An Overview of the Highly Pathogenic H5N1 Influenza Virus

Jingchuan Yin; Shi Liu; Ying Zhu

doi:10.1007/s12250-013-3294-9

February 2013

Jingchuan Yin, Shi Liu and Ying Zhu. An Overview of the Highly Pathogenic H5N1 Influenza Virus[J]. Virologica Sinica, 2013, 28(1): 3-15. doi: 10.1007/s12250-013-3294-9

Citation: Jingchuan Yin, Shi Liu, Ying Zhu. An Overview of the Highly Pathogenic H5N1 Influenza Virus .VIROLOGICA SINICA, 2013, 28(1) : 3-15. http://dx.doi.org/10.1007/s12250-013-3294-9

An Overview of the Highly Pathogenic H5N1 Influenza Virus

cstr: 32224.14.s12250-013-3294-9

The State Key laboratory of Virology and College of Life Sciences, Wuhan University, Wuhan 430072, China

通讯作者： Ying Zhu, yingzhu@whu.edu.cn
收稿日期： 2012-11-14
录用日期： 2012-12-31

摘要

Since the first human case of H5N1 avian influenza virus infection was reported in 1997, this highly pathogenic virus has infected hundreds of people around the world and resulted in many deaths. The ability of H5N1 to cross species boundaries, and the presence of polymorphisms that enhance virulence, present challenges to developing clear strategies to prevent the pandemic spread of this highly pathogenic avian influenza (HPAI) virus. This review summarizes the current understanding of, and recent research on, the avian influenza H5N1 virus, including transmission, virulence, pathogenesis, clinical characteristics, treatment and prevention.
- Avian influenza
- , H5N1
- , Transmission
- , Virulence
- , Pathogenesis

An Overview of the Highly Pathogenic H5N1 Influenza Virus

The State Key laboratory of Virology and College of Life Sciences, Wuhan University, Wuhan 430072, China

Corresponding author: Ying Zhu, yingzhu@whu.edu.cn
Received Date: 14 November 2012
Accepted Date: 31 December 2012

Fund Project: National Natural Science Foundation of China 81271821National Natural Science Foundation of China 30979144

Abstract

Since the first human case of H5N1 avian influenza virus infection was reported in 1997, this highly pathogenic virus has infected hundreds of people around the world and resulted in many deaths. The ability of H5N1 to cross species boundaries, and the presence of polymorphisms that enhance virulence, present challenges to developing clear strategies to prevent the pandemic spread of this highly pathogenic avian influenza (HPAI) virus. This review summarizes the current understanding of, and recent research on, the avian influenza H5N1 virus, including transmission, virulence, pathogenesis, clinical characteristics, treatment and prevention.
- Avian influenza
- , H5N1
- , Transmission
- , Virulence
- , Pathogenesis

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