. doi: 10.1016/j.virs.2026.03.008
Citation: Min Chen, Huichao Chen, Yanling Ma, Manhong Jia, Wenfei Ding. Identification of a novel HIV-1 circulating recombinant form (CRF161_0107) from CRF01_AE-C5 lineage among men who have sex with men in southwestern China .VIROLOGICA SINICA, 2026, 41(2) : 470-473.  http://dx.doi.org/10.1016/j.virs.2026.03.008

在中国西南地区男男性行为者中发现源自CRF01_AE-C5谱系的新型HIV-1流行重组型(CRF161_0107)

  • HIV-1重组可显著提升病毒遗传多样性,并直接改变其关键病毒特性。本研究在中国云南省男男性行为者(MSM)人群中鉴定出一种新型HIV-1流行重组型(CRF),命名为CRF161_0107。近全长基因组分析表明,CRF161_0107来源于CRF01_AE和CRF07_BC的重组。5个断点将其基因组划分为6个子区域:I-CRF01_AE(760-3959)、II-CRF07_BC(3960-6120)、III-CRF01_AE (6121-6347),IV-CRF07_BC (6348-8231),V-CRF01_AE (8232-8484) 及 VI-CRF07_BC (8485-9513)。进化分析提示, CRF161_0107可能于2016年左右出现。值得注意的是,其CRF01_AE片段来源于在中国北方地区流行的CRF01_AE-C5谱系,而CRF07_BC片段则来源于CRF07_BC-N谱系。这是中国西南地区首次报道的来源于CRF01_AE-C5谱系的CRF,提示MSM人群的流动或推动了病毒跨区域传播。研究结果表明,关键人群中不断出现新型HIV-1重组毒株,需要加强分子监测和采取针对性干预措施,以有效防控新型重组毒株的传播。

Identification of a novel HIV-1 circulating recombinant form (CRF161_0107) from CRF01_AE-C5 lineage among men who have sex with men in southwestern China

  • Highlights
    1
    Identification of a novel HIV-1 circulating recombinant form (CRF161_0107) in Chinese men who have sex with men.
    2 CRF161_0107 emerged around 2016, exhibiting unique CRF01_AE-C5 and CRF07_BC-N parental lineages.
    3 This is the first report of a CRF derived from CRF01_AE-C5 in southwestern China, suggesting viral migration.
    4 The finding underscores the ongoing evolution of HIV-1 via recombination in key populations such as MSM.

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    12. Xiao, M., Tang, J., Li, J., Lan, Y., Li, X., Li, L., Huang, H., He, S., Lu, H., He, X., Liu, A. & Xin, R. 2025. A novel HIV-1 circulating recombinant form (CRF168_0107) identified from men who have sex with men in Beijing, China. J Infect, 90, 106368.

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    Identification of a novel HIV-1 circulating recombinant form (CRF161_0107) from CRF01_AE-C5 lineage among men who have sex with men in southwestern China

      Corresponding author: Min Chen, chenminyx@hotmail.com
      Corresponding author: Manhong Jia, jiamanhong@hotmail.com
      Corresponding author: Wenfei Ding, yndwf@163.com
    • a. Yunnan Provincial Key Laboratory of Public Health and Biosafety & Health Laboratory Center, Yunnan Center for Disease Control and Prevention (Yunnan Academy of Preventive Medicine), Kunming 650500, China;
    • b. Yunnan Provincial Key Laboratory of Public Health and Biosafety & Institute for AIDS/STD Control and Prevention, Yunnan Center for Disease Control and Prevention (Yunnan Academy of Preventive Medicine), Kunming 650500, China;
    • c. Yunnan Provincial Key Laboratory of Public Health and Biosafety, Yunnan Center for Disease Control and Prevention (Yunnan Academy of Preventive Medicine), Kunming 650500, China

    Abstract: Highlights
    1
    Identification of a novel HIV-1 circulating recombinant form (CRF161_0107) in Chinese men who have sex with men.
    2 CRF161_0107 emerged around 2016, exhibiting unique CRF01_AE-C5 and CRF07_BC-N parental lineages.
    3 This is the first report of a CRF derived from CRF01_AE-C5 in southwestern China, suggesting viral migration.
    4 The finding underscores the ongoing evolution of HIV-1 via recombination in key populations such as MSM.

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