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Citation: Mengyuan Li, Jiali Yang, Chuantao Ye, Peiyu Bian, Xiaofei Yang, Haijun Zhang, Chuanyu Luo, Zhifeng Xue, Yingfeng Lei, Jianqi Lian. Correction to: Integrated Metabolomics and Transcriptomics Analyses Reveal Metabolic Landscape in Neuronal Cells During JEV Infection [J].VIROLOGICA SINICA, 2021, 36(6) : 1693-1694.  http://dx.doi.org/10.1007/s12250-021-00468-7

Correction to: Integrated Metabolomics and Transcriptomics Analyses Reveal Metabolic Landscape in Neuronal Cells During JEV Infection


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      沈阳化工大学材料科学与工程学院 沈阳 110142

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    Correction to: Integrated Metabolomics and Transcriptomics Analyses Reveal Metabolic Landscape in Neuronal Cells During JEV Infection

      Corresponding author: Yingfeng Lei, yflei@fmmu.edu.cn
      Corresponding author: Jianqi Lian, lianjq@fmmu.edu.cn
    • 1. Department of Infectious Diseases, Tangdu Hospital, Air Force Medical University, Xi'an 710038, China
    • 2. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi'an 710069, China
    • 3. Department of Neurology, Xijing Hospital, Air Force Medical University, Xi'an 710032, China
    • 4. Pathogenic Biology, Medical College of Yan'an University, Yan'an 716000, China
    • 5. Department of Microbiology, School of Preclinical Medicine, Air Force Medical University, Xi'an 710032, China

    Abstract: 

    • Correction to: Virologica Sinica

      https://doi.org/10.1007/s12250-021-00445-0

      In the original version of this article, one image in Fig. 4 was accidently duplicated during figure layout and the dilution rate was mislabeled. The correct Fig. 4 and its legend are given below:

      Figure 4.  PPP is indispensable for JEV replication. A Heatmap analysis of significantly changed metabolites associated with purine and pyrimidine metabolism. BG Intervention of PPP by 6-AN significantly inhibits JEV replication in Neuro2a cell line and mouse primary neurons at 24 hpi. JEV mRNA levels in JEV-infected Neuro2a cells (B) and mouse primary neurons (E) treated with 6-AN at 24 hpi were detected by qPCR analysis. The level of mRNA expression was normalized with β-actin. The expression levels of viral protein NS3 in JEV-infected Neuro2a cells (C) and mouse primary neurons (F) were detected by Western blot analysis. Plaque formation assay shows the reduction of plaque generation in JEV-infected Neuro2a cells (D) and mouse primary neurons (G). 103, 104, 105 and 106 represented the dilution rate. H qPCR analysis of JEV mRNA level shows that anaplerosis of D-ribose 5-phosphate under 6-AN treatment condition could partially restore the viral replication. *P < 0.05; **P < 0.01

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