Activity Comparison and Mechanism of Two Promoters of Bovine Foamy Virus

CHEN Jiong; CHENG Ye; CHEN Jian-Beng

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April 2000

CHEN Jiong, CHENG Ye and CHEN Jian-Beng. Activity Comparison and Mechanism of Two Promoters of Bovine Foamy Virus[J]. Virologica Sinica, 2000, 15(2): 93-096.

Citation: CHEN Jiong, CHENG Ye, CHEN Jian-Beng. Activity Comparison and Mechanism of Two Promoters of Bovine Foamy Virus .VIROLOGICA SINICA, 2000, 15(2) : 93-096.

小麦黄花叶病毒和小麦梭条斑花叶病毒的生物学和分子生物学研究

1.
南开大学生命科学学院，天津30007

摘要

线状土传小麦花叶病毒病在欧洲、亚洲和北美洲等地均有发生。这类病毒由根肿菌纲的禾谷多粘菌(Ｐｏｌｙｍｙｘａｇｒａｍｉｎｉｓ)传播,并归类于马铃薯Ｙ病毒科(Ｐｏｔｙｖｉｒｉｄａｅ)的大麦黄花叶病毒属(Ｂｙｍｏｖｉｒｕｓ)。日本的Ｓａｗａｄａ(1927)[1]首次发现并描...
- 小麦黄花叶病毒
- , 小麦梭条斑花叶病毒
- , 流行病学
- , 基因组结构

Activity Comparison and Mechanism of Two Promoters of Bovine Foamy Virus

1.
College of life

Abstract

Abstract：Two promoters．LTR (1ong terminal repeat)and IP (internal promoter)，exist in genomes of foamy viruses．Ge1l transfection and transient expression assay demonstrated that!the basal activity of BFV (bovine foamy virus)IP is much higher than that of BFV LTR；transacti． vator of BF 一Borf-1，which activates gene expression directed by BFV LTR，aLso hmctions on BFV IP with an activation foId higher than tha t on LTR ．The results suggest that BFv IP and LTR may regulate viral gene expression by difierent mechan isms，and that Bod-1 ma y stimulate BFV IP and LTR in diferent ways．In addition．an in vivo DNA compe tition assay demonstrat ed that a comm on transcxiption factor may be involved in both mechanisms of the two promoters ．
- Bovine foam y virus
- , Long terminal repeat
- , Internal promoter

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Activity Comparison and Mechanism of Two Promoters of Bovine Foamy Virus

1. College of life

Abstract: Abstract：Two promoters．LTR (1ong terminal repeat)and IP (internal promoter)，exist in genomes of foamy viruses．Ge1l transfection and transient expression assay demonstrated that!the basal activity of BFV (bovine foamy virus)IP is much higher than that of BFV LTR；transacti． vator of BF 一Borf-1，which activates gene expression directed by BFV LTR，aLso hmctions on BFV IP with an activation foId higher than tha t on LTR ．The results suggest that BFv IP and LTR may regulate viral gene expression by difierent mechan isms，and that Bod-1 ma y stimulate BFV IP and LTR in diferent ways．In addition．an in vivo DNA compe tition assay demonstrat ed that a comm on transcxiption factor may be involved in both mechanisms of the two promoters ．