EXPERIMENTAL STUDIES IN THE TREATMENT OF JAPANESE B ENCEPHALITIS BY MONOCLONAL ANTIBODIES

ZHANG Ming-Jie; WANG Mei-Xian; JIANG Shao-Chun; MA Wen-Yu

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August 1987

ZHANG Ming-Jie, WANG Mei-Xian, JIANG Shao-Chun and MA Wen-Yu. EXPERIMENTAL STUDIES IN THE TREATMENT OF JAPANESE B ENCEPHALITIS BY MONOCLONAL ANTIBODIES[J]. Virologica Sinica, 1987, 2(4).

Citation: ZHANG Ming-Jie, WANG Mei-Xian, JIANG Shao-Chun, MA Wen-Yu. EXPERIMENTAL STUDIES IN THE TREATMENT OF JAPANESE B ENCEPHALITIS BY MONOCLONAL ANTIBODIES .VIROLOGICA SINICA, 1987, 2(4) : 27.

单克隆抗体治疗日本乙型脑炎的实验研究

1.
第四军医大学微生物学教研室
2.
第四军医大学微生物学教研室西安

摘要

本文应用JEV-McAb对感染JEV的小白鼠及幼山羊进行实验性治疗,并对乙脑免疫机理作一初步探讨。结果表明,JEV-McAb对经不同途径感染各种JEV毒株的小白鼠都有较好的保护作用,其效果明显优于PeAb。小鼠感染后120小时,大部分已发病,个别已濒死,这时给予混合MeAb或其F(ab′)2,仍可保护约半数存活。McAb对感染JEV的幼羊也有较好的保护作用。羊脑内注入JEV48小时后,出现发热不安等症状,这时由腹腔和椎管两种途径同时给予混合McAb,保护率达100％。存活实验动物脑组织内未分离出病毒;而死亡功物病毒分离阳性,脑组织经双PAP及HE染色证实JEV抗原阳性并伴有脑炎的病理改变。中和活性是JEV-McAb的主要保护方式,中和放价高的MeAb保护率也高。

EXPERIMENTAL STUDIES IN THE TREATMENT OF JAPANESE B ENCEPHALITIS BY MONOCLONAL ANTIBODIES

1.
Dep. of Microbiology
2.
the 4th Military Med. College

Abstract

The anti-JEV McAb is tried out to treat the mice and goats which have infected by JEV,Tbc results show that the JEV-McAbs have an excellent curative effect to several JEV-infeeted mice.It is evidently better than that of the PeAb. After 120 hours of infection, most of the mice have already had the signs of JE,some were nearly dead. If McAb or their F(ab )_2 were given even at this time, approximately half of the mice could be saved from JE. M-MeAb has an evident protective effect in the goats too. After 48 ...

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

EXPERIMENTAL STUDIES IN THE TREATMENT OF JAPANESE B ENCEPHALITIS BY MONOCLONAL ANTIBODIES

1. Dep. of Microbiology
2. the 4th Military Med. College

Abstract: The anti-JEV McAb is tried out to treat the mice and goats which have infected by JEV,Tbc results show that the JEV-McAbs have an excellent curative effect to several JEV-infeeted mice.It is evidently better than that of the PeAb. After 120 hours of infection, most of the mice have already had the signs of JE,some were nearly dead. If McAb or their F(ab )_2 were given even at this time, approximately half of the mice could be saved from JE. M-MeAb has an evident protective effect in the goats too. After 48 ...