Modulation of Antiviral Immunity and Therapeutic Efficacy by 25-Hydroxycholesterol in Chronically SIV-Infected, ART-Treated Rhesus Macaques

Chunxiu Wu; Jin Zhao; Ruiting Li; Fengling Feng; Yizi He; Yanjun Li; Runhan Huang; Guangye Li; Heng Yang; Genhong Cheng; Ling Chen; Feng Ma; Pingchao Li; Caijun Sun

doi:10.1007/s12250-021-00407-6

October 2021

Citation: Chunxiu Wu, Jin Zhao, Ruiting Li, Fengling Feng, Yizi He, Yanjun Li, Runhan Huang, Guangye Li, Heng Yang, Genhong Cheng, Ling Chen, Feng Ma, Pingchao Li, Caijun Sun. Modulation of Antiviral Immunity and Therapeutic Efficacy by 25-Hydroxycholesterol in Chronically SIV-Infected, ART-Treated Rhesus Macaques .VIROLOGICA SINICA, 2021, 36(5) : 1197-1209. http://dx.doi.org/10.1007/s12250-021-00407-6

Modulation of Antiviral Immunity and Therapeutic Efficacy by 25-Hydroxycholesterol in Chronically SIV-Infected, ART-Treated Rhesus Macaques

Chunxiu Wu ^1,4 ,
Jin Zhao ^2,3 ,
Ruiting Li ^2,3 ,
Fengling Feng ^2,3 ,
Yizi He ^1,4 ,
Yanjun Li ^2,3 ,
Runhan Huang ² ,
Guangye Li ⁸ ,
Heng Yang ^5,6 ,
Genhong Cheng ^5,6,7 ,
Ling Chen ^1,4 ,
Feng Ma ^{5,6
,,} ,
Pingchao Li ^{1
,,} ,
Caijun Sun ^{2,3
,,}

1.
State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, 510530, China
2.
School of Public Health (Shenzhen), Sun Yat-Sen University, Guangdong, 518107, China
3.
Key Laboratory of Tropical Disease Control, Sun Yat-Sen University, Ministry of Education, Guangzhou, 514400, China
4.
University of Chinese Academy of Sciences, Beijing, 100049, China
5.
Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China
6.
Suzhou Institute of Systems Medicine, Suzhou, 215123, China
7.
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 90095, USA
8.
Guangdong Landau Biotechnology Co. Ltd, Guangzhou, 510700, China

Corresponding author: Feng Ma, maf@ism.pumc.edu.cn, ORCID: http://orcid.org/0000-0002-2975-0118
Pingchao Li, li_pingchao@gibh.ac.cn, ORCID: http://orcid.org/0000-0001-5046-0855
Caijun Sun, suncaijun@mail.sysu.edu.cn, ORCID: http://orcid.org/0000-0002-2000-7053