LI Yong, YANG ZI, LIU Jian-jun, GUO Guang-shong, XIAO Hong and WEN Li. L6565 M ouse Leukemia Induced by L6565 Murine Leukemi a Virus[J]. Virologica Sinica, 2001, 16(3): 261-264.
Citation: LI Yong, YANG ZI, LIU Jian-jun, GUO Guang-shong, XIAO Hong, WEN Li. L6565 M ouse Leukemia Induced by L6565 Murine Leukemi a Virus .VIROLOGICA SINICA, 2001, 16(3) : 261-264.

L6565小鼠白血病病毒诱发小鼠白血病

  • 为探讨病毒与白血病发生的关系,我们用Ih565小鼠白血病病毒(IJ5565 MLv)悬液感染乳鼠,每周观察小鼠的 发病情况及病理变化,并用逆转录一聚合酶链反应(RT-PCR)动态检测小鼠体内病毒核酸的分布。结果发现:小鼠 感染病毒后3—5周,其脾脏和淋巴结呈早期白血病的病理改变。至第l0一l2周小鼠发生淋巴细胞白血病.表现出 耸毛、活动减少、腹膨胀等症状。病毒核酸于感染后第2周首先在小鼠胸腺、脾脏检测到,随时间延长,病毒核酸广 泛分布在外周血、胸腺、脾脏、淋巴结等多种脏器组织中。本实验表明I~565小鼠白血病病毒可诱发小鼠白血病,其 机制可能与病毒促使淋巴细胞向白血病细胞转化有关。

L6565 M ouse Leukemia Induced by L6565 Murine Leukemi a Virus

  • Suckling mice were inoculated with L6565 blLV for researehlng the pathogeny of L6565 moL!se Leukemia Afterinoeulatica~,叽emol3y,eⅧ sacrificed r3r week.Theperipheral blood,thymus,[ymp畸node, spleen and liver weTe removed from l’lflOIl~.|I11e tissues were used to observe tIl0 pathological changes and to detect1.6565 MLV RNA by RT-PC~ .At 3~5 weeks postinoeulation.routine thynms.1ymphy node began to swell,And IIIOU~ leukemia was indueed at 10~12 weeks postinoeulatlon.L6565 MLV RNA Ⅵ∞ detected first inⅡl0use thymus and s een at the se~nd week曲er inoculadon,and the viral RNA *,vaS detected in rnanv /131iillle oigalls 8s time goes on.The results sh㈣d that L6565 l/lOUSe leukemia COIlld be jnduced by L6565 naalne leukemia、TirllS,and it is related to the transformation of lvmph0cyte by 1.6565 MLV.

  • 加载中
  • 加载中

Article Metrics

Article views(4403) PDF downloads(883) Cited by(0)

Related
Proportional views
    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    L6565 M ouse Leukemia Induced by L6565 Murine Leukemi a Virus

    • 1. I贵阳医学院免疫学教研室.贵州贵阳550004~ 2.武汉大学医学院病毒学研究所.湖北武汉43007 3武汉太学中南医院病理科,湖北武汉430071

    Abstract: Suckling mice were inoculated with L6565 blLV for researehlng the pathogeny of L6565 moL!se Leukemia Afterinoeulatica~,叽emol3y,eⅧ sacrificed r3r week.Theperipheral blood,thymus,[ymp畸node, spleen and liver weTe removed from l’lflOIl~.|I11e tissues were used to observe tIl0 pathological changes and to detect1.6565 MLV RNA by RT-PC~ .At 3~5 weeks postinoeulation.routine thynms.1ymphy node began to swell,And IIIOU~ leukemia was indueed at 10~12 weeks postinoeulatlon.L6565 MLV RNA Ⅵ∞ detected first inⅡl0use thymus and s een at the se~nd week曲er inoculadon,and the viral RNA *,vaS detected in rnanv /131iillle oigalls 8s time goes on.The results sh㈣d that L6565 l/lOUSe leukemia COIlld be jnduced by L6565 naalne leukemia、TirllS,and it is related to the transformation of lvmph0cyte by 1.6565 MLV.

    Relative (20)

    目录

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return