=41.8;DP=2A->G; hom; QUAL=104;DP=5--nonsynonymous SNVnonsynonymous SNVrs11666350no
      chr1944008355CUTR5----C->A; hom; QUAL=90.1;DP=7C->A; het; QUAL=155;DP=20----rs2599448no
      chr1944246970Cintronic----C->T; hom; QUAL=222;DP=25C->T; hom; QUAL=32.8;DP=2----rs7256472no
      chr1945874412Aupstream----A->C; hom; QUAL=28.8;DP=2A->C; hom; QUAL=72;DP=3----rs3916788no
      chr1945921149Tintronic----T->C; hom; QUAL=10.4;DP=1T->C; hom; QUAL=154;DP=10----no rs idno
      chr1946286714AUTR3----A->C; hom; QUAL=143;DP=13A->C; hom; QUAL=10.4;DP=1----rs2070736no
      chr1946499537AUTR5----A->G; hom; QUAL=155;DP=10A->G; hom; QUAL=106;DP=5----rs8111976no
      chr1946695739TncRNA_intronic----T->C; hom; QUAL=105;DP=10T->C; het; QUAL=18.1;DP=4----no rs idno
      chr1946868960Aintronic----A->G; hom; QUAL=32.8;DP=2A->G; hom; QUAL=60.3;DP=5----rs8105297no
      chr1947283835Tintronic----T->C; het; QUAL=31;DP=16T->C; het; QUAL=73;DP=36----no rs idno
      chr1947507468GUTR3----G->A; hom; QUAL=60;DP=3G->A; het; QUAL=4.77;DP=1----rs1052668no
      chr1948592109Tintronic----T->C; hom; QUAL=222;DP=32T->C; hom; QUAL=133;DP=7----rs441644no
      chr1949377086TexonicENST00000200453.5ENSG00000087074PPP1R15A--T->C; het; QUAL=225;DP=134T->C; het; QUAL=225;DP=76--nonsynonymous SNVnonsynonymous SNVrs611251down
      chr1949426954Adownstream----A->G; hom; QUAL=80.5;DP=4A->G; hom; QUAL=166;DP=12----no rs idno
      chr1950099901CexonicENST00000418929.2ENSG00000126464PRR12--C->T; hom; QUAL=99.1;DP=6C->T; hom; QUAL=56.5;DP=4--nonsynonymous SNVnonsynonymous SNVno rs idno
      chr1950168871GUTR5----G->A; hom; QUAL=174;DP=17G->A; het; QUAL=88;DP=9----rs386564449no
      chr1950410363CUTR3----C->T; het; QUAL=77;DP=6C->T; het; QUAL=86;DP=24----rs11083988no
      chr1952299675Gintronic----G->A; hom; QUAL=45.8;DP=2G->A; hom; QUAL=222;DP=20----rs4802866no
      chr1953307658Cintronic----C->A; hom; QUAL=148;DP=12C->A; hom; QUAL=147;DP=11----rs7255800no
      chr1953453777CexonicENST00000357666.4ENSG00000180257ZNF816--C->T; hom; QUAL=140;DP=10C->T; hom; QUAL=222;DP=30--synonymous SNVsynonymous SNVrs8110062no
      chr1953936777TncRNA_intronic----T->C; hom; QUAL=165;DP=12T->C; hom; QUAL=94.3;DP=5----rs11084245no
      chr1953943838CncRNA_intronic----C->T; hom; QUAL=173;DP=18C->T; hom; QUAL=165;DP=12----rs7246687no
      chr1954495049Aupstream----A->G; hom; QUAL=127;DP=7A->G; het; QUAL=117;DP=16----rs3810245no
      chr1954495932AUTR5----A->G; hom; QUAL=222;DP=39A->G; hom; QUAL=222;DP=21----rs3810244no
      chr1957802806CexonicENST00000537645.1ENSG00000197714ZNF460--C->T; het; QUAL=162;DP=18C->T; het; QUAL=68;DP=60--synonymous SNVsynonymous SNVrs2041109no
      chr1957809978Aintergenic----A->G; het; QUAL=27;DP=20A->G; het; QUAL=119;DP=24----no rs idno
      chr1957812712Cintergenic----C->T; het; QUAL=128;DP=34C->T; het; QUAL=78;DP=50----rs2361124no
      chr1957812726Aintergenic----A->T; het; QUAL=110;DP=35A->T; het; QUAL=82;DP=49----rs2361123no
      chr1958385762CexonicENST00000435989.2ENSG00000204514ZNF814--C->G; hom; QUAL=7.8;DP=1C->G; hom; QUAL=65.1;DP=8--synonymous SNVsynonymous SNVrs199732634no
      chr1958424907Aintronic----A->G; hom; QUAL=147;DP=11A->G; hom; QUAL=7.8;DP=1----rs10412003no
      chr1959093999AncRNA_exonic----A->G; het; QUAL=58;DP=22A->G; het; QUAL=84;DP=12----no rs idno
      chr19649110Gintronic----G->C; hom; QUAL=137;DP=9G->C; hom; QUAL=63.5;DP=4----rs2040736no
      chr198921033CUTR3----C->T; hom; QUAL=152;DP=11C->T; hom; QUAL=53;DP=3----rs250316no
      chr2100027789Cintronic----C->T; hom; QUAL=161;DP=18C->T; hom; QUAL=80.5;DP=4----rs13420293no
      chr210053858Gintronic----G->A; hom; QUAL=147;DP=12G->A; hom; QUAL=115;DP=9----no rs idno
      chr2101638888AexonicENST00000409318.1ENSG00000204634TBC1D8--A->G; hom; QUAL=60;DP=3A->G; het; QUAL=5.46;DP=12--synonymous SNVsynonymous SNVrs386585127no
      chr210193069AUTR3----A->T; hom; QUAL=10.4;DP=1A->T; het; QUAL=76;DP=16----rs72786612no
      chr210722877Cintronic----C->T; hom; QUAL=182;DP=24C->T; hom; QUAL=173;DP=15----rs10803723no
      chr2109513601AexonicENST00000409271.1ENSG00000135960EDAR--A->G; het; QUAL=181;DP=28A->G; het; QUAL=225;DP=92--nonsynonymous SNVnonsynonymous SNVrs3827760down
      chr2109547048Tintronic----T->C; hom; QUAL=77.5;DP=4T->C; het; QUAL=225;DP=24----rs899259no
      chr2109601804Cintronic----C->T; hom; QUAL=142;DP=8C->T; hom; QUAL=41.8;DP=2----rs260678no
      chr2112228828TncRNA_intronic----T->C; hom; QUAL=7.8;DP=1T->C; hom; QUAL=85.5;DP=4----rs140064193no
      chr2112813163GUTR5----G->A; hom; QUAL=113;DP=6G->A; het; QUAL=104;DP=15----rs10176769no
      chr2130807780GncRNA_exonic----G->C; hom; QUAL=44;DP=10G->C; hom; QUAL=33.1;DP=6----rs55647081no
      chr2130813458Tintergenic----T->C; hom; QUAL=183;DP=25T->C; hom; QUAL=192;DP=11----rs4536603no
      chr2130817693Tintergenic----T->C; hom; QUAL=10.4;DP=1T->C; hom; QUAL=50;DP=3----no rs idno
      chr2130821470Gintergenic----G->A; hom; QUAL=7.8;DP=1G->A; hom; QUAL=10.4;DP=1----rs61277558no
      chr2132044753AexonicENST00000416266.1ENSG00000178206CYP4F31P--A->C; hom; QUAL=36.5;DP=4A->C; hom; QUAL=12;DP=2--synonymous SNVsynonymous SNVno rs idno
      chr2160076309AexonicENST00000454300.1ENSG00000115183TANC1--A->G; hom; QUAL=163;DP=17A->G; het; QUAL=71;DP=6--synonymous SNVsynonymous SNVrs11903200no
      chr2170427350Tintronic----T->C; hom; QUAL=156;DP=15T->C; hom; QUAL=35.8;DP=2----no rs idno
      chr2170427467Tintronic----T->C; hom; QUAL=157;DP=15T->C; hom; QUAL=27.8;DP=2----no rs idno
      chr2178119204Aintronic----A->C; hom; QUAL=10.4;DP=1A->C; hom; QUAL=28.8;DP=2----rs386503713no
      chr2178127089Aintronic----A->G; hom; QUAL=120;DP=6A->G; hom; QUAL=30.8;DP=4----rs34009885no
      chr2191799592AUTR3----A->G; hom; QUAL=85.5;DP=4A->G; het; QUAL=158;DP=20----rs1045208no
      chr2192170389Aintronic----A->G; hom; QUAL=23;DP=3A->G; hom; QUAL=146;DP=6----rs1973069no
      chr2201683695Tintronic----T->C; hom; QUAL=171;DP=15T->C; hom; QUAL=119;DP=6----rs2881880no
      chr2204087037Aintronic----A->G; hom; QUAL=172;DP=16A->G; hom; QUAL=30.8;DP=2----rs10178417no
      chr2211030469Gintronic----G->A; hom; QUAL=45.8;DP=2G->A; hom; QUAL=102;DP=5----rs263692no
      chr2217364452Cintronic----C->G; het; QUAL=225;DP=26C->G; het; QUAL=214;DP=19----rs284573no
      chr2219264107Gintronic----G->A; hom; QUAL=103;DP=4G->A; hom; QUAL=118;DP=7----rs2739049no
      chr2219523433TUTR5----T->G; hom; QUAL=7.8;DP=1T->G; hom; QUAL=35.8;DP=2----rs4674324no
      chr2220249908Tintronic----T->C; hom; QUAL=123;DP=7T->C; hom; QUAL=119;DP=6----rs1877868no
      chr2220367923TncRNA_intronic----T->C; hom; QUAL=41.8;DP=2T->C; hom; QUAL=41.8;DP=2----rs4672930no
      chr2233245141TexonicENST00000392027.2ENSG00000163283ALPP--T->C; het; QUAL=5.46;DP=12T->C; het; QUAL=158;DP=29--synonymous SNVsynonymous SNVrs2260309down
      chr2234753008Gintronic----G->A; hom; QUAL=60;DP=3G->A; hom; QUAL=35.8;DP=2----rs169925no
      chr2236403607Cintronic----C->A; hom; QUAL=7.8;DP=1C->A; hom; QUAL=23.8;DP=2----rs3738998no
      chr2241373531Tintergenic----T->C; hom; QUAL=57.1;DP=6T->C; hom; QUAL=100;DP=5----rs371136599no
      chr2241558936Cintronic----C->T; hom; QUAL=152;DP=34C->T; hom; QUAL=40.5;DP=5----rs10933621no
      chr2241562379Cintronic----C->T; hom; QUAL=96.3;DP=5C->T; het; QUAL=131;DP=19----rs11886370no
      chr2242189829Cintronic----C->T; het; QUAL=111;DP=27C->T; hom; QUAL=85.5;DP=4----rs61332497no
      chr2242576357TexonicENST00000407315.1ENSG00000176946THAP4--T->G; het; QUAL=4.77;DP=1T->G; het; QUAL=41;DP=19--nonsynonymous SNVnonsynonymous SNVno rs idno
      chr2242594510Tintronic----T->C; hom; QUAL=150;DP=16T->C; hom; QUAL=35.8;DP=2----rs146085946no
      chr2242611374Aintronic----A->G; hom; QUAL=85.5;DP=4A->G; hom; QUAL=28.8;DP=2----rs148264135no
      chr226259885Aintronic----A->G; hom; QUAL=7.8;DP=1A->G; hom; QUAL=50;DP=3----rs6709595no
      chr233809471CUTR3----C->G; hom; QUAL=7.8;DP=1C->G; hom; QUAL=68;DP=3----rs7596614no
      chr238561431Tintronic----T->C; hom; QUAL=117;DP=6T->C; hom; QUAL=133;DP=7----no rs idno
      chr239246683Cintronic----C->T; hom; QUAL=158;DP=13C->T; hom; QUAL=84.3;DP=5----rs2888585no
      chr239316301Tintronic----T->C; hom; QUAL=66;DP=3T->C; hom; QUAL=7.8;DP=1----rs378698no
      chr239324295Tintronic----T->C; hom; QUAL=38.8;DP=2T->C; hom; QUAL=68;DP=3----no rs idno
      chr239326835Cintronic----C->G; hom; QUAL=7.8;DP=1C->G; hom; QUAL=35.8;DP=2----rs297153no
      chr239512437Tintronic----T->C; hom; QUAL=153;DP=6T->C; hom; QUAL=136;DP=8----rs12151392no
      chr239524739Cintronic----C->T; hom; QUAL=106;DP=5C->T; hom; QUAL=7.8;DP=1----rs12622941no
      chr244446931Tintronic----T->A; hom; QUAL=165;DP=14T->A; hom; QUAL=45.8;DP=2----rs5024499no
      chr244540241Cintronic----C->T; hom; QUAL=45.8;DP=2C->T; hom; QUAL=149;DP=9----rs1372080no
      chr247398394Gintronic----G->A; hom; QUAL=125;DP=7G->A; hom; QUAL=176;DP=9----rs815816no
      chr266619220CncRNA_exonic----C->T; hom; QUAL=48.8;DP=2C->T; het; QUAL=105;DP=16----no rs idno
      chr269550652GUTR3----G->A; hom; QUAL=146;DP=9G->A; het; QUAL=225;DP=39----rs10185336no
      chr270068652Gintronic----G->T; hom; QUAL=35.8;DP=2G->T; hom; QUAL=64.5;DP=4----no rs idno
      chr275101454TexonicENST00000290573.2ENSG00000159399HK2--T->C; hom; QUAL=7.8;DP=1T->C; het; QUAL=85;DP=5--synonymous SNVsynonymous SNVrs2229622down
      chr296605951Tintronic----T->C; hom; QUAL=81.5;DP=4T->C; hom; QUAL=167;DP=8----no rs idno
      chr296627032Tintronic----T->G; hom; QUAL=113;DP=15T->G; hom; QUAL=198;DP=13----rs4530407no
      chr299811590TexonicENST00000410042.1ENSG00000273155MRPL30--T->G; het; QUAL=95;DP=15T->G; het; QUAL=85;DP=25--synonymous SNVsynonymous SNVno rs idno
      chr2021295509Gintronic----G->T; hom; QUAL=50;DP=3G->T; hom; QUAL=222;DP=16----rs4813425no
      chr2021308812Gintronic----G->A; hom; QUAL=41.8;DP=2G->A; hom; QUAL=45.8;DP=2----rs6047380no
      chr202445533Aintronic----A->C; hom; QUAL=10.4;DP=1A->C; hom; QUAL=7.8;DP=1----rs75586636no
      chr2025670729Tintronic----T->C; het; QUAL=133;DP=44T->C; hom; QUAL=146;DP=9----no rs idno
      chr2030137432Aintronic----A->G; hom; QUAL=38.8;DP=2A->G; hom; QUAL=222;DP=18----rs6059929no
      chr2030137474Cintronic----C->T; hom; QUAL=41.8;DP=2C->T; hom; QUAL=222;DP=14----rs6059930no
      chr2030261562Gintronic----G->C; hom; QUAL=92.5;DP=4G->C; hom; QUAL=38.8;DP=2----rs6060621no
      chr2030266845Aintronic----A->G; het; QUAL=32;DP=4A->G; hom; QUAL=144;DP=11----rs6060652no
      chr2030287328TncRNA_intronic----T->G; hom; QUAL=212;DP=10T->G; hom; QUAL=87.5;DP=4----rs1994251no
      chr203191915Aintronic----A->G; hom; QUAL=173;DP=16A->G; hom; QUAL=222;DP=16----no rs idno
      chr2032101266Aintronic----A->G; hom; QUAL=109;DP=4A->G; hom; QUAL=38.8;DP=2----no rs idno
      chr2032259315Gintronic----G->A; het; QUAL=125;DP=13G->A; hom; QUAL=7.8;DP=1----no rs idno
      chr2033402047Tintronic----T->C; hom; QUAL=79.3;DP=5T->C; hom; QUAL=94.3;DP=5----no rs idno
      chr2034377460Cintronic----C->T; hom; QUAL=7.8;DP=1C->T; hom; QUAL=97.3;DP=5----rs6142445no
      chr2034696092Aintronic----A->G; hom; QUAL=110;DP=6A->G; hom; QUAL=57;DP=3----no rs idno
      chr203828856Cintronic----C->A; hom; QUAL=180;DP=28C->A; hom; QUAL=94.3;DP=5----rs6084495no
      chr203849859Adownstream----A->G; hom; QUAL=28.8;DP=3A->G; het; QUAL=106;DP=22----no rs idno
      chr20389984Cintronic----C->T; hom; QUAL=137;DP=12C->T; hom; QUAL=35.8;DP=2----rs4815586no
      chr20390702Gintronic----G->C; hom; QUAL=60;DP=3G->C; hom; QUAL=41.8;DP=2----rs145976650no
      chr20390801Cintronic----C->T; hom; QUAL=48.8;DP=2C->T; hom; QUAL=222;DP=16----rs149689056no
      chr20390858Tintronic----T->C; hom; QUAL=42.8;DP=2T->C; het; QUAL=121;DP=9----rs145482638no
      chr20396689Gintronic----G->A; hom; QUAL=63;DP=3G->A; het; QUAL=81;DP=8----rs140285933no
      chr20402710Aintronic----A->G; hom; QUAL=137;DP=10A->G; hom; QUAL=27.8;DP=12----rs2057251no
      chr20416149AUTR3----A->G; hom; QUAL=63;DP=3A->G; hom; QUAL=188;DP=10----rs6695no
      chr2043517041Cintronic----C->T; hom; QUAL=176;DP=20C->T; het; QUAL=37;DP=7----rs2284265no
      chr2043522725Aintronic----A->G; hom; QUAL=175;DP=16A->G; hom; QUAL=7.8;DP=1----rs16989474no
      chr2043522834Cintronic----C->T; hom; QUAL=176;DP=16C->T; hom; QUAL=7.8;DP=1----rs6031855no
      chr20443132AUTR5----A->G; hom; QUAL=150;DP=16A->G; het; QUAL=118;DP=16----no rs idno
      chr2046215767Cintronic----C->T; hom; QUAL=148;DP=9C->T; het; QUAL=19.1;DP=20----rs72645213no
      chr2047690490Aintronic----A->G; hom; QUAL=10.4;DP=1A->G; hom; QUAL=108;DP=6----no rs idno
      chr2047793587Tintronic----T->C; hom; QUAL=149;DP=9T->C; hom; QUAL=63;DP=3----no rs idno
      chr2048720687Tintronic----T->C; hom; QUAL=42.8;DP=2T->C; hom; QUAL=85.5;DP=4----rs6020266no
      chr2052187612GncRNA_intronic----G->C; hom; QUAL=142;DP=10G->C; hom; QUAL=83.5;DP=4----rs8184575no
      chr205552847Gintronic----G->C; hom; QUAL=10.4;DP=1G->C; hom; QUAL=119;DP=6----rs6085211no
      chr205566109Cintronic----C->T; hom; QUAL=174;DP=16C->T; hom; QUAL=93.3;DP=22----rs6053519no
      chr205569822Gintronic----G->C; hom; QUAL=10.4;DP=1G->C; hom; QUAL=60;DP=3----rs6038214no
      chr2057253296AUTR3----A->G; hom; QUAL=142;DP=8A->G; hom; QUAL=60;DP=3----rs4812024no
      chr206056356GUTR3----G->A; hom; QUAL=56;DP=3G->A; het; QUAL=115;DP=10----rs1059391no
      chr2060634716Cintronic----C->A; hom; QUAL=178;DP=21C->A; hom; QUAL=7.8;DP=1----rs6061411no
      chr2060825595Cintronic----C->T; hom; QUAL=71.5;DP=23C->T; hom; QUAL=117;DP=6----rs6062168no
      chr2060835649Cintronic----C->G; hom; QUAL=42.8;DP=2C->G; hom; QUAL=57;DP=3----rs4925363no
      chr2060858758Cintronic----C->T; hom; QUAL=145;DP=9C->T; hom; QUAL=160;DP=16----rs35636653no
      chr2127423131Cintronic----C->T; hom; QUAL=109;DP=4C->T; hom; QUAL=222;DP=17----rs2830026no
      chr2127496900Tintronic----T->C; hom; QUAL=164;DP=24T->C; hom; QUAL=134;DP=9----rs9305280no
      chr2127541944AncRNA_intronic----A->G; hom; QUAL=95.5;DP=4A->G; hom; QUAL=165;DP=14----rs469420no
      chr2130375018Gintergenic----G->A; het; QUAL=93;DP=19G->A; hom; QUAL=35.8;DP=2----rs73190194no
      chr2134125155Aintronic----A->G; hom; QUAL=7.8;DP=1A->G; hom; QUAL=95.5;DP=4----rs13052412no
      chr2138086271Gintronic----G->A; hom; QUAL=143;DP=8G->A; hom; QUAL=117;DP=6----rs2243490no
      chr2138092039Aintronic----A->C; hom; QUAL=209;DP=10A->C; hom; QUAL=222;DP=22----rs2070650no
      chr2138336120Cintronic----C->T; hom; QUAL=222;DP=20C->T; hom; QUAL=7.8;DP=1----rs11701986no
      chr2138503762Tintronic----T->G; hom; QUAL=106;DP=6T->G; hom; QUAL=100;DP=5----rs4261789no
      chr2142582424Tintronic----T->C; hom; QUAL=38.8;DP=2T->C; hom; QUAL=7.8;DP=1----rs914180no
      chr2144324365GexonicENST00000354250.2ENSG00000160194NDUFV3--G->A; hom; QUAL=7.8;DP=1G->A; hom; QUAL=7.8;DP=1--nonsynonymous SNVnonsynonymous SNVrs386501252no
      chr2145131795Cintergenic----C->T; hom; QUAL=7.8;DP=1C->T; hom; QUAL=7.8;DP=1----rs2329594no
      chr2145211607Aintronic----A->G; hom; QUAL=159;DP=18A->G; hom; QUAL=149;DP=10----rs1964982no
      chr2145661290Tupstream----T->C; hom; QUAL=94.5;DP=4T->C; het; QUAL=29;DP=4----no rs idno
      chr2146942371Aintronic----A->G; hom; QUAL=41.8;DP=2A->G; hom; QUAL=7.8;DP=1----rs9982301no
      chr2147661235CncRNA_exonic----C->T; hom; QUAL=38.8;DP=2C->T; hom; QUAL=139;DP=13----rs3788252no
      chr2147696582Tintronic----T->C; hom; QUAL=135;DP=8T->C; hom; QUAL=35.8;DP=2----no rs idno
      chr219911785CncRNA_intronic----C->T; hom; QUAL=163;DP=18C->T; hom; QUAL=128;DP=8----rs368264694no
      chr219911815TncRNA_intronic----T->C; hom; QUAL=158;DP=18T->C; hom; QUAL=127;DP=8----rs371290492no
      chr219955322CncRNA_intronic----C->T; hom; QUAL=60;DP=3C->T; hom; QUAL=32.8;DP=2----no rs idno
      chr219957676AncRNA_intronic----A->C; hom; QUAL=35.8;DP=2A->C; hom; QUAL=222;DP=14----no rs idno
      chr219962753TncRNA_intronic----T->A; hom; QUAL=138;DP=10T->A; hom; QUAL=122;DP=8----rs371948973no
      chr2221291329Cintronic----C->A; hom; QUAL=38.8;DP=2C->A; hom; QUAL=120;DP=6----rs7287892no
      chr2221838339CncRNA_exonic----C->T; hom; QUAL=94.1;DP=7C->T; hom; QUAL=121;DP=7----rs201760046no
      chr2231667125TexonicENST00000444929.2ENSG00000182541LIMK2--T->G; het; QUAL=15.1;DP=46T->G; het; QUAL=31;DP=44--nonsynonymous SNVnonsynonymous SNVno rs idno
      chr2232081254AUTR3----A->C; hom; QUAL=150;DP=9A->C; hom; QUAL=161;DP=11----no rs idno
      chr2238612031AUTR3----A->C; het; QUAL=133;DP=20A->C; hom; QUAL=41.8;DP=4----no rs idno
      chr2239414772AUTR3----A->G; het; QUAL=9.52;DP=11A->G; het; QUAL=73;DP=5----no rs idno
      chr2239644273Gintergenic----G->A; hom; QUAL=10.4;DP=1G->A; hom; QUAL=106;DP=5----rs130651no
      chr2240723709AUTR3----A->G; hom; QUAL=42.8;DP=2A->G; hom; QUAL=10.4;DP=1----rs139918no
      chr2240984968Tintronic----T->C; hom; QUAL=167;DP=8T->C; hom; QUAL=114;DP=6----no rs idno
      chr2241517903Aintronic----A->G; hom; QUAL=45.8;DP=2A->G; hom; QUAL=7.8;DP=1----rs1983674no
      chr2245123841Cintronic----C->G; hom; QUAL=35.8;DP=2C->G; hom; QUAL=7.8;DP=1----rs5765943no
      chr2245250631Aintronic----A->G; het; QUAL=57;DP=5A->G; hom; QUAL=35.8;DP=2----no rs idno
      chr2246496760Aintronic----A->G; hom; QUAL=35.8;DP=2A->G; het; QUAL=4.77;DP=1----rs6009080no
      chr2248033371GncRNA_intronic----G->A; hom; QUAL=45.8;DP=2G->A; hom; QUAL=95.3;DP=5----rs738717no
      chr2248130194TncRNA_intronic----T->C; hom; QUAL=32.8;DP=2T->C; hom; QUAL=79.5;DP=4----rs132192no
      chr2248140748GncRNA_intronic----G->C; hom; QUAL=38.8;DP=2G->C; hom; QUAL=7.8;DP=1----rs4823687no
      chr2248200143GncRNA_intronic----G->A; hom; QUAL=45.8;DP=2G->A; hom; QUAL=138;DP=11----no rs idno
      chr3100292452Gintronic----G->C; hom; QUAL=63;DP=3G->A; hom; QUAL=38.8;DP=2----no rs idno
      chr3105471508Gintronic----G->T; hom; QUAL=153;DP=13G->T; hom; QUAL=40;DP=3----rs4894947no
      chr3105559381Tintronic----T->C; hom; QUAL=150;DP=9T->C; hom; QUAL=10.4;DP=1----rs11924926no
      chr3111440689Cintronic----C->T; hom; QUAL=41.8;DP=2C->T; hom; QUAL=60;DP=3----rs9877859no
      chr3122442813Tintronic----T->C; hom; QUAL=30.8;DP=2T->C; het; QUAL=4.77;DP=1----rs80268099no
      chr3123634046GexonicENST00000419247.1ENSG00000175455CCDC14--G->A; hom; QUAL=132;DP=8G->A; hom; QUAL=57;DP=3--stoploss SNVstoploss SNVrs2700373no
      chr3126180820GexonicENST00000336332.5ENSG00000070476ZXDC--G->A; het; QUAL=133;DP=35G->A; het; QUAL=98;DP=12--nonsynonymous SNVnonsynonymous SNVrs16837497no
      chr3126194357GexonicENST00000336332.5ENSG00000070476ZXDC--G->C; hom; QUAL=222;DP=15G->C; hom; QUAL=7.8;DP=1--nonsynonymous SNVnonsynonymous SNVrs7624748no
      chr3129539734Aintronic----A->G; hom; QUAL=119;DP=6A->G; het; QUAL=4.77;DP=1----rs2717248no
      chr3136574501AexonicENST00000446465.2ENSG00000168917SLC35G2--A->G; hom; QUAL=89.5;DP=4A->G; hom; QUAL=68;DP=3--nonsynonymous SNVnonsynonymous SNVrs1052618down
      chr3149095470GUTR5----G->A; hom; QUAL=156;DP=10G->A; het; QUAL=59;DP=4----rs73152606no
      chr3149236566CUTR3----C->T; hom; QUAL=222;DP=29C->T; hom; QUAL=90.5;DP=4----rs191861175no
      chr3150259942TUTR3----T->C; hom; QUAL=7.8;DP=1T->C; hom; QUAL=117;DP=6----rs8052no
      chr3150262250TexonicENST00000479209.1ENSG00000120742SERP1--T->G; het; QUAL=97;DP=24T->C; het; QUAL=49;DP=22--nonsynonymous SNVnonsynonymous SNVno rs idno
      chr3152022890Cintronic----C->T; hom; QUAL=140;DP=8C->T; hom; QUAL=7.8;DP=1----rs6784925no
      chr315456343TexonicENST00000383789.5ENSG00000206562METTL6--T->C; hom; QUAL=41.8;DP=2T->C; hom; QUAL=10.4;DP=1--synonymous SNVsynonymous SNVno rs idno
      chr315886992Aintronic----A->T; hom; QUAL=93.5;DP=4A->T; hom; QUAL=184;DP=8----rs7611203no
      chr3160968086AexonicENST00000472947.1ENSG00000169251NMD3--A->G; hom; QUAL=50;DP=3A->G; het; QUAL=96;DP=14--synonymous SNVsynonymous SNVno rs idno
      chr3171175289Gintronic----G->A; hom; QUAL=123;DP=7G->A; hom; QUAL=141;DP=9----rs80307611no
      chr317200091TUTR3----T->C; hom; QUAL=68;DP=3T->C; hom; QUAL=35.8;DP=2----rs7610560no
      chr3176912899Cintronic----C->T; het; QUAL=114;DP=33C->T; hom; QUAL=36.8;DP=2----rs12493005no
      chr3176912910Aintronic----A->G; het; QUAL=129;DP=33A->G; hom; QUAL=7.8;DP=1----rs12486557no
      chr3178905519Gintronic----G->A; hom; QUAL=57;DP=3G->A; hom; QUAL=222;DP=14----rs7650809no
      chr3186529064GncRNA_exonic----G->C; hom; QUAL=7.8;DP=1G->C; hom; QUAL=7.8;DP=1----no rs idno
      chr3190024856GUTR3----G->A; hom; QUAL=119;DP=6G->A; het; QUAL=145;DP=31----rs1060679no
      chr327416999TUTR3----T->C; hom; QUAL=10.4;DP=1T->C; hom; QUAL=41.8;DP=2----rs1051545no
      chr331647716Gintronic----G->A; hom; QUAL=10.4;DP=1G->A; hom; QUAL=172;DP=9----rs9812889no
      chr33193388Tintronic----T->G; hom; QUAL=83.5;DP=4T->G; hom; QUAL=57;DP=3----rs1669345no
      chr332208195GUTR3----G->A; hom; QUAL=57;DP=3G->A; hom; QUAL=83.5;DP=4----rs115291555no
      chr346717492CUTR3----C->G; hom; QUAL=7.8;DP=1C->G; hom; QUAL=7.8;DP=1----rs4683269no
      chr347453659GexonicENST00000265562.4ENSG00000076201PTPN23--G->T; hom; QUAL=45.8;DP=2G->T; het; QUAL=118;DP=7--synonymous SNVsynonymous SNVrs147959396no
      chr350041313Cintronic----C->T; hom; QUAL=138;DP=10C->T; hom; QUAL=38.8;DP=2----rs6765484no
      chr350146094Tintronic----T->A; hom; QUAL=71.5;DP=4T->A; hom; QUAL=33;DP=3----rs3733133no
      chr356944019Tintronic----T->C; hom; QUAL=126;DP=7T->C; hom; QUAL=110;DP=6----rs9882574no
      chr357306961GUTR3----G->A; hom; QUAL=164;DP=8G->A; hom; QUAL=172;DP=8----rs1913302no
      chr357564748Tintronic----T->G; hom; QUAL=115;DP=6T->G; hom; QUAL=166;DP=13----rs13063507no
      chr359999690Tintronic----T->C; hom; QUAL=35.8;DP=2T->C; hom; QUAL=7.8;DP=1----rs13067835no
      chr369070563AncRNA_UTR3----A->C; hom; QUAL=10.4;DP=1A->C; hom; QUAL=7.8;DP=1----rs1053555no
      chr373116437CUTR3----C->G; hom; QUAL=66;DP=3C->G; hom; QUAL=188;DP=12----rs1122474no
      chr398307696TexonicENST00000264193.2ENSG00000080819CPOX--T->G; hom; QUAL=46;DP=3T->G; het; QUAL=225;DP=33--nonsynonymous SNVnonsynonymous SNVrs1131857no
      chr410117728Gintronic----G->A; hom; QUAL=7.8;DP=1G->A; hom; QUAL=102;DP=5----rs35782983no
      chr4106336119Aintronic----A->G; hom; QUAL=161;DP=11A->G; hom; QUAL=7.8;DP=1----rs2713822no
      chr4123131035AexonicENST00000388738.3ENSG00000138688KIAA1109--A->G; het; QUAL=86;DP=35A->G; het; QUAL=12.3;DP=15--nonsynonymous SNVnonsynonymous SNVno rs idno
      chr41240299Tintronic----T->G; hom; QUAL=52.5;DP=5T->G; hom; QUAL=116;DP=6----rs730831no
      chr413224988Gintergenic----G->T; hom; QUAL=158;DP=11G->T; hom; QUAL=45.8;DP=2----rs4834938no
      chr413610206TexonicENST00000040738.5ENSG00000038219BOD1L1--T->G; hom; QUAL=133;DP=14T->G; hom; QUAL=128;DP=12--nonsynonymous SNVnonsynonymous SNVno rs idno
      chr41380033AUTR3----A->G; hom; QUAL=42.8;DP=2A->G; hom; QUAL=151;DP=10----rs6838561no
      chr4139086857GncRNA_UTR3----G->A; hom; QUAL=66;DP=3G->A; het; QUAL=108;DP=20----rs386495068no
      chr4139092719AncRNA_exonic----A->G; hom; QUAL=151;DP=6A->G; het; QUAL=92;DP=12----rs13120371no
      chr4139100372CexonicENST00000280612.5ENSG00000151012SLC7A11--C->T; hom; QUAL=222;DP=27C->T; hom; QUAL=97.3;DP=5--synonymous SNVsynonymous SNVrs386593325no
      chr4139103520AexonicENST00000280612.5ENSG00000151012SLC7A11--A->G; het; QUAL=61;DP=16A->C; het; QUAL=53;DP=31--synonymous SNVnonsynonymous SNVno rs idno
      chr4139110577Aintronic----A->G; hom; QUAL=7.8;DP=1A->G; hom; QUAL=130;DP=7----rs6537201no
      chr4139120683Tintronic----T->C; hom; QUAL=156;DP=14T->C; hom; QUAL=68;DP=3----rs4863772no
      chr4139127861Aintronic----A->G; hom; QUAL=222;DP=20A->G; hom; QUAL=222;DP=14----rs12506333no
      chr4139155376Cintronic----C->T; hom; QUAL=106;DP=4C->T; hom; QUAL=10.4;DP=1----rs6826686no
      chr414476023GncRNA_exonic----G->A; het; QUAL=71;DP=29G->T; het; QUAL=20;DP=8----no rs idno
      chr4170169748Aintronic----A->G; hom; QUAL=89.3;DP=5A->G; hom; QUAL=99.3;DP=5----rs144817324no
      chr4170947720Aintronic----A->C; hom; QUAL=67.5;DP=4A->C; hom; QUAL=38.8;DP=2----rs78685422no
      chr425793813Aintronic----A->T; het; QUAL=4.77;DP=1A->T; hom; QUAL=122;DP=6----rs11944026no
      chr439455756GUTR3----G->T; het; QUAL=48;DP=15G->T; het; QUAL=63;DP=22----no rs idno
      chr439532887CncRNA_intronic----C->T; hom; QUAL=221;DP=10C->T; hom; QUAL=138;DP=11----rs13137317no
      chr439551008TncRNA_intronic----T->C; hom; QUAL=119;DP=6T->C; hom; QUAL=106;DP=5----no rs idno
      chr439551179TncRNA_exonic----T->C; hom; QUAL=110;DP=7T->C; hom; QUAL=222;DP=18----no rs idno
      chr439738205Cintronic----C->T; hom; QUAL=38.8;DP=2C->T; hom; QUAL=48.8;DP=2----rs386578842no
      chr440464231Gintronic----G->A; hom; QUAL=10.4;DP=1G->A; hom; QUAL=99.3;DP=5----rs278948no
      chr457219613CexonicENST00000513376.1ENSG00000157426AASDH--C->T; hom; QUAL=38.8;DP=2C->T; hom; QUAL=10.4;DP=1--stopgain SNVstopgain SNVrs17086696no
      chr457774176CUTR5----C->G; hom; QUAL=159;DP=18C->G; hom; QUAL=28.8;DP=2----rs781654no
      chr47050377Cintronic----C->A; hom; QUAL=222;DP=12C->A; hom; QUAL=53;DP=3----rs9985704no
      chr47057106GUTR3----G->C; hom; QUAL=89.5;DP=4G->C; hom; QUAL=161;DP=21----rs10937782no
      chr476589145Cintronic----C->T; hom; QUAL=120;DP=7C->T; hom; QUAL=10.4;DP=1----rs62321018no
      chr477102182GexonicENST00000264896.2ENSG00000138760SCARB2--G->C; het; QUAL=71;DP=39G->C; het; QUAL=25;DP=96--synonymous SNVsynonymous SNVno rs idno
      chr483821324AncRNA_exonic----A->G; het; QUAL=136;DP=33A->G; het; QUAL=225;DP=40----rs2305876no
      chr484526275TUTR3----T->C; hom; QUAL=77.1;DP=6T->C; hom; QUAL=41.8;DP=2----rs1521531no
      chr488083107TUTR3----T->C; hom; QUAL=94.3;DP=5T->C; hom; QUAL=53;DP=4----rs3193672no
      chr51091373Aintronic----A->G; hom; QUAL=222;DP=36A->G; hom; QUAL=50;DP=3----rs4975658no
      chr5118627271Aintronic----A->G; hom; QUAL=156;DP=12A->G; hom; QUAL=153;DP=10----rs1966479no
      chr5118645920Gintronic----G->C; hom; QUAL=153;DP=10G->C; hom; QUAL=23.8;DP=2----rs6879919no
      chr5126868434Cintronic----C->A; hom; QUAL=117;DP=6C->A; hom; QUAL=71.5;DP=4----rs173025no
      chr5132202399TUTR5----T->C; hom; QUAL=69.5;DP=4T->C; hom; QUAL=85.3;DP=5----rs30178no
      chr5137910129Aintronic----A->T; hom; QUAL=171;DP=22A->T; hom; QUAL=74.5;DP=4----rs256009no
      chr5138318158Gintronic----G->A; hom; QUAL=170;DP=13G->A; hom; QUAL=87.5;DP=4----rs11747454no
      chr5138659158Tintronic----T->C; hom; QUAL=222;DP=20T->C; hom; QUAL=133;DP=7----rs6866346no
      chr5139559099Tintronic----T->C; hom; QUAL=222;DP=12T->C; hom; QUAL=32.8;DP=2----rs11750863no
      chr5140987771Tintronic----T->C; hom; QUAL=126;DP=7T->C; hom; QUAL=113;DP=7----no rs idno
      chr5141714412TncRNA_intronic----T->C; hom; QUAL=162;DP=12T->C; hom; QUAL=222;DP=34----rs6870020no
      chr51478156Cintronic----C->T; hom; QUAL=125;DP=8C->T; hom; QUAL=198;DP=10----rs4975548no
      chr5150402490Gintronic----G->C; hom; QUAL=45.8;DP=2G->C; hom; QUAL=10.4;DP=1----rs3792796no
      chr516784019Gintronic----G->A; hom; QUAL=110;DP=6G->A; hom; QUAL=143;DP=6----rs386570097no
      chr5177560565GUTR5----G->A; hom; QUAL=7.8;DP=1G->A; hom; QUAL=7.8;DP=1----rs7380947no
      chr5179130988Gintronic----G->A; hom; QUAL=162;DP=11G->A; hom; QUAL=41.8;DP=2----rs9329087no
      chr5179131013Cintronic----C->T; hom; QUAL=113;DP=22C->T; hom; QUAL=95.5;DP=4----rs35320050no
      chr5179228070Gintronic----G->A; hom; QUAL=157;DP=21G->A; hom; QUAL=72;DP=3----no rs idno
      chr5179259030Gintronic----G->A; hom; QUAL=102;DP=5G->A; hom; QUAL=81.5;DP=4----rs269445no
      chr5279434Gintronic----G->A; hom; QUAL=222;DP=14G->A; hom; QUAL=103;DP=7----rs12515562no
      chr532159329Aintronic----A->G; hom; QUAL=139;DP=8A->G; hom; QUAL=140;DP=8----rs661309no
      chr540830927CUTR3----C->T; hom; QUAL=123;DP=16C->T; hom; QUAL=14.9;DP=2----rs1631660no
      chr549964256Cintronic----C->A; hom; QUAL=56;DP=4C->A; het; QUAL=109;DP=13----no rs idno
      chr549964333Gintronic----G->C; hom; QUAL=41.8;DP=2G->C; hom; QUAL=143;DP=8----no rs idno
      chr552286010CncRNA_exonic----C->T; hom; QUAL=7.8;DP=1C->T; hom; QUAL=75;DP=3----rs26681no
      chr552389428AUTR3----A->G; het; QUAL=53;DP=7A->G; het; QUAL=225;DP=76----rs6880055no
      chr552389455AUTR3----A->G; het; QUAL=118;DP=11A->G; het; QUAL=225;DP=99----rs7719848no
      chr565120144TUTR3----T->C; hom; QUAL=20;DP=10T->C; hom; QUAL=111;DP=4----rs10096no
      chr565453185Aintronic----A->G; hom; QUAL=41.8;DP=2A->G; hom; QUAL=10.4;DP=1----rs27086no
      chr567529747Tintronic----T->C; hom; QUAL=41.8;DP=2T->C; hom; QUAL=10.4;DP=1----rs386688818no
      chr572858024Tintronic----T->C; het; QUAL=92;DP=7T->C; hom; QUAL=74.5;DP=4----no rs idno
      chr576787808Gintronic----G->C; hom; QUAL=135;DP=11G->C; hom; QUAL=74.5;DP=4----rs41104no
      chr594175381Tintronic----T->C; hom; QUAL=112;DP=7T->C; hom; QUAL=32.8;DP=2----rs386569371no
      chr6101271991Aintronic----A->G; hom; QUAL=41.8;DP=2A->G; hom; QUAL=142;DP=9----no rs idno
      chr6108241013Aintronic----A->G; hom; QUAL=156;DP=16A->G; hom; QUAL=92.3;DP=5----rs2179346no
      chr610825471Tintronic----T->C; hom; QUAL=174;DP=21T->C; hom; QUAL=16.9;DP=2----rs3857545no
      chr611194976GncRNA_intronic----G->T; hom; QUAL=183;DP=25G->T; hom; QUAL=154;DP=14----rs3798729no
      chr611195061CncRNA_intronic----C->G; hom; QUAL=183;DP=25C->G; hom; QUAL=91.3;DP=5----rs3798730no
      chr6159188128Aintronic----A->G; hom; QUAL=74.5;DP=4A->G; hom; QUAL=11.8;DP=4----rs2242318no
      chr6160211700Cintronic----C->G; hom; QUAL=30.8;DP=2C->G; hom; QUAL=125;DP=10----rs9355278no
      chr616415621Gintronic----G->A; hom; QUAL=142;DP=8G->A; hom; QUAL=7.8;DP=1----rs113755256no
      chr616415733Tintronic----T->G; hom; QUAL=139;DP=8T->G; het; QUAL=4.77;DP=1----rs6932569no
      chr616458226Tintronic----T->C; hom; QUAL=87.5;DP=4T->C; hom; QUAL=86.5;DP=4----rs139864180no
      chr616595948Gintronic----G->A; hom; QUAL=109;DP=4G->A; hom; QUAL=55.1;DP=6----rs236932no
      chr616732291Aintronic----A->G; hom; QUAL=158;DP=15A->G; hom; QUAL=10.4;DP=1----rs1150638no
      chr6170061736Aintronic----A->G; hom; QUAL=162;DP=12A->G; hom; QUAL=87.5;DP=4----rs73240748no
      chr618225882TUTR3----T->C; het; QUAL=100;DP=22T->G; het; QUAL=63;DP=10----no rs idno
      chr62095234Tintronic----T->C; hom; QUAL=156;DP=15T->C; hom; QUAL=35.8;DP=2----rs2026446no
      chr62369733CncRNA_intronic----C->G; hom; QUAL=123;DP=7C->G; hom; QUAL=66;DP=3----rs4296927no
      chr627357308Tintronic----T->C; hom; QUAL=77.5;DP=4T->C; hom; QUAL=83.5;DP=4----rs6904883no
      chr627357456Gintronic----G->C; hom; QUAL=77.5;DP=4G->C; hom; QUAL=41.8;DP=2----rs6925606no
      chr630131349TUTR5----T->C; hom; QUAL=222;DP=20T->C; hom; QUAL=142;DP=12----rs369834849no
      chr630580620Tintronic----T->C; hom; QUAL=102;DP=6T->C; hom; QUAL=151;DP=13----rs118183872no
      chr631233643Tintergenic----T->C; hom; QUAL=146;DP=9T->C; hom; QUAL=28.8;DP=4----no rs idno
      chr63157399Aintronic----A->G; hom; QUAL=7.8;DP=1A->G; hom; QUAL=41.8;DP=2----rs909962no
      chr633244255TUTR3----T->G; het; QUAL=4.77;DP=46T->A; het; QUAL=35;DP=22----no rs idno
      chr633613367Gintronic----G->T; hom; QUAL=66;DP=3G->T; hom; QUAL=10.4;DP=2----rs9394158no
      chr633634636Cintronic----C->T; hom; QUAL=40.5;DP=4C->T; hom; QUAL=138;DP=9----rs9357163no
      chr633658534Gintronic----G->A; hom; QUAL=7.8;DP=1G->A; hom; QUAL=63.5;DP=4----rs10947430no
      chr634385241TUTR3----T->G; het; QUAL=32;DP=8T->C; het; QUAL=96;DP=27----rs112078820no
      chr635378778CUTR5----C->T; hom; QUAL=222;DP=31C->T; hom; QUAL=155;DP=14----rs2016520no
      chr642664658GUTR3----G->A; hom; QUAL=45.8;DP=2G->A; hom; QUAL=85.5;DP=4----rs405043no
      chr642664676GUTR3----G->A; hom; QUAL=45.8;DP=2G->A; hom; QUAL=76.5;DP=4----rs405059no
      chr642753404Gintronic----G->A; hom; QUAL=48.8;DP=2G->A; hom; QUAL=42.8;DP=2----rs2894478no
      chr67237463Tintronic----T->C; hom; QUAL=138;DP=9T->C; hom; QUAL=118;DP=7----rs2714334no
      chr674303531TUTR3----T->C; het; QUAL=51;DP=18T->C; het; QUAL=11.3;DP=8----no rs idno
      chr675776984Aintergenic----A->G; hom; QUAL=163;DP=8A->G; hom; QUAL=7.8;DP=1----rs726242no
      chr676325096Gintronic----G->A; hom; QUAL=143;DP=11G->A; hom; QUAL=156;DP=14----rs478934no
      chr7100731505CexonicENST00000306085.6ENSG00000169871TRIM56--C->G; hom; QUAL=23.8;DP=2C->G; hom; QUAL=161;DP=7--synonymous SNVsynonymous SNVrs4524722no
      chr7100734758Aintronic----A->G; hom; QUAL=146;DP=9A->G; hom; QUAL=101;DP=5----no rs idno
      chr7101860931Aintronic----A->T; hom; QUAL=85.5;DP=4A->T; hom; QUAL=10.4;DP=1----rs372968no
      chr71067403Gintronic----G->A; hom; QUAL=7.8;DP=1G->A; hom; QUAL=23.8;DP=2----rs74360401no
      chr711133357Tintronic----T->C; hom; QUAL=142;DP=10T->C; hom; QUAL=63;DP=3----rs2906543no
      chr7117834049Aintergenic----A->G; hom; QUAL=142;DP=8A->G; hom; QUAL=7.8;DP=1----rs11543742no
      chr71195215AexonicENST00000316495.3ENSG00000178381ZFAND2A--A->C; hom; QUAL=222;DP=30A->C; het; QUAL=125;DP=10--synonymous SNVsynonymous SNVrs1133116no
      chr7127005073Cintergenic----C->G; hom; QUAL=27.8;DP=2C->G; hom; QUAL=77.5;DP=4----rs1361940no
      chr7127715902Tintronic----T->C; hom; QUAL=222;DP=10T->C; hom; QUAL=131;DP=7----rs322832no
      chr7128224522GncRNA_intronic----G->T; hom; QUAL=162;DP=11G->T; hom; QUAL=190;DP=8----rs62479757no
      chr7130567807TncRNA_intronic----T->C; hom; QUAL=85.5;DP=4T->C; hom; QUAL=10.4;DP=1----rs157911no
      chr7130578993GncRNA_intronic----G->C; hom; QUAL=80.5;DP=4G->C; hom; QUAL=85.1;DP=6----rs157923no
      chr7130582489GncRNA_intronic----G->A; hom; QUAL=160;DP=12G->A; hom; QUAL=135;DP=6----rs205757no
      chr7130590540GncRNA_intronic----G->T; hom; QUAL=38.8;DP=2G->T; het; QUAL=4.77;DP=1----rs205762no
      chr7130598236GncRNA_intronic----G->T; hom; QUAL=222;DP=19G->T; hom; QUAL=101;DP=6----rs205764no
      chr7130602136GncRNA_intronic----G->C; hom; QUAL=85.5;DP=4G->C; hom; QUAL=38.8;DP=2----rs157952no
      chr7130611079CncRNA_intronic----C->T; hom; QUAL=35.8;DP=2C->T; hom; QUAL=41.8;DP=2----rs139326117no
      chr7130616236CncRNA_exonic----C->A; hom; QUAL=222;DP=14C->A; hom; QUAL=7.8;DP=1----rs205716no
      chr7130623437Cintergenic----C->T; hom; QUAL=7.8;DP=1C->T; hom; QUAL=112;DP=7----rs205725no
      chr7134870201TUTR3----T->C; hom; QUAL=38.5;DP=4T->C; hom; QUAL=184;DP=32----rs8345no
      chr7140193194Gintergenic----G->A; hom; QUAL=10.4;DP=1G->A; het; QUAL=5.46;DP=2----rs386718471no
      chr7140193213Aintergenic----A->G; het; QUAL=4.77;DP=1A->G; het; QUAL=3.55;DP=3----rs4726837no
      chr7148427590Aintronic----A->T; hom; QUAL=160;DP=6A->T; hom; QUAL=94.3;DP=5----rs6464923no
      chr7148721233Gintronic----G->A; hom; QUAL=83.5;DP=4G->A; hom; QUAL=83.3;DP=5----rs6948711no
      chr7148725750Cupstream----C->T; hom; QUAL=126;DP=7C->T; hom; QUAL=7.8;DP=1----rs2306170no
      chr71579371Cintronic----C->T; hom; QUAL=32.8;DP=2C->T; hom; QUAL=150;DP=7----rs3824071no
      chr7158416979Tupstream----T->C; hom; QUAL=108;DP=6T->C; hom; QUAL=128;DP=7----no rs idno
      chr7158572652Aintronic----A->G; hom; QUAL=38.8;DP=2A->G; hom; QUAL=77.5;DP=4----rs712191no
      chr72063476Tintronic----T->C; hom; QUAL=41.8;DP=2T->C; hom; QUAL=63;DP=3----rs6973622no
      chr727650526Aintronic----A->G; het; QUAL=4.77;DP=1A->G; het; QUAL=100;DP=11----rs62454870no
      chr72767077Gdownstream----G->A; hom; QUAL=38.8;DP=4G->A; hom; QUAL=215;DP=25----rs798535no
      chr728134636Tintronic----T->A; hom; QUAL=180;DP=22T->A; hom; QUAL=83.5;DP=4----no rs idno
      chr729286334Aintronic----A->G; hom; QUAL=63;DP=3A->G; hom; QUAL=10.4;DP=1----rs39092no
      chr730499575TUTR5----T->C; hom; QUAL=41.8;DP=2T->C; hom; QUAL=116;DP=5----rs2906766no
      chr730617474TncRNA_exonic----T->C; hom; QUAL=183;DP=8T->C; hom; QUAL=42.8;DP=2----rs38488no
      chr732548931Tintronic----T->A; hom; QUAL=169;DP=14T->A; hom; QUAL=10.4;DP=1----rs375591519no
      chr732768526GncRNA_exonic----G->A; hom; QUAL=159;DP=11G->A; hom; QUAL=35.8;DP=3----rs2893435no
      chr732968136GncRNA_intronic----G->A; hom; QUAL=157;DP=9G->A; hom; QUAL=38.8;DP=2----rs4720085no
      chr742958092GUTR3----G->A; hom; QUAL=10.4;DP=1G->A; hom; QUAL=41.8;DP=2----rs638171no
      chr744098142Cintronic----C->T; hom; QUAL=31;DP=16C->T; hom; QUAL=10.4;DP=1----rs11773481no
      chr745025542CncRNA_exonic----C->T; hom; QUAL=222;DP=17C->T; hom; QUAL=221;DP=12----rs3213657no
      chr74795277Aintronic----A->G; hom; QUAL=63;DP=3A->G; hom; QUAL=79.3;DP=5----no rs idno
      chr74801973GexonicENST00000446823.1ENSG00000164916FOXK1--G->A; hom; QUAL=96.1;DP=6G->A; hom; QUAL=122;DP=6--nonsynonymous SNVnonsynonymous SNVrs15715no
      chr748128901TUTR5----T->C; hom; QUAL=173;DP=35T->C; hom; QUAL=222;DP=57----rs3763504no
      chr748132391Cintronic----C->T; het; QUAL=4.77;DP=1C->T; hom; QUAL=170;DP=14----rs9639019no
      chr748136339Tintronic----T->C; hom; QUAL=7.8;DP=1T->C; hom; QUAL=135;DP=11----rs7385009no
      chr748140799Gintronic----G->T; hom; QUAL=155;DP=11G->T; hom; QUAL=100;DP=5----rs13228276no
      chr750661917Aintronic----A->G; hom; QUAL=7.8;DP=1A->G; hom; QUAL=108;DP=12----rs376051131no
      chr750673029TexonicENST00000398810.2ENSG00000106070GRB10--T->C; hom; QUAL=222;DP=29T->C; hom; QUAL=222;DP=32--nonsynonymous SNVnonsynonymous SNVrs4947710down
      chr750837579Gintronic----G->C; hom; QUAL=116;DP=6G->C; hom; QUAL=106;DP=5----rs757776no
      chr75445756Tintronic----T->C; hom; QUAL=94.3;DP=5T->C; hom; QUAL=156;DP=7----rs10252168no
      chr755134819Aintronic----A->G; hom; QUAL=68;DP=3A->G; hom; QUAL=38.8;DP=2----rs723526no
      chr755278852CUTR3----C->A; hom; QUAL=7.8;DP=2C->A; het; QUAL=159;DP=14----rs7334no
      chr75539958Cintronic----C->T; hom; QUAL=97.3;DP=5C->T; hom; QUAL=134;DP=8----rs7799622no
      chr75542513Tintronic----T->C; hom; QUAL=109;DP=5T->C; hom; QUAL=7.8;DP=1----rs386602891no
      chr756033424Cintronic----C->T; hom; QUAL=160;DP=17C->T; hom; QUAL=10.4;DP=1----rs112132543no
      chr756033558Aintronic----A->G; hom; QUAL=132;DP=9A->G; hom; QUAL=222;DP=17----rs4470984no
      chr7564438GncRNA_intronic----G->A; het; QUAL=4.77;DP=2G->A; hom; QUAL=75.3;DP=5----rs143872265no
      chr7564581GncRNA_exonic----G->A; hom; QUAL=101;DP=6G->A; hom; QUAL=134;DP=6----rs9770574no
      chr75955010Cintronic----C->T; hom; QUAL=6.19;DP=12C->T; hom; QUAL=17.8;DP=2----rs141468817no
      chr763781804Tintronic----T->C; hom; QUAL=174;DP=16T->C; hom; QUAL=158;DP=11----rs599238no
      chr763802516Aintronic----A->G; hom; QUAL=91.5;DP=4A->G; hom; QUAL=77.5;DP=4----rs1404678no
      chr763821145Cintergenic----C->T; hom; QUAL=54;DP=3C->T; hom; QUAL=38.8;DP=2----rs6460142no
      chr76449272AUTR3----A->G; hom; QUAL=165;DP=29A->G; het; QUAL=157;DP=42----rs386606722no
      chr76510642Gintronic----G->A; hom; QUAL=38.8;DP=2G->A; hom; QUAL=127;DP=6----rs147919565no
      chr77238096Aintronic----A->G; hom; QUAL=120;DP=7A->G; hom; QUAL=35.8;DP=2----rs149033305no
      chr77250370Aintronic----A->T; hom; QUAL=7.8;DP=1A->T; hom; QUAL=178;DP=23----rs59388279no
      chr77267787Gintronic----G->T; hom; QUAL=10.4;DP=1G->T; hom; QUAL=7.8;DP=1----rs6960832no
      chr774173182TncRNA_UTR3----T->A; hom; QUAL=35.8;DP=2T->A; het; QUAL=88;DP=10----rs2069301no
      chr775047944GUTR3----G->A; hom; QUAL=109;DP=8G->A; het; QUAL=55;DP=27----rs376495903no
      chr776111835GexonicENST00000429179.1ENSG00000091073DTX2--G->A; hom; QUAL=57;DP=3G->A; hom; QUAL=121;DP=7--synonymous SNVsynonymous SNVrs4236506no
      chr78073359Tintronic----T->A; hom; QUAL=143;DP=8T->A; hom; QUAL=66;DP=3----rs4725056no
      chr78073459Tintronic----T->C; hom; QUAL=143;DP=8T->C; hom; QUAL=60;DP=3----rs4725057no
      chr791726927AexonicENST00000394534.2ENSG00000127914AKAP9--A->C; het; QUAL=225;DP=19A->C; hom; QUAL=7.8;DP=1--synonymous SNVsynonymous SNVrs1063243no
      chr791742348CUTR3----C->A; hom; QUAL=109;DP=4C->A; hom; QUAL=45.8;DP=2----rs57122389no
      chr797498573Aintronic----A->C; het; QUAL=52;DP=5A->C; hom; QUAL=104;DP=5----no rs idno
      chr799050323Gintronic----G->A; hom; QUAL=123;DP=7G->A; hom; QUAL=7.8;DP=1----rs45540134no
      chr8112195730CncRNA_exonic----C->T; het; QUAL=3.54;DP=3C->T; hom; QUAL=119;DP=7----rs201823686no
      chr8112195737TncRNA_exonic----T->C; hom; QUAL=41.8;DP=2T->C; hom; QUAL=113;DP=7----no rs idno
      chr812052475GncRNA_exonic----G->C; hom; QUAL=7.8;DP=1G->C; hom; QUAL=35.8;DP=2----rs76672192no
      chr8121742641Tintronic----T->C; hom; QUAL=103;DP=4T->C; hom; QUAL=60;DP=3----no rs idno
      chr8128822709AncRNA_intronic----A->G; hom; QUAL=162;DP=19A->G; hom; QUAL=188;DP=9----rs10108514no
      chr8141656396Cintergenic----C->T; hom; QUAL=41.8;DP=2C->T; hom; QUAL=131;DP=8----rs11775532no
      chr8142218119GUTR3----G->A; hom; QUAL=169;DP=19G->A; hom; QUAL=66;DP=3----rs2288999no
      chr8144350854Aintronic----A->G; hom; QUAL=123;DP=8A->G; hom; QUAL=173;DP=17----rs1075645no
      chr8144363094CncRNA_exonic----C->A; hom; QUAL=41.8;DP=2C->A; hom; QUAL=222;DP=20----rs4419827no
      chr8144363134CncRNA_exonic----C->T; hom; QUAL=45.8;DP=2C->T; hom; QUAL=151;DP=10----no rs idno
      chr8144777073CUTR3----C->T; hom; QUAL=28.8;DP=2C->T; hom; QUAL=10.4;DP=1----rs61348167no
      chr8145530644Tintronic----T->C; hom; QUAL=77.3;DP=5T->C; hom; QUAL=7.8;DP=1----rs7814279no
      chr8145651262TUTR3----T->C; hom; QUAL=7.8;DP=1T->C; hom; QUAL=222;DP=17----rs2272658no
      chr816850498CUTR3----C->G; hom; QUAL=169;DP=14C->G; hom; QUAL=176;DP=16----rs1721100no
      chr816858781Gintronic----G->A; hom; QUAL=123;DP=8G->A; hom; QUAL=214;DP=10----rs17514943no
      chr817549493Tintronic----T->C; hom; QUAL=115;DP=6T->C; hom; QUAL=10.4;DP=1----rs182363no
      chr818870837Tintronic----T->G; hom; QUAL=35.8;DP=2T->G; hom; QUAL=10.4;DP=1----rs73594632no
      chr822927642CncRNA_intronic----C->G; hom; QUAL=86.5;DP=4C->G; hom; QUAL=161;DP=11----rs144853747no
      chr822927696TncRNA_intronic----T->C; hom; QUAL=35.8;DP=2T->C; hom; QUAL=222;DP=22----rs113574384no
      chr823018906Aintronic----A->C; hom; QUAL=42.8;DP=2A->C; hom; QUAL=41.8;DP=2----rs202171880no
      chr829934036Aintronic----A->G; hom; QUAL=129;DP=8A->G; hom; QUAL=7.8;DP=1----rs4733316no
      chr837922447Aintergenic----A->G; hom; QUAL=168;DP=14A->G; hom; QUAL=7.8;DP=1----no rs idno
      chr841475106AncRNA_intronic----A->T; hom; QUAL=106;DP=5A->T; hom; QUAL=48.8;DP=2----rs11784433no
      chr848890247AUTR3----A->G; het; QUAL=108;DP=18A->G; het; QUAL=143;DP=24----rs1135031no
      chr852766522Aintronic----A->G; hom; QUAL=160;DP=18A->G; hom; QUAL=96.3;DP=5----rs4618684no
      chr856686035CUTR5----C->T; hom; QUAL=118;DP=7C->T; hom; QUAL=147;DP=10----rs2044812no
      chr862560784Cintronic----C->T; hom; QUAL=175;DP=17C->T; hom; QUAL=156;DP=14----rs2350588no
      chr862570278Gintronic----G->T; hom; QUAL=142;DP=9G->T; hom; QUAL=146;DP=10----rs67189750no
      chr863941217Tintronic----T->C; hom; QUAL=195;DP=8T->C; hom; QUAL=10.4;DP=1----rs3824333no
      chr88192229Aintronic----A->C; hom; QUAL=68;DP=3A->C; hom; QUAL=170;DP=14----rs2945908no
      chr88222192Tintronic----T->G; het; QUAL=128;DP=10T->G; hom; QUAL=75;DP=3----rs11996133no
      chr882748674Tintronic----T->A; hom; QUAL=155;DP=32T->A; hom; QUAL=32.8;DP=2----rs12674735no
      chr89506176Cintronic----C->T; hom; QUAL=175;DP=17C->T; hom; QUAL=222;DP=11----rs6601341no
      chr895273529Cintronic----C->T; hom; QUAL=122;DP=8C->T; hom; QUAL=69.3;DP=5----rs12386916no
      chr9127623432Tintronic----T->A; hom; QUAL=7.8;DP=2T->A; hom; QUAL=125;DP=11----rs3780594no
      chr912821837AUTR3----A->C; hom; QUAL=140;DP=8A->C; het; QUAL=153;DP=16----no rs idno
      chr9130567656Aintronic----A->T; hom; QUAL=46;DP=3A->T; hom; QUAL=154;DP=10----rs10819307no
      chr9130704975TUTR3----T->C; hom; QUAL=158;DP=34T->C; hom; QUAL=87.5;DP=4----rs3818510no
      chr9130742762AUTR5----A->C; hom; QUAL=142;DP=10A->C; hom; QUAL=13;DP=2----rs79356092no
      chr9130951342Tintronic----T->A; hom; QUAL=80.5;DP=4T->A; hom; QUAL=77.5;DP=4----rs12684314no
      chr9131018542TUTR3----T->C; het; QUAL=226;DP=18T->C; het; QUAL=9.52;DP=15----rs77168744no
      chr9131444773Tupstream----T->C; hom; QUAL=222;DP=20T->C; het; QUAL=115;DP=11----no rs idno
      chr9131897551Aintronic----A->G; het; QUAL=55;DP=16A->G; hom; QUAL=89.5;DP=4----no rs idno
      chr9132268255TncRNA_intronic----T->C; hom; QUAL=151;DP=10T->C; hom; QUAL=222;DP=11----rs1780457no
      chr9134330523AexonicENST00000458550.1ENSG00000130723PRRC2B--A->C; het; QUAL=72;DP=36A->G; het; QUAL=110;DP=29--nonsynonymous SNVnonsynonymous SNVno rs iddown
      chr9136196161Gintergenic----G->C; hom; QUAL=60;DP=3G->C; hom; QUAL=87.5;DP=4----rs12056960no
      chr9139118673TexonicENST00000358701.5ENSG00000165661QSOX2--T->C; hom; QUAL=222;DP=29T->C; het; QUAL=201;DP=19--nonsynonymous SNVnonsynonymous SNVrs12380852no
      chr9139270876GexonicENST00000298532.2ENSG00000165684SNAPC4--G->A; het; QUAL=110;DP=11G->A; hom; QUAL=176;DP=24--nonsynonymous SNVnonsynonymous SNVrs3812561no
      chr9139371786AexonicENST00000313050.7ENSG00000148396SEC16A--A->C; hom; QUAL=39.5;DP=4A->C; het; QUAL=225;DP=58--synonymous SNVsynonymous SNVrs6560632no
      chr9139616742AexonicENST00000371692.4ENSG00000165716FAM69B--A->G; hom; QUAL=24;DP=9A->G; hom; QUAL=10.4;DP=1--nonsynonymous SNVnonsynonymous SNVrs945384no
      chr9139902214AUTR3----A->G; hom; QUAL=144;DP=12A->G; hom; QUAL=125;DP=7----rs10870161no
      chr9140178902Tintergenic----T->C; hom; QUAL=80.5;DP=4T->C; hom; QUAL=7.8;DP=1----rs7857229no
      chr9140449582AUTR3----A->C; hom; QUAL=94.3;DP=5A->C; het; QUAL=4.77;DP=1----rs10110no
      chr9140459873Aintronic----A->G; hom; QUAL=72;DP=3A->G; hom; QUAL=151;DP=6----rs140876555no
      chr9149210Gintronic----G->T; hom; QUAL=35.8;DP=2G->T; hom; QUAL=54;DP=6----rs200587022no
      chr9149299Gintronic----G->C; hom; QUAL=63;DP=3G->C; het; QUAL=133;DP=16----no rs idno
      chr919099459Cintronic----C->T; hom; QUAL=142;DP=10C->T; hom; QUAL=222;DP=12----rs28753724no
      chr921591540Tintergenic----T->C; hom; QUAL=177;DP=19T->C; het; QUAL=4.77;DP=1----rs1869207no
      chr933025503Gintronic----G->A; hom; QUAL=113;DP=9G->A; hom; QUAL=118;DP=5----rs2297216no
      chr933111764GUTR3----G->A; het; QUAL=49;DP=28G->A; het; QUAL=61;DP=28----rs17326539no
      chr933111788TUTR3----T->C; het; QUAL=113;DP=21T->C; het; QUAL=87;DP=34----rs16918998no
      chr937441650TexonicENST00000307750.4ENSG00000168795ZBTB5--T->C; het; QUAL=14.2;DP=14T->C; hom; QUAL=35.8;DP=2--nonsynonymous SNVnonsynonymous SNVrs17502738no
      chr95461394Aintronic----A->G; hom; QUAL=104;DP=5A->G; hom; QUAL=87.5;DP=4----rs10123377no
      chr97033514Aintronic----A->G; hom; QUAL=89.5;DP=4A->G; hom; QUAL=7.8;DP=1----rs386586631no
      chr970647441CUTR3----C->T; hom; QUAL=131;DP=10C->T; het; QUAL=52;DP=6----no rs idno
      chr970647448CUTR3----C->A; hom; QUAL=113;DP=10C->A; het; QUAL=44;DP=6----no rs idno
      chr974361312Cintronic----C->T; het; QUAL=66;DP=10C->T; het; QUAL=76.1;DP=6----rs41316488no
      chr985669972CUTR3----C->T; het; QUAL=124;DP=20C->T; het; QUAL=5.46;DP=26----no rs idno
      chr986267142Tintergenic----T->G; hom; QUAL=170;DP=13T->G; hom; QUAL=38.8;DP=2----rs2811924no
      chr995892443Aintronic----A->T; hom; QUAL=106;DP=5A->T; hom; QUAL=38.8;DP=2----rs6479454no
      chr996305564AexonicENST00000333936.5ENSG00000048828FAM120A--A->G; het; QUAL=33;DP=15A->G; het; QUAL=39;DP=25--nonsynonymous SNVnonsynonymous SNVno rs idno
      chr997795421Gintronic----G->A; hom; QUAL=65.3;DP=5G->A; hom; QUAL=104;DP=4----rs6479591no
      chr997873435Gintronic----G->A; hom; QUAL=158;DP=20G->A; hom; QUAL=130;DP=7----rs2404457no
      chr999278021AexonicENST00000412285.2ENSG00000081377CDC14B--A->C; het; QUAL=89.1;DP=8A->C; hom; QUAL=115;DP=6--nonsynonymous SNVnonsynonymous SNVno rs idno
      chrX106206508Aintronic----A->C; hom; QUAL=106;DP=5A->C; hom; QUAL=162;DP=12----rs386826801no
      chrX106206578Aintronic----A->G; hom; QUAL=106;DP=5A->G; hom; QUAL=222;DP=24----rs1927310no
      chrX117907853AexonicENST00000371666.3ENSG00000131724IL13RA1--A->G; het; QUAL=75;DP=9A->G; het; QUAL=53;DP=14--nonsynonymous SNVnonsynonymous SNVno rs idno
      chrX132437337GexonicENST00000370828.3ENSG00000076716GPC4--G->A; hom; QUAL=222;DP=15G->A; hom; QUAL=156;DP=11--nonsynonymous SNVnonsynonymous SNVrs1048369down
      chrX150840895GexonicENST00000370357.4ENSG00000166049PASD1--G->A; het; QUAL=40;DP=15G->T; het; QUAL=96.1;DP=12--nonsynonymous SNVstopgain SNVno rs idno
      chrX152613112CexonicENST00000421401.3ENSG00000063587ZNF275--C->T; hom; QUAL=60;DP=3C->T; hom; QUAL=7.8;DP=1--synonymous SNVsynonymous SNVrs7066295no
      chrX153582327TexonicENST00000422373.1ENSG00000196924FLNA--T->C; hom; QUAL=222;DP=52T->C; hom; QUAL=222;DP=131--stoploss SNVstoploss SNVno rs idno
      chrX23804947Cdownstream----C->G; hom; QUAL=32.8;DP=2C->G; hom; QUAL=89.5;DP=4----rs2002277no
      chrX37301047GncRNA_exonic----G->A; hom; QUAL=10.4;DP=1G->A; hom; QUAL=107;DP=6----no rs idno
      chrX3785364GncRNA_exonic----G->T; het; QUAL=100;DP=10G->T; hom; QUAL=104;DP=12----no rs idno
      chrX4460606Gintergenic----G->C; hom; QUAL=64;DP=24G->A; hom; QUAL=111;DP=12----rs146683290no
      chrX67262833AUTR3----A->T; het; QUAL=134;DP=33A->T; het; QUAL=85;DP=18----no rs idno
      chrX67735048Aintronic----A->G; hom; QUAL=7.8;DP=1A->G; hom; QUAL=10.4;DP=1----no rs idno
      chrX73463312TncRNA_intronic----T->C; hom; QUAL=7.8;DP=1T->C; het; QUAL=4.13;DP=22----no rs idno
      chrX77220327AncRNA_exonic----A->G; hom; QUAL=30.8;DP=2A->G; hom; QUAL=10.4;DP=1----no rs idno

      Table S1.  RNA-Seq results showed 929 SNPs between the gastric cancer cell lines AGS and AGS-EBV

      EBVnGCsexagetumor locationtumor sizehistological classificationLymph node metastasis
      male64Gastric antrum4×3cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      male50 Gastric body4×9cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      male52Lesser curvature side6×6cmUlcerative Adenocarcinoma, low differentiationPorta hepatis LN metastasis
      male38Lesser curvature sided=10cmUlcerative Adenocarcinoma, high differentiationLesser curvature side LN metatasis
      male55Gastric angled=3cmUlcerative Adenocarcinoma, medium-low differentiationLN metastasis
      female75Gastric antrumd=4cmUlcerative Mucous Adenocarcinoma, low differentiationNo LN metastasis
      female54 Gastric body2×3.5cm, 4×3cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      male38Gastric antrum9×6cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      female75Lesser curvature side9×7cmUlcerative Adenocarcinoma, low differentiationGreater curvature side LN metastasis
      male47Gastric angle5×4cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      male38Gastric angled=2cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      female64Cardia3×4cmUlcerative Mucous Adenocarcinoma, medium differentiationLN metastasis
      male80Gastric angle3×3cmUlcerative Adenocarcinoma, medium differentiationNo LN metastasis
      female38Gastric angled=2.5cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      female44Gastric antrum3×2cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      male59Gastric antrum9×7cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      male38Lesser curvature sided=7cmUlcerative Adenocarcinoma, low differentiationGreater and lesser curvature side LN metastasis
      male74Cardia8×3cmUlcerative signet ring cell carcinomaLesser curvature side LN metatasis
      female67Stomach5.5×6cmUlcerative Mucous Adenocarcinoma, low differentiationGreater and lesser curvature side LN metastasis
      female27Lesser curvature side8×5cmUlcerative Adenocarcinoma, low differentiationGreater and lesser curvature side LN metastasis
      male57Gastric antrumd=3cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      female40Gastric antrumd=4.5cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      female61Gastric antrumd=5.5cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      female71Lesser curvature sided=3cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      male54Gastric antrum8×6cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      male57Gastric antrum5.5×5cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      male60Lesser curvature side4×3.5cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      male52Lesser curvature sided=4cmUlcerative Adenocarcinoma, low differentiationGreater curvature side LN metastasis
      male44Gastric antrum5×5cmUlcerative Adenocarcinoma, medium differentiationNo LN metastasis
      male68Gastric antrum6×3.5cmUlcerative Adenocarcinoma, medium differentiationGreater and lesser curvature side LN metastasis
      female58Pylorus4×3cmUlcerative Mucous Adenocarcinoma, low differentiationLN metastasis
      male72Cardiad=2cmUlcerative Adenocarcinoma, medium differentiationNo LN metastasis
      male36Gastric antrumd=6cmUlcerative Adenocarcinoma, low differentiationLesser curvature side LN metatasis
      male41Gastric antrumd=5cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      female73Close cut edge 2.5 cmd=3cmUlcerative Adenocarcinoma, low differentiationGreater and lesser curvature side LN metastasis
      male68Cardia5.5×5cmUlcerative Adenocarcinoma, low differentiationLesser curvature side LN metatasis
      male35Pylorusd=5cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      male67Gastric angled=7cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      male48Gastric antrum5×5cmUlcerative Adenocarcinoma, low differentiationGreater and lesser curvature side LN metastasis
      male51Gastric antrum6×6cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      male49Lesser curvature side9×9cmProtruded Adenocarcinoma, medium differentiationLN metastasis
      male59Lesser curvature sided=8cmDiffuse infiltrating Adenocarcinoma, low differentiationGreater and lesser curvature side LN metastasis
      male56Lesser curvature side6×5cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      male72Gastric antrum6×6cmUlcerative Adenocarcinoma, low differentiationLesser curvature side LN metatasis
      male52Gastric antrumd=4cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      male59Gastric antrumd=4cmUlcerative Adenocarcinoma, low differentiationGreater and lesser curvature side LN metastasis
      male53Gastric antrumd=4cmDiffuse infiltrating Adenocarcinoma, low differentiationGreater and lesser curvature side LN metastasis
      female64Gastric antrum4×3.5cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      male54Gastric antrum5×6cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      female78Gastric antrum4.5×4cmUlcerative Adenocarcinoma, low differentiationGreater and lesser curvature side LN metastasis
      male49Gastric antrum5×3cmUlcerative Adenocarcinoma, low differentiation
      male60Gastric antrum9×8cmUlcerative Adenocarcinoma, low differentiationGreater and lesser curvature side LN metastasis
      female67Lesser curvature side10×9cmUlcerative Adenocarcinoma, low differentiationGreater and lesser curvature side LN metastasis
      male50Gastric antrum4.5×4cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      male63Gastric cardiac8×7cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      female58Near cut edge 1 cm and far cut edge 5 cmmd=5.5cmUlcerative Adenocarcinoma, low differentiationGreater and lesser curvature side LN metastasis
      male72Near cut edge 0.5m and far cut edge 2 cmm9×5.5cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      male63Stomach fanterior walld=6cmUlcerative Adenocarcinoma, low differentiationLesser curvature side LN metatasis
      female73Gastric antrum8×7cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      male63Sbtomach, lymph nodes, esophagus4×3cmUlcerative Adenocarcinoma, medium differentiationLesser curvature side LN metatasis
      male73Upper stomach body5×3.5cmFungating Adenocarcinoma, low differentiationGreater curvature side LN metastasis
      male68Stomach close cardia8×12cmUlcerative Adenocarcinoma, low differentiationLesser curvature side LN metatasis
      male75Gastric pyloric antrum5×4cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      male55Sbtomach8×7cmUlcerative Adenocarcinoma, low differentiationGreater and lesser curvature side LN metastasis
      female72Greater curvature side6×5cmUlcerative Adenocarcinoma, low differentiationGreater and lesser curvature side LN metastasis
      male40Sbtomachd=4cmUlcerative Adenocarcinoma, low differentiationGreater and lesser curvature side LN metastasis
      female80Gastric antrum5×3.5cmUlcerative Adenocarcinoma, medium differentiationNo LN metastasis
      male56Gastric antrum4×4cmUlcerative Papillary AdenocarcinomaNo LN metastasis
      male62Pylorus front wall3.5×4.5(3)Ulcerative signet ring cell carcinoma, high differentiation AdenocarcinomaLN metastasis
      male47Gastric antrum5.5×3×2cmHybrid mucous cell carcinomaGreater and lesser curvature side LN metastasis
      male78Gastric antrum5×6cmUlcerative Tubular Adenocarcinoma, medium differentiationLN metastasis
      male72Gastric antrum6×6cmUlcerative Tubular Adenocarcinoma, medium differentiationLN metastasis
      male60Gastric antrum5×4cmUlcerative Mucous AdenocarcinomaLN metastasis
      male54Gastric antrum4×5cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      male57Gastric antrum8×8cmUlcerative Mucous AdenocarcinomaLN metastasis
      male78Sbtomach14×9cmDiffuse infiltrating Adenocarcinoma, low differentiationLN metastasis
      male62Gastric antrum4×4cmUlcerative Carcinoma, medium differentiationLN metastasis
      male64Gastric antrum4×4cmUlcerative Adenocarcinoma, high differentiationLN metastasis
      male78 fundus of stomachd=3cmUlcerative Adenocarcinoma, low differentiationLesser curvature side LN metatasis
      female82Gastric antrum6.5×5cmUlcerative Adenocarcinoma, medium differentiationLN metastasis
      male66Gastric angled=7cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      EBVaGCmale43Gastric antrum, Gastric body4×6cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      female51Cardia8×4cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      female62Lesser curvature side7×5cmUlcerative Adenocarcinoma, low differentiationGreater curvature side LN metastasis
      female59Remnant stomachd=9cmUlcerative Adenocarcinoma, low differentiationLesser curvature side LN metatasis
      male26Gastric antrumd=4cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      male57 Gastric body4×4.5cmUlcerative Adenocarcinoma, low differentiationLesser curvature side LN metatasis
      male43Remnant stomach4cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      male75Gastric antrum8×4cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      male44Gastric antrumd=7cmUlcerative Adenocarcinoma, low differentiationLesser curvature side LN metatasis
      male52 Cardia and fundus10×9cmUlcerative Adenocarcinoma, low differentiationGreater and lesser curvature side LN metastasis
      female42 Gastric bodyd=3.5cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      male69Gastric antrum7×4cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      male47Lesser curvature side4×3cmDiffuse infiltrating Adenocarcinoma, low differentiationGreater and lesser curvature side LN metastasis
      male44Gastric antrum8×5cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      male60Pylorus front wall9×10cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      male41Remnant stomach13×12cmUlcerative Adenocarcinoma, medium differentiationLN metastasis
      male77Lesser curvature side14×12cmUlcerative infiltrating Adenocarcinoma, low differentiationLN metastasis
      male61Lesser curvature side4.5×2×2Ulcerative Adenocarcinoma, low differentiationLN metastasis
      male62Lesser curvature side4.2×3×1Ulcerative AdenocarcinomaNo LN metastasis
      male55Lesser curvature side4×5×1.2Signet ring cell carcinomaLN metastasis
      male55Gastric antrum8×7.5cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      male52 Gastric body10×8.5Ulcerative Adenocarcinoma, low differentiationNo LN metastasis
      male55Lesser curvature side7×5cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      male67 Gastric bodyd=6cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      male70Gastric antrum5×5cmAdenocarcinoma, low differentiationLN metastasis
      male63Cardia5.5×2.5cmAdenocarcinoma, low differentiationNo LN metastasis
      male40Lesser curvature side4×3Adenocarcinoma, low differentiationLN metastasis
      male69Lesser curvature side9.5×7cmUlcerative Adenocarcinoma, medium-low differentiationGreater and lesser curvature side LN metastasis
      male52Lesser curvature side2.6×3.8cmAdenocarcinoma, medium differentiationLN metastasis
      female43Lesser curvature sideS 5.5×1cmAdenocarcinoma, medium-low differentiationLN metastasis
      female44 Gastric bodyS 5.5×1.0cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      male51CardiaS 7×1.2cmDiffuse infiltrating Adenocarcinoma, low differentiationLN metastasis
      female69 Gastric bodyS 3.5×2.0㎝Adenocarcinoma, low differentiationNo LN metastasis
      male50 Gastric bodyS 7×5.5㎝Adenocarcinoma, low differentiationCardiac branch into the esophagus
      male48 Gastric bodyS 7.5×5.5㎝Adenocarcinoma, low differentiationLesser curvature side LN metatasis
      male58 Gastric bodyS 6.5×6㎝Adenocarcinoma, low differentiationGreater curvature side LN metastasis
      male42 Gastric bodyS 7×5㎝Adenocarcinoma, low differentiationGreater and lesser curvature side LN metastasis
      male55Gastric antrum9×2-4.5Adenocarcinoma, low differentiationLN metastasis
      male37Gastric antrum6×3.8×3.2Infiltrating Adenocarcinoma, low differentiationLN metastasis
      male57Gastric antrum10.5×10×2Ulcerative Mucous AdenocarcinomaLN metastasis
      female54Gastric antrum6.5×6×1.5Ulcerative Adenocarcinoma, low differentiationLN metastasis
      male61Gastric antrum6.6×4×2.5cmAdenocarcinoma, low differentiationLN metastasis
      male63Lesser curvature side5.5×2.5cmAdenocarcinoma, low differentiationNo LN metastasis
      male44Lesser curvature side6.5×5cmAdenocarcinoma, low differentiationGreater and lesser curvature side LN metastasis
      male70Lesser curvature side10×9cmAdenocarcinoma, low differentiationGreater and lesser curvature side LN metastasis
      male48Lesser curvature side9.5×6cmUlcerative Adenocarcinoma, low differentiationLesser curvature side LN metatasis
      male78Lesser curvature side6×5cmUlcerative Adenocarcinoma, low differentiationLesser curvature side LN metatasis
      male56Remnant stomach9×8cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      male64Gastric antrum5×4cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      male54Gastric antrum9×8cmUlcerative Adenocarcinoma, low differentiationLesser curvature side LN metatasis
      male55 Cardia and fundus6×6cmUlcerative Adenocarcinoma, low differentiationGreater and lesser curvature side LN metastasis
      female48 Gastric body11×7cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      male37Gastric antrum4.5×3cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      male37Gastric antrum7×6cmUlcerative Adenocarcinoma, low differentiationGreater and lesser curvature side LN metastasis
      male78Gastric antrum6.5×6cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      female61Lesser curvature side5.5×4cmUlcerative Adenocarcinoma, low differentiationLN metastasis
      female63Lesser curvature side5.5×5cmUlcerative Mucous AdenocarcinomaLN metastasis
      male56 Gastric bodyd=3cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      female43Gastric antrumd=4cmAdenocarcinoma, low differentiationGreater and lesser curvature side LN metastasis
      male46Gastric antrum4.5×3.5cmAdenocarcinoma, low differentiationGreater and lesser curvature side LN metastasis
      male59Gastric antrum5×3cmUlcerative AdenocarcinomaLN metastasis
      male70Cardiad=2cmSignet ring cell carcinomaLN metastasis
      male64Lesser curvature sided=2.5cmUlcerative Adenocarcinoma, low differentiationNo LN metastasis
      male42Lesser curvature side6×5cmUlcerative Adenocarcinoma, low differentiationGreater and lesser curvature side LN metastasis

      Table S2.  Detail information for EBVaGC/EBVnGC patients and healthy controls

    Figure (3)  Table (7) Reference (47) Relative (20)

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