Shuaiyong Wang, Manzhu Wang, Lingxue Yu, Juan Wang, Jiecong Yan, Xinli Rong, Yanjun Zhou, Tongling Shan, Wu Tong, Guoxin Li, Hao Zheng, Guangzhi Tong and Hai Yu. Genetic characterization and pathogenicity of a reassortant Eurasian avian-like H1N1 swine influenza virus containing an internal gene cassette from 2009 pandemic H1N1 virus[J]. Virologica Sinica, 2022, 37(4): 627-630. doi: 10.1016/j.virs.2022.04.009
Citation: Shuaiyong Wang, Manzhu Wang, Lingxue Yu, Juan Wang, Jiecong Yan, Xinli Rong, Yanjun Zhou, Tongling Shan, Wu Tong, Guoxin Li, Hao Zheng, Guangzhi Tong, Hai Yu. Genetic characterization and pathogenicity of a reassortant Eurasian avian-like H1N1 swine influenza virus containing an internal gene cassette from 2009 pandemic H1N1 virus .VIROLOGICA SINICA, 2022, 37(4) : 627-630.  http://dx.doi.org/10.1016/j.virs.2022.04.009

一株内部基因盒来源于pdm/09的重组欧亚类禽H1N1亚型猪流感病毒的遗传变异特性及致病性研究

  • 通讯作者: 于海, haiyu_008@126.com
  • 收稿日期: 2021-10-12
    录用日期: 2022-04-11
  • 全基因组同源性分析表明,SC20-01与德国分离株Bremerhaven-17(MN901451)之间的氨基酸同源性大于99%。通过易感动物回归实验,我们首次发现SC20-01可以在兔的生殖系统中高效复制。此外在当地的商品化兔精液中,GI.2兔瘟病毒的检出率高达70%。以上数据表明,我国GI.2兔瘟病毒可能是由于通过精液从欧洲传入。

Genetic characterization and pathogenicity of a reassortant Eurasian avian-like H1N1 swine influenza virus containing an internal gene cassette from 2009 pandemic H1N1 virus

  • Corresponding author: Hai Yu, haiyu_008@126.com
  • Received Date: 12 October 2021
    Accepted Date: 11 April 2022
  • Highlights
    1. Identification of a reassortant EA H1N1 SIV (SD/18) which isolated from a pig farm in Shandong, north China.
    2. Phylogenetic analysis showed that SD/18 virus containing a complete internal gene cassette from pdm/09 virus.
    3. The results of pathogenicity in mice showed that the mortality rate of SD/18 virus in mice could reach 100%.
    4. The potential risk of EA lineage SIVs to humans is very high and we need to pay enough attention to the different reassortant EA H1N1 viruses.

  • 加载中
    1. Brown, I.H., 2000. The epidemiology and evolution of influenza viruses in pigs. Vet. Microbiol. 74, 29–46.

    2. Kothalawala, H., Toussaint, M.J., Gruys, E., 2006. An overview of swine influenza. Vet. Q. 28, 46–53.

    3. Kyriakis, C.S., Zhang, M., Wolf, S., Jones, L.P., Shim, B.S., Chocallo, A.H., Hanson, J.M., Jia, M., Liu, D., Tripp, R.A., 2017. Molecular epidemiology of swine influenza A viruses in the Southeastern United States, highlights regional differences in circulating strains. Vet. Microbiol. 211, 174–179.

    4. Killian, M.L., 2014. Hemagglutination assay for influenza virus. Methods Mol. Biol. 1161, 3–9.

    5. Li, X., Guo, L., Liu, C., Cheng, Y., Kong, M., Yang, L., Zhuang, Z., Liu, J., Zou, M., Dong, X., Su, X., Gu, Q., 2019. Human infection with a novel reassortant Eurasian-avian lineage swine H1N1 virus in northern China. Emerg. Microb. Infect. 8, 1535–1545.

    6. Liang, H., Lam, T.T., Fan, X., Chen, X., Zeng, Y., Zhou, J., Duan, L., Tse, M., Chan, C.H., Li, L., Leung, T.Y., Yip, C.H., Cheung, C.L., Zhou, B., Smith, D.K., Poon, L.L., Peiris, M., Guan, Y., Zhu, H., 2014. Expansion of genotypic diversity and establishment of 2009 H1N1 pandemic-origin internal genes in pigs in China. J. Virol. 88, 10864–10874.

    7. Parys, A., Vandoorn, E., King, J., Graaf, A., Pohlmann, A., Beer, M., Harder, T., Van Reeth, K., 2021. Human infection with Eurasian avian-like swine influenza A(H1N1) virus, The Netherlands, september 2019. Emerg. Infect. Dis. 27, 939–943.

    8. Pensaert, M., Ottis, K., Vandeputte, J., Kaplan, M.M., Bachmann, P.A., 1981. Evidence for the natural transmission of influenza A virus from wild ducts to swine and its potential importance for man. Bull. World Health Organ. 59, 75–78.

    9. Peacock, T.P., Swann, O.C., Salvesen, H.A., Staller, E., Leung, P.B., Goldhill, D.H., Zhou, H., Lillico, S.G., Whitelaw, C.B.A., Long, J.S., Barclay, W.S., 2020. Swine ANP32A supports avian influenza virus polymerase. J. Virol. 94.

    10. Shope, R.E., 1931. Swine influenza: I. Experimental transmission and pathology. J. Exp. Med. 54, 349–359.

    11. Smith, G.J., Vijaykrishna, D., Bahl, J., Lycett, S.J., Worobey, M., Pybus, O.G., Ma, S.K., Cheung, C.L., Raghwani, J., Bhatt, S., Peiris, J.S., Guan, Y., Rambaut, A., 2009. Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature 459, 1122–1125.

    12. Sun, H., Xiao, Y., Liu, J., Wang, D., Li, F., Wang, C., Li, C., Zhu, J., Song, J., Sun, H., Jiang, Z., Liu, L., Zhang, X., Wei, K., Hou, D., Pu, J., Sun, Y., Tong, Q., Bi, Y., Chang, K.C., Liu, S., Gao, G.F., Liu, J., 2020. Prevalent Eurasian avian-like H1N1 swine influenza virus with 2009 pandemic viral genes facilitating human infection. Proc. Natl. Acad. Sci. U. S. A. 117, 17204–17210.

    13. Sun, Y.F., Wang, X.H., Li, X.L., Zhang, L., Li, H.H., Lu, C., Yang, C.L., Feng, J., Han, W., Ren, W.K., Tian, X.X., Tong, G.Z., Wen, F., Li, Z.J., Gong, X.Q., Liu, X.M., Ruan, B.Y., Yan, M.H., Yu, H., 2016. Novel triple-reassortant H1N1 swine influenza viruses in pigs in Tianjin, Northern China. Vet. Microbiol. 183, 85–91.

    14. Vijaykrishna, D., Poon, L.L., Zhu, H.C., Ma, S.K., Li, O.T., Cheung, C.L., Smith, G.J., Peiris, J.S., Guan, Y., 2010. Reassortment of pandemic H1N1/2009 influenza A virus in swine. Science 328, 1529.

    15. Vijaykrishna, D., Smith, G.J., Pybus, O.G., Zhu, H., Bhatt, S., Poon, L.L., Riley, S., Bahl, J., Ma, S.K., Cheung, C.L., Perera, R.A., Chen, H., Shortridge, K.F., Webby, R.J., Webster, R.G., Guan, Y., Peiris, J.S., 2011. Long-term evolution and transmission dynamics of swine influenza A virus. Nature 473, 519–522.

    16. Vincent, A., Awada, L., Brown, I., Chen, H., Claes, F., Dauphin, G., Donis, R., Culhane, M., Hamilton, K., Lewis, N., Mumford, E., Nguyen, T., Parchariyanon, S., Pasick, J., Pavade, G., Pereda, A., Peiris, M., Saito, T., Swenson, S., Van Reeth, K., Webby, R., Wong, F., Ciacci-Zanella, J., 2014. Review of influenza A virus in swine worldwide: a call for increased surveillance and research. Zoonoses Public Health 61, 4–17.

    17. Wang, D.Y., Qi, S.X., Li, X.Y., Guo, J.F., Tan, M.J., Han, G.Y., Liu, Y.F., Lan, Y., Yang, L., Huang, W.J., Cheng, Y.H., Zhao, X., Bai, T., Wang, Z., Wei, H.J., Xiao, N., Shu, Y.L., 2013. Human infection with Eurasian avian-like influenza A(H1N1) virus, China. Emerg. Infect. Dis. 19, 1709–1711.

    18. Zhu, W., Zhang, H., Xiang, X., Zhong, L., Yang, L., Guo, J., Xie, Y., Li, F., Deng, Z., Feng, H., Huang, Y., Hu, S., Xu, X., Zou, X., Li, X., Bai, T., Chen, Y., Li, Z., Li, J., Shu, Y., 2016. Reassortant Eurasian avian-like influenza A(H1N1) virus from a severely ill child, hunan province, China, 2015. Emerg. Infect. Dis. 22, 1930–1936.

  • 加载中
  • 10.1016j.virs.2022.04.009-ESM.docx

Article Metrics

Article views(2150) PDF downloads(20) Cited by(0)

Related
Proportional views
    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Genetic characterization and pathogenicity of a reassortant Eurasian avian-like H1N1 swine influenza virus containing an internal gene cassette from 2009 pandemic H1N1 virus

      Corresponding author: Hai Yu, haiyu_008@126.com
    • a Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No. 518, Ziyue Road, Minhang District, Shanghai, 200241, China;
    • b Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, China

    Abstract: Highlights
    1. Identification of a reassortant EA H1N1 SIV (SD/18) which isolated from a pig farm in Shandong, north China.
    2. Phylogenetic analysis showed that SD/18 virus containing a complete internal gene cassette from pdm/09 virus.
    3. The results of pathogenicity in mice showed that the mortality rate of SD/18 virus in mice could reach 100%.
    4. The potential risk of EA lineage SIVs to humans is very high and we need to pay enough attention to the different reassortant EA H1N1 viruses.

    Reference (18)

    目录

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return