. doi: 10.1016/j.virs.2026.06.006
Citation: Wei Ye, Yangchao Dong, He Liu, Hongwei Ma, Yingfeng Lei, Fanglin Zhang. Hijacking the host heparan sulfate-cell-surface ribonucleoproteins (RNPs) scaffold pathway for viral immune evasion .VIROLOGICA SINICA, 2026, 41(4) : 999-1001.  http://dx.doi.org/10.1016/j.virs.2026.06.006

病毒劫持宿主硫酸乙酰肝素-细胞表面核糖核蛋白骨架通路实现免疫逃逸

  • Li和Joshi等人在Molecular Cell杂志的最新研究中,揭示了硫酸乙酰肝素作为细胞表面RNA-蛋白质复合物的关键骨架,为免疫受体的招募提供了平台。本篇评论在该发现的基础上,提出了一个病毒免疫逃逸的统一假说:多种RNA病毒的核衣壳蛋白可能通过劫持这一宿主骨架系统,在感染细胞表面实现稳定展示。这些表面展示的病毒蛋白充当高亲和力的趋化因子陷阱,通过捕获并隔离CXCL12等关键趋化因子,破坏趋化因子的浓度梯度,从而抑制先天免疫应答和适应性免疫的启动。这一劫持策略将宿主原本用于免疫调控的内源性界面,转化为病毒实现广谱免疫抑制的工具,为理解病毒与宿主在细胞表面的博弈提供了全新视角,也为开发靶向病毒-硫酸乙酰肝素相互作用的广谱抗病毒策略指明了新方向。

Hijacking the host heparan sulfate-cell-surface ribonucleoproteins (RNPs) scaffold pathway for viral immune evasion

  • Highlights
    1 Viral nucleocapsid proteins may co-opt this host scaffold for cell-surface display.
    2 Surface-displayed viral proteins can bind chemokines, suppressing immune cell recruitment.

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    Hijacking the host heparan sulfate-cell-surface ribonucleoproteins (RNPs) scaffold pathway for viral immune evasion

    Abstract: Highlights
    1 Viral nucleocapsid proteins may co-opt this host scaffold for cell-surface display.
    2 Surface-displayed viral proteins can bind chemokines, suppressing immune cell recruitment.

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