Yang Song, Weiwei Gai, Jiaxin Sun, Xiangyu Lv, Haojie Sang, Shuai Guo, Jingqiang Ren, Jingbo Zhai and Shubo Wen. First identification of Tusavirus in calf intestinal tissue suggests interspecies transmission and genomic variation[J]. Virologica Sinica, 2025, 40(5): 860-862. doi: 10.1016/j.virs.2025.09.006
Citation:
Yang Song, Weiwei Gai, Jiaxin Sun, Xiangyu Lv, Haojie Sang, Shuai Guo, Jingqiang Ren, Jingbo Zhai, Shubo Wen.
First identification of Tusavirus in calf intestinal tissue suggests interspecies transmission and genomic variation .VIROLOGICA SINICA, 2025, 40(5)
: 860-862.
http://dx.doi.org/10.1016/j.virs.2025.09.006
首例犊牛肠道组织中Tusavirus鉴定：基因组变异特征与跨宿主传播
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宋扬
a,b
,
-
盖微微
a
,
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孙佳欣
a
,
-
吕香玉
a
,
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桑浩杰
a
,
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郭帅
d
,
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任静强
c,,
,
-
翟景波
b,,
,
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温树波
a,b,,
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a 内蒙古民族大学动物科技学院, 通辽, 内蒙古;
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b. 内蒙古自治区人畜共患病防控重点实验室, 通辽, 内蒙古;
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c. 温州大学病毒所, 温州, 浙江;
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d. 通辽市动物疾病预防控制中心, 通辽, 内蒙古
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通讯作者：
任静强, rjq207@163.com; 翟景波, jbzhai@imun.edu.cn; 温树波, wen0516@126.com
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收稿日期：
2025-05-20
录用日期：
2025-09-24
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摘要
Tusavirus (TuV)是一种新型的细小病毒，首次在突尼斯被发现，并被认为与人类腹泻相关。最近，TuV首次在中国内蒙古自治区东部一头因腹泻死亡的小牛的肠道组织样本中被检测到。该TuV毒株被命名为NM21C6，并进行了全基因组测序，基因组长度为4424个碱基对。与GenBank中其他TuV毒株比较时，其基因组、NS1、VP1和VP2基因的核苷酸同源性分别为81.4%-98.3%、83.3%-95.7%、82.0%-98.4%和81.7%-98.3%。基于14个TuV毒株和26个Parvoviridae家族其他代表性成员的NS1基因、VP1基因和VP2基因的系统发育分析表明，NM21C6与其他TuV毒株密切相关。氨基酸序列比对分析显示，大多数在其他TuV毒株中发现的保守氨基酸结构域也出现在NM21C6中。然而，我们的TuV毒株在VP1中表现出意外的氨基酸插入和缺失，在VP2中则存在缺失。这些发现有助于更好地理解TuV的流行病学和分子特征。
First identification of Tusavirus in calf intestinal tissue suggests interspecies transmission and genomic variation
-
Yang Song
a,b
,
-
Weiwei Gai
a
,
-
Jiaxin Sun
a
,
-
Xiangyu Lv
a
,
-
Haojie Sang
a
,
-
Shuai Guo
d
,
-
Jingqiang Ren
c,,
,
-
Jingbo Zhai
b,,
,
-
Shubo Wen
a,b,,
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a. College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, 028000, China;
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b. Key Laboratory of Zoonose Prevention and Control, Inner Mongolia Autonomous Region, Tongliao, 028000, China;
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c. Institute of Virology, Wenzhou University, Wenzhou, 325035, China;
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d. Animal Disease Prevention and Control Center of Tongliao, Tongliao, 028000, China
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Corresponding author:
Jingqiang Ren, rjq207@163.com
Jingbo Zhai, jbzhai@imun.edu.cn
Shubo Wen, wen0516@126.com
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Received Date:
20 May 2025
Accepted Date:
24 September 2025
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Abstract
Highlights1. This is the first identification of Tusavirus in calf tissue in China, expanding its host species and geographical range.2. Genomic analysis reveals conservation, with nucleotide insertions in the VP1 gene and deletions in both VP1 and VP2 genes.3. Phylogenetic analysis shows close evolutionary linkage between bovine and ovine TuV strains.
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References
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Davies, H., Dastjerdi, A., Everest, D., Floyd, T., Collins, R., Mcfadzean, H., Reuter, G.,Reichel, R., 2024. Incidental finding of a human-like tusavirus in a lamb with lip lesions and fatal pneumonia. J Gen Virol, 105.
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Phan, T.G., Sdiri-Loulizi, K., Aouni, M., Ambert-Balay, K., Pothier, P., Deng, X.,Delwart, E., 2014. New parvovirus in child with unexplained diarrhea, Tunisia. Emerg Infect Dis, 20, 1911-1913.
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Reuter, G., Pankovics, P., Laszlo, Z., Gaspar, G., Hui, A., Delwart, E.,Boros, A., 2022. Human-stool-associated tusavirus (Parvoviridae) in domestic goats and sheep. Arch Virol, 167, 1307-1310.
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