Citation: Yalan Liu, Zhiyuan Zhu, Yuncheng Li, Mengshi Yang, Qinxue Hu. Migrasomes released by HSV-2-infected cells serve as a conveyance for virus spread .VIROLOGICA SINICA, 2023, 38(4) : 643-645.  http://dx.doi.org/10.1016/j.virs.2023.06.001

Migrasomes released by HSV-2-infected cells serve as a conveyance for virus spread

  • Corresponding author: Yalan Liu, liuyl@wh.iov.cn
    Qinxue Hu, qhu@wh.iov.cn
  • Received Date: 07 February 2023
    Accepted Date: 05 June 2023
    Available online: 07 June 2023
  • Highlights
    1. Cells infected with HSV-2 release migrasomes containing HSV-2 virions.
    2. HSV-2 in the isolated migrasomes can be transmitted to uninfected cells and cause productive infection.
    3.It is the first time that migrasomes have been found to play a role in virus spread.

  • 加载中
  • 10.1016j.virs.2023.06.001-ESM.docx
    1. Baeten, J.M., McClelland, R.S., Corey, L., Overbaugh, J., Lavreys, L., Richardson, B.A., Wald, A., Mandaliya, K., Bwayo, J.J., Kreiss, J.K., 2004. Vitamin A supplementation and genital shedding of herpes simplex virus among HIV-1-infected women:a randomized clinical trial. J Infect Dis 189, 1466-1471.

    2. Bassani, S., Cingolani, L.A., 2012. Tetraspanins:Interactions and interplay with integrins. Int J Biochem Cell Biol 44, 703-708.

    3. Freeman, E.E., Weiss, H.A., Glynn, J.R., Cross, P.L., Whitworth, J.A., Hayes, R.J., 2006. Herpes simplex virus 2 infection increases HIV acquisition in men and women:systematic review and meta-analysis of longitudinal studies. AIDS 20, 73-83.

    4. Huang, Y., Zucker, B., Zhang, S., Elias, S., Zhu, Y., Chen, H., Ding, T., Li, Y., Sun, Y., Lou, J., Kozlov, M.M., Yu, L., 2019. Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains. Nat Cell Biol 21, 991-1002.

    5. Jiang, D., Jiang, Z., Lu, D., Wang, X., Liang, H., Zhang, J., Meng, Y., Li, Y., Wu, D., Huang, Y., Chen, Y., Deng, H., Wu, Q., Xiong, J., Meng, A., Yu, L., 2019. Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation. Nat Cell Biol 21, 966-977.

    6. Jiao, H., Jiang, D., Hu, X., Du, W., Ji, L., Yang, Y., Li, X., Sho, T., Wang, X., Li, Y., Wu, Y.T., Wei, Y.H., Hu, X., Yu, L., 2021. Mitocytosis, a migrasome-mediated mitochondrial quality-control process. Cell 184, 2896-2910 e2813.

    7. Kimberlin, D.W., Whitley, R.J., 2007. Antiviral therapy of HSV-1 and -2, in:Arvin, A., Campadelli-Fiume, G., Mocarski, E., Moore, P.S., Roizman, B., Whitley, R., Yamanishi, K. (Eds.), Human Herpesviruses:Biology, Therapy, and Immunoprophylaxis, Cambridge.

    8. Liu, Y., Li, S., Rong, W., Zeng, C., Zhu, X., Chen, Q., Li, L., Liu, Z.H., Zen, K., 2020. Podocyte-Released Migrasomes in Urine Serve as an Indicator for Early Podocyte Injury. Kidney Dis (Basel) 6, 422-433.

    9. Ma, L., Li, Y., Peng, J., Wu, D., Zhao, X., Cui, Y., Chen, L., Yan, X., Du, Y., Yu, L., 2015. Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration. Cell Res 25, 24-38.

    10. Sattentau, Q., 2008. Avoiding the void:cell-to-cell spread of human viruses. Nat Rev Microbiol 6, 815-826.

    11. Zhang, C., Li, T., Yin, S., Gao, M., He, H., Li, Y., Jiang, D., Shi, M., Wang, J., Yu, L., 2022a. Monocytes deposit migrasomes to promote embryonic angiogenesis. Nat Cell Biol 24, 1726-1738.

    12. Zhang, N., Gao, S., Zhang, L., 2022b. Chikungunya virus nsP1 induces migrasome formation. J Infect 85, e158-e161.

    13. Zhang, Y., Wang, J., Ding, Y., Zhang, J., Xu, Y., Xu, J., Zheng, S., Yang, H., 2020. Migrasome and Tetraspanins in Vascular Homeostasis:Concept, Present, and Future. Front Cell Dev Biol 8, 438.

    14. Zhao, X., Lei, Y., Zheng, J., Peng, J., Li, Y., Yu, L., Chen, Y., 2019. Identification of markers for migrasome detection. Cell Discov 5, 27.

    15. Zhu, M., Zou, Q., Huang, R., Li, Y., Xing, X., Fang, J., Ma, L., Li, L., Yang, X., Yu, L., 2021. Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells. Cell Res 31, 237-240.

  • 加载中

Article Metrics

Article views(1593) PDF downloads(11) Cited by()

Related
Proportional views

    Migrasomes released by HSV-2-infected cells serve as a conveyance for virus spread

      Corresponding author: Yalan Liu, liuyl@wh.iov.cn
      Corresponding author: Qinxue Hu, qhu@wh.iov.cn
    • a. State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China;
    • b. Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China;
    • c. Institute for Infection and Immunity, St George's University of London, London, SW17 0RE, UK;
    • d. Hubei Jiangxia Laboratory, Wuhan, 430200, China

    Abstract: Highlights
    1. Cells infected with HSV-2 release migrasomes containing HSV-2 virions.
    2. HSV-2 in the isolated migrasomes can be transmitted to uninfected cells and cause productive infection.
    3.It is the first time that migrasomes have been found to play a role in virus spread.

    Reference (15) Relative (20)

    目录

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return