Citation: Jia Li, Yong Lin, Xueyu Wang, Mengji Lu. Interconnection of cellular autophagy and endosomal vesicle trafficking and its role in hepatitis B virus replication and release .VIROLOGICA SINICA, 2024, 39(1) : 24-30.  http://dx.doi.org/10.1016/j.virs.2024.01.001

Interconnection of cellular autophagy and endosomal vesicle trafficking and its role in hepatitis B virus replication and release

  • Corresponding author: Mengji Lu, mengji.lu@uni-due.de
  • Received Date: 07 September 2023
    Accepted Date: 06 January 2024
    Available online: 09 January 2024
  • Hepatitis B virus (HBV) produces and releases various particle types, including complete virions, subviral particles with envelope proteins, and naked capsids. Recent studies demonstrate that HBV exploits distinct intracellular membrane trafficking pathways, including the endosomal vesicle trafficking and autophagy pathway, to assemble and release viral and subviral particles. Herein, we summarize the findings about the distinct roles of autophagy and endosomal membrane trafficking and the interaction of both pathways in HBV replication, assembly, and release.

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    Interconnection of cellular autophagy and endosomal vesicle trafficking and its role in hepatitis B virus replication and release

      Corresponding author: Mengji Lu, mengji.lu@uni-due.de
    • a. Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, 45122, Germany;
    • b. Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), Chongqing Medical University, Chongqing, 400016, China;
    • c. The Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310000, China

    Abstract: Hepatitis B virus (HBV) produces and releases various particle types, including complete virions, subviral particles with envelope proteins, and naked capsids. Recent studies demonstrate that HBV exploits distinct intracellular membrane trafficking pathways, including the endosomal vesicle trafficking and autophagy pathway, to assemble and release viral and subviral particles. Herein, we summarize the findings about the distinct roles of autophagy and endosomal membrane trafficking and the interaction of both pathways in HBV replication, assembly, and release.

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