Study of Rheum officinale Against Coxsackievirus B3 in vivo

SHEN Yuan—ying; YANG Zhanqiu; LIU Jian．iun ． al

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February 2001

SHEN Yuan—ying, YANG Zhanqiu, LIU Jian．iun ． al, Study of Rheum officinale Against Coxsackievirus B3 in vivo[J]. Virologica Sinica, 2001, 16(1): 85-87.

Citation: SHEN Yuan—ying, YANG Zhanqiu, LIU Jian．iun ． al, . Study of Rheum officinale Against Coxsackievirus B3 in vivo .VIROLOGICA SINICA, 2001, 16(1) : 85-87.

大黄在体内抗柯萨奇病毒B3的实验研究

1.
云南太理医学院微生物教研室．云南大理671000
2.
武汉大学医学院病毒研究所，湖北武汉430071： 3 武汉大学医学院附属第二临床医院病理科，湖北武汉430071

摘要

In order to search a effective therapy for viral myocardifis，antivial activity of Rheum offici— hale on Coxsackieivirus B3(CVB3)was evaluated in BALB／C mice．After being determined optium scheme with orthogonal design，mice infected with CVB3 were treated with Rheum officinale．rib— avirin and 0．9％ NaC1 The survival rates of the mice were 35％，5％ and 5％；M ed Jan survival time were 23．11 and 10．5 days；Infectious viml titers repecfively，The lesions of cardiac tissues lightened were 10一，10一 ’and 10一 ’TCID50／0．1 mL inmicetreated withRheum offinicale．These re— suits showed that Rheum officinale was effective in treatment of CVB3 infected mice The study pro— vided scientific basis for further research and widen antiviral spectrum of Rheum officinale
- Rheum officinale
- , Coxsaekievirus B3
- , Viral myocarditis
- , BALB／C mice

Study of Rheum officinale Against Coxsackievirus B3 in vivo

1.
I Dep：lrtmerit ofMA’robiology．DaLi Medical college．Dali 671000，China

Abstract

In order to search a effective therapy for viral myocardifis，antivial activity of Rheum offici— hale on Coxsackieivirus B3(CVB3)was evaluated in BALB／C mice．After being determined optium scheme with orthogonal design，mice infected with CVB3 were treated with Rheum officinale．rib— avirin and 0．9％ NaC1 The survival rates of the mice were 35％，5％ and 5％；M ed Jan survival time were 23．11 and 10．5 days；Infectious viml titers repecfively，The lesions of cardiac tissues lightened were 10一，10一 ’and 10一 ’TCID50／0．1 mL inmicetreated withRheum offinicale．These re— suits showed that Rheum officinale was effective in treatment of CVB3 infected mice The study pro— vided scientific basis for further research and widen antiviral spectrum of Rheum officinale
- Rheum officinale
- , Coxsaekievirus B3
- , Viral myocarditis
- , BALB／C mice

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

Study of Rheum officinale Against Coxsackievirus B3 in vivo

1. I Dep：lrtmerit ofMA’robiology．DaLi Medical college．Dali 671000，China

Abstract: In order to search a effective therapy for viral myocardifis，antivial activity of Rheum offici— hale on Coxsackieivirus B3(CVB3)was evaluated in BALB／C mice．After being determined optium scheme with orthogonal design，mice infected with CVB3 were treated with Rheum officinale．rib— avirin and 0．9％ NaC1 The survival rates of the mice were 35％，5％ and 5％；M ed Jan survival time were 23．11 and 10．5 days；Infectious viml titers repecfively，The lesions of cardiac tissues lightened were 10一，10一 ’and 10一 ’TCID50／0．1 mL inmicetreated withRheum offinicale．These re— suits showed that Rheum officinale was effective in treatment of CVB3 infected mice The study pro— vided scientific basis for further research and widen antiviral spectrum of Rheum officinale