Identification and characterization of a novel ulcerative enteritis-associated adenovirus of quail causing cross-species infection in chickens

Hui Tang; Yin Shi; Qing Zhang; Fei Zhu; Jia-Yao Hou; Jing-Ying Liao; Yi-Shuai Zhang; Chang-Xin Jing; Xin-Qi Liu; Chao-Ting Xiao

doi:10.1016/j.virs.2026.04.002

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Volume 41 Issue 2

April 2026

Citation: Hui Tang, Yin Shi, Qing Zhang, Fei Zhu, Jia-Yao Hou, Jing-Ying Liao, Yi-Shuai Zhang, Chang-Xin Jing, Xin-Qi Liu, Chao-Ting Xiao. Identification and characterization of a novel ulcerative enteritis-associated adenovirus of quail causing cross-species infection in chickens .VIROLOGICA SINICA, 2026, 41(2) : 474-477. http://dx.doi.org/10.1016/j.virs.2026.04.002

Identification and characterization of a novel ulcerative enteritis-associated adenovirus of quail causing cross-species infection in chickens

College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan Research Center of the Basic Discipline for Cell Signaling, Hunan University, Changsha 410082, China

Corresponding author: Chao-Ting Xiao, xiaocht@hnu.edu.cn
Received Date: 13 December 2025
Accepted Date: 07 April 2026
Available online: 10 April 2026

Abstract

Highlights
1 A quail siadenovirus (QAdV-1) was identified to be associated with ulcerative enteritis-like disease.
2 QAdV-1 is a novel member of the genus Siadenovirus in the family Adenoviridae.
3 QAdV-1 shows the highest identity to Turkey hemorrhagic enteritis virus.
4 Animal studies evidenced that QAdV-1 is pathogenic to quails and can transmit cross-species to chickens.

Electronic Supplementary Material

10.1016j.virs.2026.04.002-ESM.docx
References
1. Benko, M., Aoki, K., Arnberg, N., Davison, A.J., Echavarria, M., Hess, M., Jones, M.S., Kajan, G.L., Kajon, A.E., Mittal, S.K., Podgorski, I.I., San Martin, C., Wadell, G., Watanabe, H., Harrach, B., Consortium, I.R., 2022. ICTV virus taxonomy profile: adenoviridae 2022. J. Gen. Virol. 103, 001721.
2. Berkhoff, G.A., Campbell, S.G., Naylor, H.B., Smith, L.D., 1974. Etiology and pathogenesis of ulcerative enteritis (“quail disease”). Characterization of the causative anaerobe. Avian Dis. 18, 195-204.
3. Crespo, R., Franca, M., Shivaprasad, H.L., 2013. Ulcerative enteritis-like disease associated with in quail. Avian Dis. 57, 698-702.
4. Davis, R.B., Brown, J., Dawe, D.L., 1971. Quail--biological indicators in the differentiation of ulcerative and necrotic enteritis of chickens. Poult. Sci. 50, 737-740.
5. Davison, A.J., Wright, K.M., Harrach, B., 2000. DNA sequence of frog adenovirus. J. Gen. Virol. 81, 2431-2439.
6. Dhama, K., Gowthaman, V., Karthik, K., Tiwari, R., Sachan, S., Kumar, M.A., Palanivelu, M., Malik, Y.S., Singh, R.K., Munir, M., 2017. Haemorrhagic enteritis of turkeys - current knowledge. Vet Quart. 37, 31-42.
7. Harrach, B., Tarjan, Z.L., Benkő, M., 2019. Adenoviruses across the animal kingdom: a walk in the zoo. FEBS Lett. 593, 3660-3673.
8. Kovacs, E.R., Benko, M., 2011. Complete sequence of raptor adenovirus 1 confirms the characteristic genome organization of siadenoviruses. Infect. Genet. Evol. 11, 1058-1065.
9. Liao, J.Y., Tang, H., Xiong, W.J., Liu, T.N., Li, J.Y., Xia, J.Y., Xiao, C.T., 2023. Isolation and characterization of a novel goose ovaritis-associated cluster 3 tembusu virus. Poult. Sci. 102, 102867.
10. Liao, J.Y., Shi, Y., Tang, H., Fu, P., Li, J.Y., Zhang, Y.S., Wu, Q., Peng, Y.S., Xiao, C.T., 2025. Emerging and characterization of a novel fowl adenovirus 4 strain with open reading frame 19 (orf19) in diseased chickens from China. Poult. Sci. 104, 104702.
11. Liu, Y., Song, M.X., Bai, H., Wang, C.H., Wang, F., Yuan, Q., 2024. Curcumin improves the egg quality, antioxidant activity, and intestinal microbiota of quails during the late laying period. Poult. Sci. 103, 103233.
12. Musa, L., Rapi, M.C., Franciosini, M.P., Lupini, C., Catelli, E., Addis, M.F., Grilli, G., 2024. Turkey hemorrhagic enteritis (the): a short overview. Pathogens. 13, 663.
13. Postler, T.S., Rubino, L., Adriaenssens, E.M., Dutilh, B.E., Harrach, B., Junglen, S., Kropinski, A.M., Krupovic, M., Wada, J., Crane, A., Kuhn, J.H., Mushegian, A., Rumnieks, J., Sabanadzovic, S., Simmonds, P., Varsani, A., Zerbini, F.M., Callanan, J., Draper, L.A., Hill, C., Stockdale, S.R., 2022. Guidance for creating individual and batch latinized binomial virus species names. J. Gen. Virol. 103, 001800.
14. Shivaprasad, H.L., Uzal, F., Kokka, R., Fisher, D.J., McClane, B.A., Songer, A.G., 2008. Ulcerative enteritis-like disease associated with Clostridium perfringens type a in bobwhite quail (Colinus virginianus). Avian Dis. 52, 635-640.
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Identification and characterization of a novel ulcerative enteritis-associated adenovirus of quail causing cross-species infection in chickens

Corresponding author: Chao-Ting Xiao, xiaocht@hnu.edu.cn

College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan Research Center of the Basic Discipline for Cell Signaling, Hunan University, Changsha 410082, China

Received Date: 13 December 2025
Accepted Date: 07 April 2026

Abstract: Highlights
1 A quail siadenovirus (QAdV-1) was identified to be associated with ulcerative enteritis-like disease.
2 QAdV-1 is a novel member of the genus Siadenovirus in the family Adenoviridae.
3 QAdV-1 shows the highest identity to Turkey hemorrhagic enteritis virus.
4 Animal studies evidenced that QAdV-1 is pathogenic to quails and can transmit cross-species to chickens.