Co-circulation of all four DENV serotypes during 2016 outbreak in Sinaloa, Mexico: First report of DENV-4 in patients

Annete Itzel Apodaca-Medina; José Israel Torres-Avendaño; Hipólito Castillo-Ureta; Edith Hilario Torres-Montoya; Sergio Alonso Durán-Pérez; Lorenzo Ulises Osuna-Martínez; María Elena Báez-Flores; José Guadalupe Rendón-Maldonado

doi:10.1016/j.virs.2025.07.010

August 2025

. doi: 10.1016/j.virs.2025.07.010

Citation: Annete Itzel Apodaca-Medina, José Israel Torres-Avendaño, Hipólito Castillo-Ureta, Edith Hilario Torres-Montoya, Sergio Alonso Durán-Pérez, Lorenzo Ulises Osuna-Martínez, María Elena Báez-Flores, José Guadalupe Rendón-Maldonado. Co-circulation of all four DENV serotypes during 2016 outbreak in Sinaloa, Mexico: First report of DENV-4 in patients .VIROLOGICA SINICA, 2025, 40(4) : 680-683. http://dx.doi.org/10.1016/j.virs.2025.07.010

Co-circulation of all four DENV serotypes during 2016 outbreak in Sinaloa, Mexico: First report of DENV-4 in patients

a. Unidad de Investigaciones en Biotecnología Biomédica, Universidad Autónoma de Occidente, Unidad Regional Culiacán, Boulevard Lola Beltrán S/N, 4 de Marzo, C. P. 80054, Culiacán, Sinaloa, Mexico;
b. Posgrado en Ciencias Biológicas, Facultad de Biología, Universidad Autónoma de Sinaloa, Ciudad Universitaria, Boulevard Universitarios S/N, C. P. 80013, Culiacán, Sinaloa, Mexico;
c. Posgrado en Biotecnología, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Sinaloa, Ciudad Universitaria, Boulevard Universitarios S/N, C. P. 80013, Culiacán, Sinaloa, Mexico;
d. Posgrado en Ciencias Biomédicas, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Sinaloa, Ciudad Universitaria, Boulevard Universitarios S/N, C. P. 80013, Culiacán, Sinaloa, Mexico

通讯作者： José Guadalupe Rendón-Maldonado, jgrendonm@uas.edu.mx
收稿日期： 2025-03-01
录用日期： 2025-07-16

摘要

The serotype with the highest incidence during the 2016 dengue outbreak in Sinaloa was DENV-2, followed by DENV-4.
This study represents the first report of the DENV-4 serotype in Sinaloa, Mexico, prior to 2022.
Phylogenetic analysis clustered DENV-2 in Asian II genotype and DENV-4 in genotype I.
- Dengue virus (DENV)
- , serotypes
- , DENV-4
- , Mexico
- , First report

Co-circulation of all four DENV serotypes during 2016 outbreak in Sinaloa, Mexico: First report of DENV-4 in patients

a. Unidad de Investigaciones en Biotecnología Biomédica, Universidad Autónoma de Occidente, Unidad Regional Culiacán, Boulevard Lola Beltrán S/N, 4 de Marzo, C.P. 80054, Culiacán, Sinaloa, Mexico;
b. Posgrado en Ciencias Biológicas, Facultad de Biología, Universidad Autónoma de Sinaloa, Ciudad Universitaria, Boulevard Universitarios S/N, C.P. 80013, Culiacán, Sinaloa, Mexico;
c. Posgrado en Biotecnología, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Sinaloa, Ciudad Universitaria, Boulevard Universitarios S/N, C.P. 80013, Culiacán, Sinaloa, Mexico;
d. Posgrado en Ciencias Biomédicas, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Sinaloa, Ciudad Universitaria, Boulevard Universitarios S/N, C.P. 80013, Culiacán, Sinaloa, Mexico

Corresponding author: José Guadalupe Rendón-Maldonado, jgrendonm@uas.edu.mx
Received Date: 01 March 2025
Accepted Date: 16 July 2025

Abstract

The serotype with the highest incidence during the 2016 dengue outbreak in Sinaloa was DENV-2, followed by DENV-4.
This study represents the first report of the DENV-4 serotype in Sinaloa, Mexico, prior to 2022.
Phylogenetic analysis clustered DENV-2 in Asian II genotype and DENV-4 in genotype I.
- Dengue virus (DENV)
- , serotypes
- , DENV-4
- , Mexico
- , First report

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Electronic Supplementary Material

10.1016j.virs.2025.07.010-ESM.docx