摘要

关键词：
• 黏膜免疫
• , 纳米颗粒疫苗
• , 肺泡巨噬细胞
• , 抗原呈递
• , 鼻内免疫接种

Abstract

References

1. Aegerter, H., Kulikauskaite, J., Crotta, S., Patel, H., Kelly, G., Hessel, E.M., Mack, M., Beinke, S., Wack, A., 2020. Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection. Nat Immunol 21, 145-157.
   

2. Chen, S., Zhang, X., Yao, Y., Wang, S., Li, K., Zhang, B., Ye, T., Chen, L., Wu, Y., Li, E., Xu, B., Zhang, P., Chuai, X., Ran, Y., Gong, R., Zhang, H., Chiu, S., 2024. Ferritin nanoparticle-based Nipah virus glycoprotein vaccines elicit potent protective immune responses in mice and hamsters. Virol Sin 39, 909-916.
   

3. Cohen, A.A., van Doremalen, N., Greaney, A.J., Andersen, H., Sharma, A., Starr, T.N., Keeffe, J.R., Fan, C., Schulz, J.E., Gnanapragasam, P.N.P., Kakutani, L.M., West, A.P., Jr., Saturday, G., Lee, Y.E., Gao, H., Jette, C.A., Lewis, M.G., Tan, T.K., Townsend, A.R., Bloom, J.D., Munster, V.J., Bjorkman, P.J., 2022. Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models. Science 377, eabq0839.
   

4. Eshaghi, B., Schudel, A., Sadeghi, I., Chen, Z., Lee, A.H., Kanelli, M., Tierney, F., Han, J., Ingalls, B., Francis, D.M., Li, G., von Andrian, U., Langer, R., Jaklenec, A., 2024. The role of engineered materials in mucosal vaccination strategies. Nature Reviews Materials 9, 29-45.
   

5. Hussell, T., Bell, T.J., 2014. Alveolar macrophages: plasticity in a tissue-specific context. Nat Rev Immunol 14, 81-93.
   

6. Kawasaki, T., Ikegawa, M., Yunoki, K., Otani, H., Ori, D., Ishii, K.J., Kuroda, E., Takamura, S., Kitabatake, M., Ito, T., Isotani, A., Kawai, T., 2022. Alveolar macrophages instruct CD8(+) T cell expansion by antigen cross-presentation in lung. Cell Rep 41, 111828.
   

7. Kiyono, H., Ernst, P.B., 2025. Nasal vaccines for respiratory infections. Nature 641, 321-330.
   

8. Ma, X., Zou, F., Yu, F., Li, R., Yuan, Y., Zhang, Y., Zhang, X., Deng, J., Chen, T., Song, Z., Qiao, Y., Zhan, Y., Liu, J., Zhang, J., Zhang, X., Peng, Z., Li, Y., Lin, Y., Liang, L., Wang, G., Chen, Y., Chen, Q., Pan, T., He, X., Zhang, H., 2020. Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses. Immunity 53, 1315-1330 e1319.
   

9. Malainou, C., Abdin, S.M., Lachmann, N., Matt, U., Herold, S., 2023. Alveolar macrophages in tissue homeostasis, inflammation, and infection: evolving concepts of therapeutic targeting. J Clin Invest 133.
   

10. Mettelman, R.C., Allen, E.K., Thomas, P.G., 2022. Mucosal immune responses to infection and vaccination in the respiratory tract. Immunity 55, 749-780.
    

11. Zhang, X., Wu, S., Liu, J., Chen, R., Zhang, Y., Lin, Y., Xi, Z., Deng, J., Pu, Z., Liang, C., Feng, J., Li, R., Lin, K., Zhou, M., Liu, Y., Zhang, X., Liu, B., Zhang, Y., He, X., Zhang, H., 2023. A Mosaic Nanoparticle Vaccine Elicits Potent Mucosal Immune Response with Significant Cross-Protection Activity against Multiple SARS-CoV-2 Sublineages. Adv Sci (Weinh) 10, e2301034.
    

12. Zhang, X., Yuan, Y., Wu, B., Wang, X., Lin, Y., Luo, Y., Li, R., Chen, T., Deng, J., Zhang, X., Zou, F., He, X., Zhang, H., 2021. Improvement of a SARS-CoV-2 vaccine by enhancing the conjugation efficiency of the immunogen to self-assembled nanoparticles. Cell Mol Immunol 18, 2042-2044.
    

Proportional views

Electronic Supplementary Material

10.1016j.virs.2026.08.004-ESM2.xlsx
10.1016j.virs.2026.08.004-ESM1.docx