Citation: CHAN Yi-Fei, JI Hong, QIU Mu-Rui, WANG De-Bao. Anti-SRSV Activity of Antisense Oligodeoxynucleotides .VIROLOGICA SINICA, 1991, 6(1) : 33.

Anti-SRSV Activity of Antisense Oligodeoxynucleotides

  • Available online: 05 March 1991
  • Synthesized antisense oligodeoxynucleotides, including modified and unmodified, homo- and hetero-forms, were tested for their ability to inhibit mouse SRS virus-induced cellular multiplication, the formations of colonies of SRSV-infected cells and XC syneytia and RT activity. All oligomers were found to be active. Preminary studies of acute toxicity in mice showed that his compound to be nontoxic at high levels It is suggested that different classes of oligonucleotides may inhibit virus replication by diffe...

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    Anti-SRSV Activity of Antisense Oligodeoxynucleotides

    • 1. Department of Biophysics
    • 2. Shanghai Medical University
    • 3. Shanghai 200032 Shanghai Institute of Biochemistry

    Abstract: Synthesized antisense oligodeoxynucleotides, including modified and unmodified, homo- and hetero-forms, were tested for their ability to inhibit mouse SRS virus-induced cellular multiplication, the formations of colonies of SRSV-infected cells and XC syneytia and RT activity. All oligomers were found to be active. Preminary studies of acute toxicity in mice showed that his compound to be nontoxic at high levels It is suggested that different classes of oligonucleotides may inhibit virus replication by diffe...

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