Partial sequence com parison of three sporadic hepatitis E variants

YANG Jun; ZHANG Hua-Yuan; WANG You-Chun; MAO Qun-Ying; LI He-Min

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June 2000

YANG Jun, ZHANG Hua-Yuan, WANG You-Chun, MAO Qun-Ying and LI He-Min. Partial sequence com parison of three sporadic hepatitis E variants[J]. Virologica Sinica, 2000, 15(3): 232-236.

Citation: YANG Jun, ZHANG Hua-Yuan, WANG You-Chun, MAO Qun-Ying, LI He-Min. Partial sequence com parison of three sporadic hepatitis E variants .VIROLOGICA SINICA, 2000, 15(3) : 232-236.

三株散发性戊型肝炎病毒变异株的部分序列比较

1.
中国药品生物制品检定所，北京100050

摘要

对三株散发性戊型肝炎病毒Ch T11、Ch T2 1、Ch T4 0的部分基因组做克隆测序 ,经比较发现与其它国内外HEV株ORF2部分相应核苷酸序列同源性在 78.3 81.3% ,Ch T2 1与Ch T4 0的核苷酸同源性为 98.8% ,而Ch T11与前两者的同源性则分别为 89.8%和 90 .2 %。Ch T11、Ch T2 1、Ch T4 0与其它HEV株相应氨基酸序列同源性在 95.8 97.9% ,它们之间的氨基酸同源性则为 10 0 %。系统进化树分析显示 ,这三株HEV可能代表着一新型HEV。
- 戊型肝炎病毒
- , 核苷酸同源性
- , 进化树

Partial sequence com parison of three sporadic hepatitis E variants

1.
National Institute for the Control of Pharmaceutical and Biological Products,Beijing 100050，China

Abstract

Partial genomes of three strains of sporadic hepatitis E virus (Ch T11,Ch T21,Ch T40) were cloned and sequenced. The nucleotide and putative amino acid homology of Ch T11,Ch T21,Ch T40 and other HEV strains were 78.3 81.3% and 95.8 97.9%, respectively. The nucleotide homology between Ch T21 and Ch T40 was 98.8%, while the nucleotide homology of Ch T11 and Ch T21,Ch T40 was 89.8% and 90.2%, respectively. The amino acid homology among Ch T11,Ch T21 and Ch T40 was 100%. Phylogenetic analysis suggested that Ch T11, Ch T21 and Ch T40 may represent a new genotype of HEV.
- Hepatitis E virus
- , Nucleotide homology
- , Phylogenetic tree

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Partial sequence com parison of three sporadic hepatitis E variants

1. National Institute for the Control of Pharmaceutical and Biological Products,Beijing 100050，China

Abstract: Partial genomes of three strains of sporadic hepatitis E virus (Ch T11,Ch T21,Ch T40) were cloned and sequenced. The nucleotide and putative amino acid homology of Ch T11,Ch T21,Ch T40 and other HEV strains were 78.3 81.3% and 95.8 97.9%, respectively. The nucleotide homology between Ch T21 and Ch T40 was 98.8%, while the nucleotide homology of Ch T11 and Ch T21,Ch T40 was 89.8% and 90.2%, respectively. The amino acid homology among Ch T11,Ch T21 and Ch T40 was 100%. Phylogenetic analysis suggested that Ch T11, Ch T21 and Ch T40 may represent a new genotype of HEV.