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Volume 24 Issue 5
October 2009
    Citation: Cohen David P. A., Marek Martin, Davies Bryn G., Vlak Just M., Monique M. van Oers. Encyclopedia of Autographa californica Nucleopolyhedrovirus Genes .VIROLOGICA SINICA, 2009, 24(5) : 359-414.  http://dx.doi.org/10.1007/s12250-009-3059-7
    shu

    Encyclopedia of Autographa californica Nucleopolyhedrovirus Genes

    • 1.

      Wageningen University, Laboratory of Virolo, Box 629, 6700AP wageningen, The Netherlands

    • 2.

      Généthon, Department of Bioprocess Development, Evry, France

    • 3.

      University of York, YCR Cancer Research, Dept. of Biology, Heslington, York, United Kingdom

    • Received Date: 31 January 2009
      Accepted Date: 18 May 2009
      Available online: 01 October 2009

      Fund Project: The project BACULOGENES of the European Union LSHB-CT-2006-037541

    • The Autographa californica multiple capsid nucleopolyhedrovirus (AcMNPV) was the first baculovirus for which the complete nucleotide sequence became known. Since then 15 years lapsed and much research has been performed to elucidate putative functions of the annotated open reading frames of this virus and this endeavour is still ongoing. AcMNPV is the most well-known and well-studied baculovirus species, not in the least for its application as a vector for the high-level expression of foreign genes in insect cells. This article is the first monograph of a single baculovirus and gives a current overview of what is known about the 151 AcMNPV ORFs, including (putative) function and temporal and spatial presence of transcripts and protein. To date 60 ORFs have a proven function, another 19 ORFs have homologs for which functions are known in other baculoviruses and 72 ORFs are still enigmatic. This paper should assist the reader in quickly finding the essentials of AcMNPV.
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      Encyclopedia of Autographa californica Nucleopolyhedrovirus Genes

      • 1. Wageningen University, Laboratory of Virolo, Box 629, 6700AP wageningen, The Netherlands
      • 2. Généthon, Department of Bioprocess Development, Evry, France
      • 3. University of York, YCR Cancer Research, Dept. of Biology, Heslington, York, United Kingdom
      • Received Date: 31 January 2009
      • Accepted Date: 18 May 2009
      Fund Project:  The project BACULOGENES of the European Union LSHB-CT-2006-037541

      Abstract: The Autographa californica multiple capsid nucleopolyhedrovirus (AcMNPV) was the first baculovirus for which the complete nucleotide sequence became known. Since then 15 years lapsed and much research has been performed to elucidate putative functions of the annotated open reading frames of this virus and this endeavour is still ongoing. AcMNPV is the most well-known and well-studied baculovirus species, not in the least for its application as a vector for the high-level expression of foreign genes in insect cells. This article is the first monograph of a single baculovirus and gives a current overview of what is known about the 151 AcMNPV ORFs, including (putative) function and temporal and spatial presence of transcripts and protein. To date 60 ORFs have a proven function, another 19 ORFs have homologs for which functions are known in other baculoviruses and 72 ORFs are still enigmatic. This paper should assist the reader in quickly finding the essentials of AcMNPV.

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