The Observation on the Antiviral Effect of Ribavirin and Combining with Interferon in Patients with Chronic Hepatitis B

HUANG Hua-Fang; XIONG Kai-Jun; HE Sheng-Song; LI Yuan; WANG Ping; CA Shu-Qing; ZENG Lin-Lan; WANG Xin-He

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June 1991

HUANG Hua-Fang, XIONG Kai-Jun, HE Sheng-Song, LI Yuan, WANG Ping, CA Shu-Qing, ZENG Lin-Lan and WANG Xin-He. The Observation on the Antiviral Effect of Ribavirin and Combining with Interferon in Patients with Chronic Hepatitis B[J]. Virologica Sinica, 1991, 6(3).

Citation: HUANG Hua-Fang, XIONG Kai-Jun, HE Sheng-Song, LI Yuan, WANG Ping, CA Shu-Qing, ZENG Lin-Lan, WANG Xin-He. The Observation on the Antiviral Effect of Ribavirin and Combining with Interferon in Patients with Chronic Hepatitis B .VIROLOGICA SINICA, 1991, 6(3) : 201.

病毒唑及其与干扰素联合对慢性乙型肝炎抗病毒效应观察

1.
同济医科大学协和医院传染病教研组
2.
同济医科大学协和医院传染病教研组武汉

摘要

本文报道了病毒唑及其与干扰素联合对23例慢乙肝近、远期抗病毒效应观察结果,并与12例未经抗病毒治疗的慢乙肝作对照(Ⅲ组),其中病毒唑与干扰素联合组(I组)12例,病毒唑组(Ⅱ组)11例。近期HBeAg、DNAP及HBV?DNA阴转率,I组分别为(41.6％、55.5％及28.s％,Ⅱ组45.4％、100％及33.3％,Ⅲ组8.3％、16.6％及8.3％。远期HBeAg及DNAP阴转率在I组分别为70％、83.7％。Ⅱ组60％、100％,Ⅲ组8.3％,50％。综合抗病毒效应,近期有效率在I、Ⅱ、Ⅲ组分别为50％、72.7％及16.6％。远期则分别为70％、55.5％及8.3％。无一例出现毒副反应。均完成疗程。上述结果提示病毒唑及其与干扰素联合对慢乙肝均有一定抗病毒效应,联合应用并不优于单一用药,但毒副反应也未见加重,而且病毒唑药源较方便,使用较安全,值得进一步研究。
- 病毒唑
- , 干扰素
- , 慢乙肝
- , 抗病毒效应

The Observation on the Antiviral Effect of Ribavirin and Combining with Interferon in Patients with Chronic Hepatitis B

1.
Department of Infectious Disease
2.
Union Hospital

Abstract

In this paper) the recent and followed-up antiviral effect was observed in 23 patient with chronic hepatitis Bo Among them) the group of ribavirin combining with interferon(Group Ⅰ)was 12 cases) and the group of ribavirin (Group Ⅱ)was Ⅱ cases. The contrast group, who was treated without antivial drugs, was 12 cases. The recent negative percentage of HBeAg, DNAP, HBV DNA was41.6%, 55.5%, 28.5% in group Ⅰ, 45.5% 100%, 33.3% in group Ⅱ , and 8.3%) 16.6% 8.3% in the contrast group. The followed-up negative perc...
- Ribavirin Interferon Chronic hepatitis B Antiviral effect

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

The Observation on the Antiviral Effect of Ribavirin and Combining with Interferon in Patients with Chronic Hepatitis B

1. Department of Infectious Disease
2. Union Hospital

Abstract: In this paper) the recent and followed-up antiviral effect was observed in 23 patient with chronic hepatitis Bo Among them) the group of ribavirin combining with interferon(Group Ⅰ)was 12 cases) and the group of ribavirin (Group Ⅱ)was Ⅱ cases. The contrast group, who was treated without antivial drugs, was 12 cases. The recent negative percentage of HBeAg, DNAP, HBV DNA was41.6%, 55.5%, 28.5% in group Ⅰ, 45.5% 100%, 33.3% in group Ⅱ , and 8.3%) 16.6% 8.3% in the contrast group. The followed-up negative perc...