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Volume 32 Issue 1
February 2017
    Citation: Yi Wang, Ping Zhang. Recent advances in the identification of the host factors involved in dengue virus replication .VIROLOGICA SINICA, 2017, 32(1) : 23-31.  http://dx.doi.org/10.1007/s12250-016-3902-6
    shu

    Recent advances in the identification of the host factors involved in dengue virus replication

    • 1.

      Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China

    • 2.

      Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou 510080, China

    • Corresponding author: Ping Zhang, zhangp36@mail.sysu.edu.cn, ORCID: 0000-0002-5400-8767
    • Received Date: 03 November 2016
      Accepted Date: 04 January 2017
      Published Date: 24 January 2017
      Available online: 01 February 2017
    • Dengue virus (DENV) belongs to the genus Flavivirus of the family Flaviviridae and it is primarily transmitted via Aedes aegypti and Aedes albopictus mosquitoes. The life cycle of DENV includes attachment, endocytosis, protein translation, RNA synthesis, assembly, egress, and maturation. Recent researches have indicated that a variety of host factors, including cellular proteins and microRNAs, positively or negatively regulate the DENV replication process. This review summarizes the latest findings (from 2014 to 2016) in the identification of the host factors involved in the DENV life cycle and Dengue infection.
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      Recent advances in the identification of the host factors involved in dengue virus replication

        Corresponding author: Ping Zhang, zhangp36@mail.sysu.edu.cn
      • 1. Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China
      • 2. Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou 510080, China
      • Received Date: 03 November 2016
      • Accepted Date: 04 January 2017
      • Published Date: 24 January 2017

      Abstract: Dengue virus (DENV) belongs to the genus Flavivirus of the family Flaviviridae and it is primarily transmitted via Aedes aegypti and Aedes albopictus mosquitoes. The life cycle of DENV includes attachment, endocytosis, protein translation, RNA synthesis, assembly, egress, and maturation. Recent researches have indicated that a variety of host factors, including cellular proteins and microRNAs, positively or negatively regulate the DENV replication process. This review summarizes the latest findings (from 2014 to 2016) in the identification of the host factors involved in the DENV life cycle and Dengue infection.

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