Citation: Zhuang Wang, Shaokang Yang, Qingsong Dai, Xiaojia Guo, Yuexiang Li, Wei Li, Xiaotong Yang, Jingjing Yang, Xintong Yan, Huimin Tao, Chongda Luo, Song Li, Xingjuan Chen, Ruiyuan Cao, Wu Zhong. In vitro and in vivo efficacy of Molnupiravir against Zika virus infections .VIROLOGICA SINICA, 2023, 38(4) : 639-642.  http://dx.doi.org/10.1016/j.virs.2023.05.011

In vitro and in vivo efficacy of Molnupiravir against Zika virus infections

  • Highlights
    1. Molnupiravir exhibits effective antiviral activity against ZIKV in vitro.
    2. Intraperitoneal administration of Molnupiravir protects mice from lethal ZIKV challenge.
    3. Molnupiravir might act on the replication phase of the ZIKV life cycle.

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  • 10.1016j.virs.2023.05.011-ESM.docx
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    In vitro and in vivo efficacy of Molnupiravir against Zika virus infections

      Corresponding author: Xingjuan Chen, xjchen@nwpu.edu.cn
      Corresponding author: Ruiyuan Cao, 21cc@163.com
      Corresponding author: Wu Zhong, zhongwu@bmi.ac.cn
    • a. Institute of Medical Research, Northwestern Polytechnical University, Xi'an, 710072, China;
    • b. National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China;
    • c. College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018, China;
    • d. Song Li's Academician Workstation of Hainan University (School of Pharmaceutical Sciences), Yazhou Bay, Sanya, 572000, China;
    • e. School of Medicine, Tsinghua University, Beijing, 100084, China

    Abstract: Highlights
    1. Molnupiravir exhibits effective antiviral activity against ZIKV in vitro.
    2. Intraperitoneal administration of Molnupiravir protects mice from lethal ZIKV challenge.
    3. Molnupiravir might act on the replication phase of the ZIKV life cycle.

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