Citation: Yue Lu, Ping He, Yuxuan Zhang, Yongwen Ren, Leiliang Zhang. The emerging roles of retromer and sorting nexins in the life cycle of viruses .VIROLOGICA SINICA, 2022, 37(3) : 321-330.

The emerging roles of retromer and sorting nexins in the life cycle of viruses

  • Corresponding author: Leiliang Zhang,
  • Received Date: 28 December 2021
    Accepted Date: 12 April 2022
    Available online: 02 May 2022
  • Retromer and sorting nexins (SNXs) transport cargoes from endosomes to the trans-Golgi network or plasma membrane. Recent studies have unveiled the emerging roles for retromer and SNXs in the life cycle of viruses, including members of Coronaviridae, Flaviviridae and Retroviridae. Key components of retromer/SNXs, such as Vps35, Vps26, SNX5 and SNX27, can affect multiple steps of the viral life cycle, including facilitating the entry of viruses into cells, participating in viral replication, and promoting the assembly of virions. Here we present a comprehensive updated review on the interplay between retromer/SNXs and virus, which will shed mechanistic insights into controlling virus infection.

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    The emerging roles of retromer and sorting nexins in the life cycle of viruses

      Corresponding author: Leiliang Zhang,
    • a Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250013, China;

    Abstract: Retromer and sorting nexins (SNXs) transport cargoes from endosomes to the trans-Golgi network or plasma membrane. Recent studies have unveiled the emerging roles for retromer and SNXs in the life cycle of viruses, including members of Coronaviridae, Flaviviridae and Retroviridae. Key components of retromer/SNXs, such as Vps35, Vps26, SNX5 and SNX27, can affect multiple steps of the viral life cycle, including facilitating the entry of viruses into cells, participating in viral replication, and promoting the assembly of virions. Here we present a comprehensive updated review on the interplay between retromer/SNXs and virus, which will shed mechanistic insights into controlling virus infection.

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