Cross-species transmission and host range genes in poxviruses

Chen-Hui Yang; A-Ling Song; Ye Qiu; Xing-Yi Ge

doi:10.1016/j.virs.2024.01.007

April 2024

. doi: 10.1016/j.virs.2024.01.007

Citation: Chen-Hui Yang, A-Ling Song, Ye Qiu, Xing-Yi Ge. Cross-species transmission and host range genes in poxviruses .VIROLOGICA SINICA, 2024, 39(2) : 177-193. http://dx.doi.org/10.1016/j.virs.2024.01.007

痘病毒的跨物种传播与宿主范围基因

中国湖南省长沙市 410012号湖南大学生物学院, 湖南省医学病毒学重点实验室

通讯作者： 邱烨, qiuye@hnu.edu.cn; 葛行义, xyge@hnu.edu.cn
收稿日期： 2023-06-20
录用日期： 2024-01-18

摘要

由猴痘病毒引起的持续流行的人类猴痘引起公众对猴痘病毒及其他痘病毒的未来传播的关注。猴痘病毒是一种典型的人兽共患病毒，可以感染人类并引起类似天花的症状。猴痘病毒属于痘病毒科，痘病毒科宿主范围较广，从节肢动物到脊椎动物均可感染。不同宿主间痘病毒的跨物种传播经常被报道并引发流行病。痘病毒具有复杂的线性双链DNA基因组，编码数百种蛋白质。与痘病毒宿主范围相关的基因称为宿主范围基因。本综述简要介绍了痘病毒的分类、系统发生和宿主，并全面总结了目前痘病毒跨物种传播的知识。痘病毒的宿主范围基因尤其被重点描述并深入讨论了它们对病毒宿主范围的影响。我们期望这篇综述对痘病毒的跨物种传播以及宿主范围基因目前的研究进展提供一个全面的描述，为学术研究和未来疾病控制提供宝贵的参考。
- 痘病毒宿主范围基因宿主范围跨物种传播

Cross-species transmission and host range genes in poxviruses

College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha, 410012, China

Corresponding author: Ye Qiu, qiuye@hnu.edu.cn Xing-Yi Ge, xyge@hnu.edu.cn
Received Date: 20 June 2023
Accepted Date: 18 January 2024

Abstract

The persistent epidemic of human mpox, caused by mpox virus (MPXV), raises concerns about the future spread of MPXV and other poxviruses. MPXV is a typical zoonotic virus which can infect human and cause smallpox-like symptoms. MPXV belongs to the Poxviridae family, which has a relatively broad host range from arthropods to vertebrates. Cross-species transmission of poxviruses among different hosts has been frequently reported and resulted in numerous epidemics. Poxviruses have a complex linear double-strand DNA genome that encodes hundreds of proteins. Genes related to the host range of poxvirus are called host range genes (HRGs). This review briefly introduces the taxonomy, phylogeny and hosts of poxviruses, and then comprehensively summarizes the current knowledge about the cross-species transmission of poxviruses. In particular, the HRGs of poxvirus are described and their impacts on viral host range are discussed in depth. We hope that this review will provide a comprehensive perspective about the current progress of researches on cross-species transmission and HRG variation of poxviruses, serving as a valuable reference for academic studies and disease control in the future.
- Poxvirus
- , Host range gene (HRG)
- , Host spectrum
- , Cross-species transmission

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