The Relationships of Serotypes and Nucleotide Sequences 0f The Dengue viruses Genome

SONG Hong; FU Shi—hong; W ANG Huan—Yu; LIANG Guo—dong

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August 2002

SONG Hong, FU Shi—hong, W ANG Huan—Yu and LIANG Guo—dong. The Relationships of Serotypes and Nucleotide Sequences 0f The Dengue viruses Genome[J]. Virologica Sinica, 2002, 17(4): 297-303.

Citation: SONG Hong, FU Shi—hong, W ANG Huan—Yu, LIANG Guo—dong. The Relationships of Serotypes and Nucleotide Sequences 0f The Dengue viruses Genome .VIROLOGICA SINICA, 2002, 17(4) : 297-303.

登革病毒基因组核苷酸序列与血清学分型的相关性研究

1.
中国预防医学科学院病毒学研究所病毒基因212程国家重点实验室，北京100052

摘要

为证明登革病毒基因组核苷酸序列与病毒血清学分型的相关性，本文以病毒全基因组和病毒5 末端非编码区．E蛋白．NS1蛋白和3 末端非编码区四个基因区段分别进行病毒型间比较。比较结果表明病毒全基因组和病毒的各个基因区段均明显分为相互独立的4个分支，与病毒血清型分型完全吻合，不存在型间重组的现象。文章进一步分析了各型登革病毒型内核酸序列的相似性和型内病毒重组的可能性。
- 登革病毒
- , 基因组核苷酸序列
- , 血清学分型

The Relationships of Serotypes and Nucleotide Sequences 0f The Dengue viruses Genome

1.
Institute of Virology，Chinese Academy of Preventive Medicine，Beijing 100052，China

Abstract

The aim of this study was to prove the relationships of serotypes and nucleotide sequences of the Dengue viruses genome．To this end，the nucleotide sequences of 5 noncoding region，3 一noncod— ing region，envelope E glycoprotein，nonstructural protein NS1 were aligned correspondingly．W ith four Dengue viruses phylogenetic groups which were correspo nding to four serotypes each other being identified，Our results demonstrate that there were no intergenomic recombination observed．The po s— sibility of intragenomic recombination and the similarity of nucleotide sequences of different Dengue viruses were analysed．
- Dengue virus
- , Nucleotide sequences of the genome
- , Serotype

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

The Relationships of Serotypes and Nucleotide Sequences 0f The Dengue viruses Genome

1. Institute of Virology，Chinese Academy of Preventive Medicine，Beijing 100052，China

Abstract: The aim of this study was to prove the relationships of serotypes and nucleotide sequences of the Dengue viruses genome．To this end，the nucleotide sequences of 5 noncoding region，3 一noncod— ing region，envelope E glycoprotein，nonstructural protein NS1 were aligned correspondingly．W ith four Dengue viruses phylogenetic groups which were correspo nding to four serotypes each other being identified，Our results demonstrate that there were no intergenomic recombination observed．The po s— sibility of intragenomic recombination and the similarity of nucleotide sequences of different Dengue viruses were analysed．