Comparison of Two Pre-s Proteins in Hepatocytes with HBV Replication Status by in situ HBV DNA Hybridization Assay

ZHANG Yong-Yuan; YAN Pu; WANG You-Kun; Yu-Zhi-Qun; HAO Lian-Jie

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August 1990

ZHANG Yong-Yuan, YAN Pu, WANG You-Kun, Yu-Zhi-Qun and HAO Lian-Jie. Comparison of Two Pre-s Proteins in Hepatocytes with HBV Replication Status by in situ HBV DNA Hybridization Assay[J]. Virologica Sinica, 1990, 5(4).

Citation: ZHANG Yong-Yuan, YAN Pu, WANG You-Kun, Yu-Zhi-Qun, HAO Lian-Jie. Comparison of Two Pre-s Proteins in Hepatocytes with HBV Replication Status by in situ HBV DNA Hybridization Assay .VIROLOGICA SINICA, 1990, 5(4) : 435.

两种前S蛋白与HBV复制关系的初步研究

1.
同济医科大学同济医院临床免疫研究室
2.
同济医科大学同济医院临床免疫研究室武汉

摘要

乙型肝炎病毒(HBV)前S基因及其产物的发现有助于认识HBV复制规律。一些研究提示:前S_1蛋白是完整病毒颗粒表面的必要成分,其存在与HBV复制密切相关,前S_1检测能敏感和特异地反映HBV复制状态。另一些研究则认为:前S_2蛋白含有人多聚白蛋白的结合位点,并提出前S_2蛋白为HBV复制的新标志。为探讨HBV复制与两种前S蛋白之间的联系,本研究应用原位分子杂交分析一组慢性肝炎患者肝细胞内HBV DNA,同时检测肝细胞内HBsAg、HBcAg与两种前S蛋白,综合分析两种前S蛋白在HBV复制中的地位和作用。
- 前S基因
- , 前S蛋白
- , HBV复制
- , HBV标记
- , 原位杂交

Comparison of Two Pre-s Proteins in Hepatocytes with HBV Replication Status by in situ HBV DNA Hybridization Assay

1.
Clinical Immunology Research Unit
2.
Tongji Hospital

Abstract

To compare relationship between two pre-s proteins and HBV replication HBV DNA in situ hybridization was applied to a group of patients with chronic hepatitis by bio-probe, in conjunction of detection of intrahepatic HBsAg, HBcAg, pre-s1 and pre-s2 antigens. It was found that the positive rate for pre-s1 was up to 75%(15/20), being significantly higher than that of pre-s2 (35%) in the same group. More importantly the presence of pre..sl, rather than pre-s2, was in parallel with the presence of intrahepatic ...
- Pre-s gene
- , Pre-s proteins
- , HBV replication
- , HBV markers
- , In situ hybridization

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Comparison of Two Pre-s Proteins in Hepatocytes with HBV Replication Status by in situ HBV DNA Hybridization Assay

1. Clinical Immunology Research Unit
2. Tongji Hospital

Abstract: To compare relationship between two pre-s proteins and HBV replication HBV DNA in situ hybridization was applied to a group of patients with chronic hepatitis by bio-probe, in conjunction of detection of intrahepatic HBsAg, HBcAg, pre-s1 and pre-s2 antigens. It was found that the positive rate for pre-s1 was up to 75%(15/20), being significantly higher than that of pre-s2 (35%) in the same group. More importantly the presence of pre..sl, rather than pre-s2, was in parallel with the presence of intrahepatic ...