POTENTIATION OF INTERFERON S ANTIVIRAL ACTIVITY BY COMBINED PREPARATIONS OF HUMAN ALPHA AND GAMMA INTERFERONS
Abstract: Potentiation of interferon s antiviral activity was determined by replication inhibition of vesicular stomatitis virus in human lung cancer calls(A549). Combined preparations of human IFN-α and IFN-γ interacted with cells synergistically to cause a much grearer level of protection than that expected on the basis of their additive or multiplicative effect. The potentiation was not the artifact of an accelerated development of IFN-γ-induced antiviral resistance in the presence of IFN-α. The rest components in...