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Volume 21 Issue 2
April 2006
    Citation: XIE Li, LI Xiu-hui, ZHANG Rui-yun, XIN Yong-mei, SHI Hong-bo. Study of Severe Liver Disease in Patients Coinfected with HBV and HCV .VIROLOGICA SINICA, 2006, 21(2) : 186-188.
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    Study of Severe Liver Disease in Patients Coinfected with HBV and HCV

    • 1.

      Beijing You-an Hospital affiliated to Capital University of Medical Sciences, Beijing 100069, China

    • Corresponding author: XIE Li, 
    • Available online: 20 March 2006
    • To understand the dual infection by Hepatitis B virus (HBV) and Hepatitis C virus (HCV), and the viral interference between HBV and HCV infections, biochemical and virological markers of 196 patients were detected. Among 196 patients tested, 76 patients were only infected by HBV, 72 patients were only infected by HCV, and 48 patients were co-infected by HBV and HCV. There were no striking association of ALT in patients with HBV, HCV or co-infection. The positive rate of HBsAg and HBV DNA in patients with co-infection was obviously lower than that of HBV infection only. These results suggested that disease was more severe in patients with co-infection, prevalence of LC and HCC in patients with co-infection was higher than either infection alone. HBV and HCV inhibit the replication with each other, but HCV seems to suppress HBV replication more evidently. Key words：Hepatitis B virus(HBV); Hepatitis C virus(HCV); Co-infection
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      Study of Severe Liver Disease in Patients Coinfected with HBV and HCV

        Corresponding author: XIE Li,
      • 1. Beijing You-an Hospital affiliated to Capital University of Medical Sciences, Beijing 100069, China

      Abstract: To understand the dual infection by Hepatitis B virus (HBV) and Hepatitis C virus (HCV), and the viral interference between HBV and HCV infections, biochemical and virological markers of 196 patients were detected. Among 196 patients tested, 76 patients were only infected by HBV, 72 patients were only infected by HCV, and 48 patients were co-infected by HBV and HCV. There were no striking association of ALT in patients with HBV, HCV or co-infection. The positive rate of HBsAg and HBV DNA in patients with co-infection was obviously lower than that of HBV infection only. These results suggested that disease was more severe in patients with co-infection, prevalence of LC and HCC in patients with co-infection was higher than either infection alone. HBV and HCV inhibit the replication with each other, but HCV seems to suppress HBV replication more evidently. Key words：Hepatitis B virus(HBV); Hepatitis C virus(HCV); Co-infection

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