. doi: 10.1016/j.virs.2024.02.004
Citation: Yi Yin, Yi Zhang, Lelin Sun, Shuqiang Wang, Yong Zeng, Bo Gong, Lulin Huang, Yongquan He, Zhenglin Yang. Association analysis of genetic variants in critical patients with COVID-19 and validation in a Chinese population .VIROLOGICA SINICA, 2024, 39(2) : 347-350.  http://dx.doi.org/10.1016/j.virs.2024.02.004

COVID-19危重症患者遗传变异的关联性分析在中国人群中的验证

  • 新型冠状病毒肺炎(COVID-19)于2019年底开始大流行并迅速蔓延,已造成全球数百万人死亡。不同患者对COVID-19的感染严重程度有所不同。基于人群的meta分析有助于理解SARS-CoV-2感染的遗传危险因素与COVID-19严重程度之间的因果关系。为确定影响COVID-19疾病发展的遗传因素,我们在中国人群(n = 632例病例和3021例对照)中进行了全基因组关联研究。在本研究中,我们总结并回顾了世界范围内在22份出版物的COVID-19危重症患者全基因组关联研究中报道的单核苷酸多态性(SNPs),共纳入>167,695例病例和>3,687,897例对照,包括欧洲、美国、南亚、东亚和非洲人群。然后,我们在上述中国COVID-19危重患者人群中验证了这些变异。结果显示,经Bonferroni校正后(P < 0.05/42 = 0.00119),3个基因(DPP9中的rs12610495和靠近 RNU2-47PTYRP1的rs4628342、rs1412074、rs1929456、rs1331346和rs10116714)与中国人群显著相关。此外,在已报道的研究和我们的中国人群数据集中,三个SNPs(即FOXP4的rs1886814、GRM5的rs10831496和OAS1的rs10774671)被精确标记。然而,在合并数据的meta分析中,只有FOXP4中的rs1886814与COVID-19的严重程度相关。综上,我们评估了遗传变异与COVID-19严重程度的相关性,并获得了对中国人群中COVID-19预后的见解。

Association analysis of genetic variants in critical patients with COVID-19 and validation in a Chinese population

  • Highlights
    1. Single-nucleotide polymorphisms in critical patients with COVID-19 conducted worldwide were validated in Chinese population.
    2. Variants in DPP9 and near RNU2-47P and TYRP1 showed the strongest associated signals with COVID-19 severity in Chinese population.
    3. Rs1886814 in FOXP4 was correlated with COVID-19 severity in Chinese and other populations.

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    通讯作者: 陈斌, bchen63@163.com
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      沈阳化工大学材料科学与工程学院 沈阳 110142

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    Association analysis of genetic variants in critical patients with COVID-19 and validation in a Chinese population

      Corresponding author: Lulin Huang, huangluling@yeah.net
      Corresponding author: Yongquan He, yongquanhe2012@163.com
      Corresponding author: Zhenglin Yang, yangzhenglin@cashq.ac.cn
    • a. Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610213, China;
    • b. Sichuan Provincial Key Laboratory for Human Disease Gene Study, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China;
    • c. Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China;
    • d. University of Chinese Academy of Sciences, Beijing, 100049, China;
    • e. Infectious Disease Department, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China;
    • f. Department of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China

    Abstract: Highlights
    1. Single-nucleotide polymorphisms in critical patients with COVID-19 conducted worldwide were validated in Chinese population.
    2. Variants in DPP9 and near RNU2-47P and TYRP1 showed the strongest associated signals with COVID-19 severity in Chinese population.
    3. Rs1886814 in FOXP4 was correlated with COVID-19 severity in Chinese and other populations.

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