摘要

关键词：
• SARS-CoV-2
• , iPSC
• , 心脏类器官
• , 心肌损伤

Abstract

References

1. Bailey, A.L., Dmytrenko, O., Greenberg, L., Bredemeyer, A.L., Ma, P., Liu, J., Penna, V., Winkler, E.S., Sviben, S., Brooks, E., Nair, A.P., Heck, K.A., Rali, A.S., Simpson, L., Saririan, M., Hobohm, D., Stump, W.T., Fitzpatrick, J.A., Xie, X., Zhang, X., Shi, P.Y., Hinson, J.T., Gi, W.T., Schmidt, C., Leuschner, F., Lin, C.Y., Diamond, M.S., Greenberg, M.J., Lavine, K.J., 2021. SARS-CoV-2 infects human engineered heart tissues and models COVID-19 myocarditis. JACC Basic Transl Sci 6, 331–345.
   

2. Bearse, M., Hung, Y.P., Krauson, A.J., Bonanno, L., Boyraz, B., Harris, C.K., Helland, T.L., Hilburn, C.F., Hutchison, B., Jobbagy, S., Marshall, M.S., Shepherd, D.J., Villalba, J.A., Delfino, I., Mendez-Pena, J., Chebib, I., Newton-Cheh, C., Stone, J.R., 2021. Factors associated with myocardial SARS-CoV-2 infection, myocarditis, and cardiac inflammation in patients with COVID-19. Mod. Pathol. 34, 1345–1357.
   

3. Bojkova, D., Wagner, J.U.G., Shumliakivska, M., Aslan, G.S., Saleem, U., Hansen, A., Luxán, G., Günther, S., Pham, M.D., Krishnan, J., Harter, P.N., Ermel, U.H., Frangakis, A.S., Milting, H., Zeiher, A.M., Klingel, K., Cinatl, J., Dendorfer, A., Eschenhagen, T., Tschöpe, C., Ciesek, S., Dimmeler, S., 2020. SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes. Cardiovasc. Res. 116, 2207–2215.
   

4. Bräuninger, H., Stoffers, B., Fitzek, A.D.E., Meißner, K., Aleshcheva, G., Schweizer, M., Weimann, J., Rotter, B., Warnke, S., Edler, C., Braun, F., Roedl, K., Scherschel, K., Escher, F., Kluge, S., Huber, T.B., Ondruschka, B., Schultheiss, H.P., Kirchhof, P., Blankenberg, S., Püschel, K., Westermann, D., Lindner, D., 2022. Cardiac SARS-CoV-2 infection is associated with pro-inflammatory transcriptomic alterations within the heart. Cardiovasc. Res. 118, 542–555.
   

5. Clevers, H., 2020. COVID-19: organoids go viral. Nat. Rev. Mol. Cell Biol. 21, 355–356.
   

6. Lewis-Israeli, Y.R., Wasserman, A.H., Gabalski, M.A., Volmert, B.D., Ming, Y., Ball, K.A., Yang, W., Zou, J., Ni, G., Pajares, N., Chatzistavrou, X., Li, W., Zhou, C., Aguirre, A., 2021. Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease. Nat. Commun. 12, 5142.
   

7. Litvinňková, M., Talavera-López, C., Maatz, H., Reichart, D., Worth, C.L., Lindberg, E.L., Kanda, M., Polanski, K., Heinig, M., Lee, M., Nadelmann, E.R., Roberts, K., Tuck, L., Fasouli, E.S., DeLaughter, D.M., McDonough, B., Wakimoto, H., Gorham, J.M., Samari, S., Mahbubani, K.T., Saeb-Parsy, K., Patone, G., Boyle, J.J., Zhang, H.B., Zhang, H., Viveiros, A., Oudit, G.Y., Bayraktar, O.A., Seidman, J.G., Seidman, C.E., Noseda, M., Hubner, N., Teichmann, S.A., 2020. Cells of the adult human heart.Nature 588, 466–472.
   

8. Ma, Q., Ma, W.J., Song, T.Z., Wu, Z.B., Liu, Z.Y., Hu, Z.X., Han, J.B., Xu, L., Zeng, B., Wang, B.S., Sun, Y.N., Yu, D.D., Wu, Q., Yao, Y.G., Zheng, Y.T., Wang, X.Q., 2022.Single-nucleus transcriptomic profiling of multiple organs in a rhesus macaque model of SARS-CoV-2 infection. Zool. Res. 43, 1041–1062.
   

9. Mills, R.J., Humphrey, S.J., Fortuna, P.R.J., Lor, M., Foster, S.R., Quaife-Ryan, G.A., Johnston, R.L., Dumenil, T., Bishop, C., Rudraraju, R., Rawle, D.J., Le, T., Zhao, W., Lee, L., Mackenzie-Kludas, C., Mehdiabadi, N.R., Halliday, C., Gilham, D., Fu, L., Nicholls, S.J., Johansson, J., Sweeney, M., Wong, N.C.W., Kulikowski, E., Sokolowski, K.A., Tse, B.W.C., Devilée, L., Voges, H.K., Reynolds, L.T., Krumeich, S., Mathieson, E., Abu-Bonsrah, D., Karavendzas, K., Griffen, B., Titmarsh, D., Elliott, D.A., McMahon, J., Suhrbier, A., Subbarao, K., Porrello, E.R., Smyth, M.J., Engwerda, C.R., MacDonald, K.P.A., Bald, T., James, D.E., Hudson, J.E., 2021. BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection. Cell 184, 2167–2182.e22.
   

10. Nicin, L., Abplanalp, W.T., Mellentin, H., Kattih, B., Tombor, L., John, D., Schmitto, J.D., Heineke, J., Emrich, F., Arsalan, M., Holubec, T., Walther, T., Zeiher, A.M., Dimmeler, S., 2020. Cell type-specific expression of the putative SARS-CoV-2 receptor ACE2 in human hearts. Eur. Heart J. 41, 1804–1806.
    

11. Patone, M., Mei, X.W., Handunnetthi, L., Dixon, S., Zaccardi, F., Shankar-Hari, M., Watkinson, P., Khunti, K., Harnden, A., Coupland, C.A.C., Channon, K.M., Mills, N.L., Sheikh, A., Hippisley-Cox, J., 2022. Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection. Nat.Med. 28, 410–422.
    

12. Perez-Bermejo, J.A., Kang, S., Rockwood, S.J., Simoneau, C.R., Joy, D.A., Silva, A.C., Ramadoss, G.N., Flanigan, W.R., Fozouni, P., Li, H.H., Chen, P.Y., Nakamura, K., Whitman, J.D., Hanson, P.J., McManus, B.M., Ott, M., Conklin, B.R., McDevitt, T.C., 2021. SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19. Sci. Transl. Med. 13, eabf7872.
    

13. Schurink, B., Roos, E., Radonic, T., Barbe, E., Bouman, C.S.C., de Boer, H.H., de Bree, G.J., Bulle, E.B., Aronica, E.M., Florquin, S., Fronczek, J., Heunks, L.M.A., de Jong, M.D., Guo, L., du Long, R., Lutter, R., Molenaar, P.C.G., Neefjes-Borst, E.A., Niessen, H.W.M., van Noesel, C.J.M., Roelofs, J.J.T.H., Snijder, E.J., Soer, E.C., Verheij, J., Vlaar, A.P.J., Vos, W., van der Wel, N.N., van der Wal, A.C., van der Valk, P., Bugiani, M., 2020. Viral presence and immunopathology in patients with lethal COVID-19: a prospective autopsy cohort study. Lancet. Microbe. 1, e290–e299.
    

14. Varga, Z., Flammer, A.J., Steiger, P., Haberecker, M., Andermatt, R., Zinkernagel, A.S., Mehra, M.R., Schuepbach, R.A., Ruschitzka, F., Moch, H., 2020. Endothelial cell infection and endotheliitis in COVID-19. Lancet 395, 1417–1418.
    

15. Xie, Y., Xu, E., Bowe, B., Al-Aly, Z., 2022. Long-term cardiovascular outcomes of COVID-19. Nat. Med. 28, 583–590.
    

16. Yang, W., Zhang, C., Wu, Y.H., Liu, L.B., Zhen, Z.D., Fan, D.Y., Song, Z.R., Chang, J.T., Wang, P.G., An, J., 2023. Mice 3D testicular organoid system as a novel tool to study Zika virus pathogenesis. Virol. Sin. 38, 66–74.
    

Proportional views

Electronic Supplementary Material

10.1016j.virs.2023.09.005-ESM1.docx
10.1016j.virs.2023.09.005-ESM2.mp4