EFFECT OF SMALL DOSAGE OF INTERFERON ON VIRAL MARKERS OF CHRONIC HEPATITIS B

XIONG Kai-Jun; WANG Xin-He; JIN Wei-E; HUANG Hua-Fang; TAO Meng-Lin; ZENG Lian-Lan; HAN Cai-Yang; FAN Hong-Mei; WU Zhang-Qi; SUN Ji-Shan

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April 1986

XIONG Kai-Jun, WANG Xin-He, JIN Wei-E, HUANG Hua-Fang, TAO Meng-Lin, ZENG Lian-Lan, HAN Cai-Yang, FAN Hong-Mei, WU Zhang-Qi and SUN Ji-Shan. EFFECT OF SMALL DOSAGE OF INTERFERON ON VIRAL MARKERS OF CHRONIC HEPATITIS B[J]. Virologica Sinica, 1986, 1(2).

Citation: XIONG Kai-Jun, WANG Xin-He, JIN Wei-E, HUANG Hua-Fang, TAO Meng-Lin, ZENG Lian-Lan, HAN Cai-Yang, FAN Hong-Mei, WU Zhang-Qi, SUN Ji-Shan. EFFECT OF SMALL DOSAGE OF INTERFERON ON VIRAL MARKERS OF CHRONIC HEPATITIS B .VIROLOGICA SINICA, 1986, 1(2) : 9.

小剂量干扰素对慢性乙型肝炎病毒标志物的影响

1.
同济医大协和医院传染病教研室
2.
中国科学院武汉病毒研究所
3.
中国科学院武汉病毒研究所武汉

摘要

本文用小剂量人白细胞干扰素治疗慢性乙型肝炎(30例)及病毒携带者(10例)共40例,干扰素32.000u,肌肉注射,每周3次,治疗观察6个月。其 HBsAg 滴度几何平均值从治疗前1:100.4,3个月下降为1:25.1,6个月为1:17.2,P<0.001,HBsAg 转阴21/40例,占52.5%。6个月后,HBeAg 13/20例转阴,占65%,有抗一 HBe 出现11例;HBcAg2/4例转阴,88.9%的病例 DNAP 为阴性,73.1%的病例 HBV-DNA 为阴性伴 DNAP 阴性。30例肝炎病人的病毒指标转阴优于病毒携带者。对照组20例用聚肌胞治疗6个月,病毒指标无明显改善。从以上五项病毒指标在治疗后下降和转阴,表明小剂量干扰素对乙肝病毒复制有抑制作用。

EFFECT OF SMALL DOSAGE OF INTERFERON ON VIRAL MARKERS OF CHRONIC HEPATITIS B

1.
Dèpartment of infectious disease
2.
Xiehe hospital
3.
Tongji medical university

Abstract

40 cases including chronic hepatitis B(30cases)and viral carriers(10 cases)were treated with interferon 32,ooo iu im,q.o.d,in a period of six months.The geometric average of HBsAg titer fall from 1:100.4 to 1:17.2 at the sixth months(P<0.001).21 of them(52、5%)became negat- ive.After six months 13 of 20 HBeAg positive cases turned into negative, anti-HBe appeared in 11 cases.With the four HBcAg positive cases,two of them became negative.DNAP were negative in 88.9% cases.73.1% pati- ents are negative for H...

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

EFFECT OF SMALL DOSAGE OF INTERFERON ON VIRAL MARKERS OF CHRONIC HEPATITIS B

1. Dèpartment of infectious disease
2. Xiehe hospital
3. Tongji medical university

Abstract: 40 cases including chronic hepatitis B(30cases)and viral carriers(10 cases)were treated with interferon 32,ooo iu im,q.o.d,in a period of six months.The geometric average of HBsAg titer fall from 1:100.4 to 1:17.2 at the sixth months(P<0.001).21 of them(52、5%)became negat- ive.After six months 13 of 20 HBeAg positive cases turned into negative, anti-HBe appeared in 11 cases.With the four HBcAg positive cases,two of them became negative.DNAP were negative in 88.9% cases.73.1% pati- ents are negative for H...