Diversity analysis of tick-associated viruses in northeast China

Yang Li; Yu Bai; Wenli Liu; Jing Li; Fengjuan Tian; Xiaohu Han; Lei Liu; Yigang Tong

doi:10.1016/j.virs.2023.10.003

December 2023

. doi: 10.1016/j.virs.2023.10.003

Citation: Yang Li, Yu Bai, Wenli Liu, Jing Li, Fengjuan Tian, Xiaohu Han, Lei Liu, Yigang Tong. Diversity analysis of tick-associated viruses in northeast China .VIROLOGICA SINICA, 2023, 38(6) : 961-965. http://dx.doi.org/10.1016/j.virs.2023.10.003

中国东北地区蜱相关病毒多样性分析

李洋 ^a,b ,
白玉 ^a,b ,
刘文丽 ^b,d ,
李景 ^b ,
田凤娟 ^b ,
韩小虎 ^c,, ,
刘蕾 ^a,, ,
童贻刚 ^a,b,,

a. 佳木斯大学基础医学院, 佳木斯, 154007, 中国;
b. 北京化工大学生命科学与技术学院, 北京, 100029, 中国;
c. 沈阳农业大学, 沈阳, 110866, 中国;
d. 北京市科学技术研究院分析测试研究所(北京市理化分析测试中心), 北京, 100094, 中国

通讯作者： 韩小虎, hxh8849@syau.edu.cn; 刘蕾, liuleitianxue@163.com; 童贻刚, tongyigang@mail.buct.edu.cn
收稿日期： 2023-05-13
录用日期： 2023-10-08

摘要

蜱是人畜共患传染病的重要传播媒介，可携带多种病毒，如克里米亚-刚果出血热（CCHFV）、蜱传脑炎（TBEV）、严重发热伴血小板减少综合征（SFTSV）等，这些病毒可导致人类和家畜患有高死亡率的疾病。本研究旨在系统性研究中国东北地区蜱传病毒种类。我们分别从辽宁省和内蒙古自治区的八个地区共采集了533只蜱，并鉴定出Haemaphysalis longicornis、Dermacentor silvarum、Dermacentor nuttalli、Dermacentor niveus、Dermacentor sinicus和Dermacentor marginatus，其中以H.longicornis分布最为广泛。根据下一代测序，蜱携带的病毒属于11个科：分别为：Nairoviridae、Phenuiviridae、Peribunyaviridae、Flaviviridae、Rhabdoviridae、Oorthomyxoviridae、Parvoviridae、Hepeviridae、Dicistroviridae、Totiviridae和未分类病毒科。本研究共鉴定出11种病毒，它们显示出极大的基因组和进化多样性，其中包括三个潜在的新物种（与已知物种核苷酸同源性低于90%），分别与阿龙山病毒（ALSV）、塔城蜱病毒2（TcTV-2）和Thogoto病毒（THOV）有关。这三种蜱传病毒都可能对人类和动物致病，其中塔城蜱病毒2是首次从新疆省以外的地区和不同的蜱种（D.niveus.）中检出。这些结果为蜱传相关病毒提供了有价值的信息，并强调了辽宁省和内蒙古自治区对特定蜱传病毒性疾病进行监测的重要性。
- 蜱传病毒
- , 新发传染病
- , 下一代测序
- , 基因组特征
- , 系统发育分析

Diversity analysis of tick-associated viruses in northeast China

Yang Li ^a,b ,
Yu Bai ^a,b ,
Wenli Liu ^b,d ,
Jing Li ^b ,
Fengjuan Tian ^b ,
Xiaohu Han ^c,, ,
Lei Liu ^a,, ,
Yigang Tong ^a,b,,

a. Jiamusi University School of Basic Medicine, Jiamusi, 154007, China;
b. College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China;
c. Shenyang Agricultural University, Shenyang, 110866, China;
d. Institute of Analysis and Testing, Beijing Academy of Science and Technology (Beijing Center for Physical & Chemical Analysis), Beijing, 100094, China

Corresponding author: Xiaohu Han, hxh8849@syau.edu.cn Lei Liu, liuleitianxue@163.com Yigang Tong, tongyigang@mail.buct.edu.cn
Received Date: 13 May 2023
Accepted Date: 08 October 2023

Abstract

Highlights
1. This study identified eleven tick-borne viruses in Liaoning Province and Inner Mongolia, China, which greatly enrich the diversity of tick-borne virus.
2. Tacheng tick virus 2 is for the first time detected outside Xinjiang and in a novel tick species D. niveus.
3. The Alongshan virus and Tacheng tick virus 2 identified in this study can be considered as novel species.

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