Study Oil S Gene Nucleotide Sequence of Hantan SEO Type Virus in China

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June 2001

Study Oil S Gene Nucleotide Sequence of Hantan SEO Type Virus in China[J]. Virologica Sinica, 2001, 16(3): 202-207.

Citation: . Study Oil S Gene Nucleotide Sequence of Hantan SEO Type Virus in China .VIROLOGICA SINICA, 2001, 16(3) : 202-207.

我国SEO型汉坦病毒全S基因核苷酸序列测定

1.
1河北省保定市传染病医院，河北保定0710G0
2.
北省保定市急救巾心．河北保定071000 3巾国预防医学科学院病毒学研究所，北京10220

摘要

为获得SEO型病毒基因组更为详尽的资料，也为局部暴发的原因提供科学的资料，我们采用病毒分离、McA1)s 分型．RT-PCR扩增及核苷酸序列测定的方法，在国内首次测出我国SEO型病毒较为完整的垒S片段，并与76．118、 Seoul、SRII株的核苷酸及氨基酸同源性进行比较．分别为：64．2％、91．8％、96．8％及80 5％、95 4％、97．3％。表明病毒基因组间的重排不是造成发病高峰的原因。
- 肾综合征出血热
- , 汉坦病毒
- , 核苷酸序列

Study Oil S Gene Nucleotide Sequence of Hantan SEO Type Virus in China

1.
1河北省保定市传染病医院，河北保定0710G0
2.
北省保定市急救巾心．河北保定071000 3巾国预防医学科学院病毒学研究所，北京10220

Abstract

Epidemiologic feature of Hemorrhagic fever with renal syndrome(HFRS)is endemic outbrak by SEO type nowadays.This article is to study SEO viral genes and the cause of endemic outbreak of HFRS.Virus isolation,McAbs typing and TR-PCR were used to determine a SEO strain isolated from Hebei province in 1996.Nucleotide sequence of S gene was detected.Compared with 75-118.Seoul and SRll strains,the homologies of nucleotide sequence were 64.2%,91.8%,96.8%,respectively,amino acid sequence were 80.5%,95.4%,97.3%,repectively.The high epidemics of HFRS wasnt because of recombinant of viral genes.This study provides important material for the cause of HFRS outbreak.
- Hemorrhagic feverwith renal syndrome(IIFRS)
- , Hantan Virus
- , Nucleotide sequence

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Study Oil S Gene Nucleotide Sequence of Hantan SEO Type Virus in China

1. 1河北省保定市传染病医院，河北保定0710G0
2. 北省保定市急救巾心．河北保定071000 3巾国预防医学科学院病毒学研究所，北京10220

Abstract: Epidemiologic feature of Hemorrhagic fever with renal syndrome(HFRS)is endemic outbrak by SEO type nowadays.This article is to study SEO viral genes and the cause of endemic outbreak of HFRS.Virus isolation,McAbs typing and TR-PCR were used to determine a SEO strain isolated from Hebei province in 1996.Nucleotide sequence of S gene was detected.Compared with 75-118.Seoul and SRll strains,the homologies of nucleotide sequence were 64.2%,91.8%,96.8%,respectively,amino acid sequence were 80.5%,95.4%,97.3%,repectively.The high epidemics of HFRS wasnt because of recombinant of viral genes.This study provides important material for the cause of HFRS outbreak.