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Volume 32 Issue 3
June 2017

    Peiqi Yin, Zhi Hong, Leiliang Zhang and Youyang Ke. Retromer localizes to autophagosomes during HCV replication[J]. Virologica Sinica, 2017, 32(3): 245-248. doi: 10.1007/s12250-016-3914-2
    Citation: Peiqi Yin, Zhi Hong, Leiliang Zhang, Youyang Ke. Retromer localizes to autophagosomes during HCV replication .VIROLOGICA SINICA, 2017, 32(3) : 245-248.  http://dx.doi.org/10.1007/s12250-016-3914-2
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    逆转运复合体在丙肝病毒复制时定位于自噬体

    • 1.

      中国医学科学院/北京协和医学院，卫生部病原系统生物学重点实验室，病原生物学研究所，北京100171，中国

    • 2.

      解放军171医院急救中心，九江 332000，中国

    • 此前我们发现逆转运复合体是丙肝病毒复制所必需的，但其详细机制仍有待进一步研究。在本研究中，我们发现丙肝病毒复制时逆转运复合体定位在自噬体上。我们认为逆转运复合体参与提供了用于病毒复制的膜来源。这些结果对于逆转运复合体在丙肝复制中的作用机制有一定的启发。

    Retromer localizes to autophagosomes during HCV replication

    Retromer in HCV-induced autophagosomes

    • 1.

      MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100176, China

    • 2.

      Department of Emergency, 171st Hospital of PLA, Jiujiang 332000, China

    • In summary, we propose a model for the role of retromer in HCV replication. Upon HCV infection, retromer may provide double-membrane autophagosomal membranes for HCV replication. Our studies suggested a novel link between retromer and autophagy in HCV replication, which may provide new therapeutic targets for antiviral therapy.
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      14. Yin P, Hong Z, Yang X, et al. 2015. Cell Mol Life Sci, 73:869–881.

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      Retromer localizes to autophagosomes during HCV replication

        Corresponding author: Leiliang Zhang, armzhang@hotmail.com
        Corresponding author: Youyang Ke, keyouyang001@163.com
      • 1. MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100176, China
      • 2. Department of Emergency, 171st Hospital of PLA, Jiujiang 332000, China
      • Published Date: 13 April 2017

      Abstract: In summary, we propose a model for the role of retromer in HCV replication. Upon HCV infection, retromer may provide double-membrane autophagosomal membranes for HCV replication. Our studies suggested a novel link between retromer and autophagy in HCV replication, which may provide new therapeutic targets for antiviral therapy.

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