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Volume 24 Issue 1
February 2009
    Citation: Wei-feng SHI, Ai-she DUN, Zhong ZHANG, Yan-zhou ZHANG, Guang-fu YU, Dong-ming ZHUANG, Chao-dong ZHU. Selection Pressure on Haemagglutinin Genes of H9N2 Influenza Viruses from Different Hosts .VIROLOGICA SINICA, 2009, 24(1) : 65-70.  http://dx.doi.org/10.1007/s12250-009-2988-5
    shu

    Selection Pressure on Haemagglutinin Genes of H9N2 Influenza Viruses from Different Hosts

    cstr: 32224.14.s12250-009-2988-5
    • 1.

      Institute of Life Sciences, Taishan Medical College, Taian 271000, China

    • 2.

      Department of Basic Medicine, Taishan Medical College, Taian 271000, China

    • 3.

      Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

    • Corresponding author: Chao-dong ZHU, zhucd@ioz.ac.cn
    • Received Date: 08 August 2008
      Accepted Date: 22 October 2008
      Available online: 01 February 2009
    • Positive selection and differential selective pressure analyses were carried out to study Haemagglutinin (HA) genes of H9N2 influenza viruses from different hosts in this paper. Results showed that, although most positions in HAs were under neutral or purifying evolution, a few positions located in the antigenic regions and receptor binding sites were subject to positive selection and some of them were even positively selected at the population level. In addition, there were always some positions differentially selected for viruses from different hosts. Both selection pressure working on HA codons and positions differentially selected might account for the extension of the host range and adaptations to different hosts of H9N2 influenza viruses.
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      7. Guan Y, Shortridge K F, Krauss S, et al. 2000. Molecular characterization of H9N2 influenza viruses: Were they the donors of the "internal" genes of H5N1 viruses in Hong Kong? Proc Natl Acad Sci USA, 96: 9363-9367.

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      Selection Pressure on Haemagglutinin Genes of H9N2 Influenza Viruses from Different Hosts

        Corresponding author: Chao-dong ZHU, zhucd@ioz.ac.cn
      • 1. Institute of Life Sciences, Taishan Medical College, Taian 271000, China
      • 2. Department of Basic Medicine, Taishan Medical College, Taian 271000, China
      • 3. Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
      • Received Date: 08 August 2008
      • Accepted Date: 22 October 2008

      Abstract: Positive selection and differential selective pressure analyses were carried out to study Haemagglutinin (HA) genes of H9N2 influenza viruses from different hosts in this paper. Results showed that, although most positions in HAs were under neutral or purifying evolution, a few positions located in the antigenic regions and receptor binding sites were subject to positive selection and some of them were even positively selected at the population level. In addition, there were always some positions differentially selected for viruses from different hosts. Both selection pressure working on HA codons and positions differentially selected might account for the extension of the host range and adaptations to different hosts of H9N2 influenza viruses.

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