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Volume 37 Issue 2
April 2022

    Cui-hong An, Juan Li, Yi-ting Wang, Shou-min Nie, Wen-hui Chang, Hong Zhou, Lin Xu, Yang-xin Sun, Wei-feng Shi and Ci-xiu Li. Identification of a novel hepacivirus in Mongolian gerbil (Meriones unguiculatus) from Shaanxi, China[J]. Virologica Sinica, 2022, 37(2): 307-310. doi: 10.1016/j.virs.2022.01.016
    Citation: Cui-hong An, Juan Li, Yi-ting Wang, Shou-min Nie, Wen-hui Chang, Hong Zhou, Lin Xu, Yang-xin Sun, Wei-feng Shi, Ci-xiu Li. Identification of a novel hepacivirus in Mongolian gerbil (Meriones unguiculatus) from Shaanxi, China .VIROLOGICA SINICA, 2022, 37(2) : 307-310.  http://dx.doi.org/10.1016/j.virs.2022.01.016
    shu

    一株新型长爪沙鼠丙型肝炎病毒的鉴定

    • a 陕西省疾病预防控制中心, 西安 710054

    • b 山东第一医科大学, 新发传染病病因流行病学重点实验室, 泰安 271000

    • c 山东第一医科大学, 基础医学院, 病原生物学系, 泰安 271000

    • d 山东第一医科大学, 公共卫生学院, 泰安 271000

    • 丙型肝炎病毒属的成员在大量的宿主中发现。长爪沙鼠（Meriones unguiculatus）是鼠科的小型啮齿动物，广泛分布于中国北方、蒙古和俄罗斯的荒漠草原地区。迄今为止，野生长爪沙鼠中丙型肝炎病毒的报道甚少。利用宏转录组测序技术，在陕西省定边县的长爪沙鼠中发现了一种新的丙型肝炎病毒，命名为Gerbil heapcivirus （GeHV）。该病毒接近全长基因组为9107nt，具有典型的丙型肝炎病毒基因组结构：一条编码长度为2826氨基酸多聚蛋白的正链RNA基因组，其中包含10个预测基因。GeHV的多聚蛋白与之前报道的一株啮齿类丙型肝炎病毒的氨基酸同源性最高，为64.01%。基于NS3和NS5B氨基酸序列的系统发育分析显示，GeHV与丙型肝炎病毒E和F关系最为密切。总之，我们证明了一株新型长爪沙鼠丙型肝炎病毒的存在，强调了丙型肝炎病毒在啮齿类动物中的多样性及其增加的宿主范围。

    Identification of a novel hepacivirus in Mongolian gerbil (Meriones unguiculatus) from Shaanxi, China

    • a Department of Plague and Brucellosis, Shaanxi Center for Disease Control and Prevention, Xi' An 710054, China

    • b Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China

    • c Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, China

    • d Department of Pathogen Biology, School of Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, China

    • Highlights:
      1. The first hepacivirus detected in Mongolian gerbils from a plague zones in China.
      2. A novel hepacivirus closely related to hepacivirus E and F.
      3. Mongolian gerbils could be a potential animal model for hepacivirus pathogenicity.
      4. Extending the genetic diversity and host range of hepaciviruses.
    • 加载中

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    • 加载中

    • Electronic Supplementary Material

      10.1016j.virs.2022.01.016-ESM.docx
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      Identification of a novel hepacivirus in Mongolian gerbil (Meriones unguiculatus) from Shaanxi, China

        Corresponding author: Yang-xin Sun, sxpco@126.com
        Corresponding author: Wei-feng Shi, shiwf@ioz.ac.cn
        Corresponding author: Ci-xiu Li, licixiu@sdfmu.edu.cn
      • a Department of Plague and Brucellosis, Shaanxi Center for Disease Control and Prevention, Xi' An 710054, China
      • b Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China
      • c Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, China
      • d Department of Pathogen Biology, School of Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, China
      • Received Date: 28 July 2021
      • Accepted Date: 10 October 2021

      Abstract: Highlights:
      1. The first hepacivirus detected in Mongolian gerbils from a plague zones in China.
      2. A novel hepacivirus closely related to hepacivirus E and F.
      3. Mongolian gerbils could be a potential animal model for hepacivirus pathogenicity.
      4. Extending the genetic diversity and host range of hepaciviruses.

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