Mechanisms of HIV envelope-induced T lymphocyte apoptosis

Zhi-Tao WAN; Xu-lin CHEN

doi:10.1007/s12250-010-3148-7

October 2010

Zhi-Tao WAN and Xu-lin CHEN. Mechanisms of HIV envelope-induced T lymphocyte apoptosis[J]. Virologica Sinica, 2010, 25(5): 307-315. doi: 10.1007/s12250-010-3148-7

Citation: Zhi-Tao WAN, Xu-lin CHEN. Mechanisms of HIV envelope-induced T lymphocyte apoptosis .VIROLOGICA SINICA, 2010, 25(5) : 307-315. http://dx.doi.org/10.1007/s12250-010-3148-7

HIV包膜糖蛋白诱导T淋巴细胞凋亡的机制

万志涛 ,
陈绪林 ^,

cstr: 32224.14.s12250-010-3148-7

中国科学院武汉病毒研究所，病毒学国家重点实验室, 湖北武汉 430071

通讯作者： 陈绪林, chenxl@wh.iov.cn
收稿日期： 2010-04-29
录用日期： 2010-06-13

摘要

感染HIV会导致CD4 T淋巴细胞水平的持续下降，引起免疫系统的功能障碍，并最终发展成为艾滋病。在HIV感染过程中造成T细胞丢失的机制比较复杂，被感染细胞以及旁观细胞的凋亡可能在这一过程当中发挥主导作用。HIV的包膜糖蛋白可以通过死亡受体介导的凋亡途径以及线粒体途径诱导细胞凋亡。本文对HIV包膜糖蛋白诱导T淋巴细胞凋亡的机制进行了综述。
- HIV
- , 包膜糖蛋白
- , T细胞
- , 凋亡

Mechanisms of HIV envelope-induced T lymphocyte apoptosis

Zhi-Tao WAN ,
Xu-lin CHEN ^,

State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China

Corresponding author: Xu-lin CHEN, chenxl@wh.iov.cn
Received Date: 29 April 2010
Accepted Date: 13 June 2010

Abstract

Infection by the human immunodeficiency virus (HIV) is characterized by a progressive depletion of CD4 T lymphocytes, which leads to dysfunction of the immune system. Although a variety of mechanisms may contribute to the gradual T cell decline that occurs in HIV-infected patients, abnormal apoptosis of infected or bystander T lymphocytes is an important event leading to immunodeficiency. The HIV envelope glycoprotein plays a crucial role in HIV associated apoptosis through both death receptor-mediated and mitochondria-dependent pathways. This review summarizes current knowledge of Env-mediated T lymphocyte apoptosis.
- HIV
- , Envelope glycoprotein
- , T lymphocyte
- , Apoptosis

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