Pathological Observation of Salivary Gland and Spleen in the Newborn Guinea Pigs with Acute Cytomegalovirus Infection

ZHENG Zhi-Ming; LIN Na; ZHANG Wei-Ying; ZHANG Jiang-Hong; ZHU Wei-Ping; HU Jian-Ming

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June 1988

ZHENG Zhi-Ming, LIN Na, ZHANG Wei-Ying, ZHANG Jiang-Hong, ZHU Wei-Ping and HU Jian-Ming. Pathological Observation of Salivary Gland and Spleen in the Newborn Guinea Pigs with Acute Cytomegalovirus Infection[J]. Virologica Sinica, 1988, 3(3).

Citation: ZHENG Zhi-Ming, LIN Na, ZHANG Wei-Ying, ZHANG Jiang-Hong, ZHU Wei-Ping, HU Jian-Ming. Pathological Observation of Salivary Gland and Spleen in the Newborn Guinea Pigs with Acute Cytomegalovirus Infection .VIROLOGICA SINICA, 1988, 3(3) : 258.

新生豚鼠巨细胞病毒感染后唾液腺和脾脏的病理改变

1.
湖北医学院病毒研究所
2.
内蒙古医学院微生物教研室
3.
湖北医学院病毒研究所武汉
4.
进修教师

摘要

豚鼠皮下接种巨细胞病毒(CMV)后,出现发育迟缓、唾液腺和脾脏肿大,唾液腺中出现高滴度的CMV。镜检唾液腺和脾脏发现有唾液腺导管细胞变性和导管细胞核内嗜酸性包涵体;脾脏中性粒细胞浸润、散在的灶状出血、大量网状内皮细胞增生、脾小结增大甚至急性窦卡他性炎症。

Pathological Observation of Salivary Gland and Spleen in the Newborn Guinea Pigs with Acute Cytomegalovirus Infection

1.
Virus Research Institute
2.
Hubei Medical College
3.
Wuhan

Abstract

Subcutaneous inoculation of guinea pig cytomegalovirus (CMV) into newborn guinea pigs resulted in acute CMV infection of the animals. Guinea pigs Infected had growth retardation, salivary gland swelling, and splenomegaly. Virus could be recovered from salivary gland 5 days after ineeulation and the infectivity titers of CMV reached to a high titer of 3.7 log_(10)TCID_(50)/0.1 ml of 10％ salivary gland suspensions 16 days after inoculation, Histopathological examination showed that CMV mainly caused degenerat...

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Pathological Observation of Salivary Gland and Spleen in the Newborn Guinea Pigs with Acute Cytomegalovirus Infection

1. Virus Research Institute
2. Hubei Medical College
3. Wuhan

Abstract: Subcutaneous inoculation of guinea pig cytomegalovirus (CMV) into newborn guinea pigs resulted in acute CMV infection of the animals. Guinea pigs Infected had growth retardation, salivary gland swelling, and splenomegaly. Virus could be recovered from salivary gland 5 days after ineeulation and the infectivity titers of CMV reached to a high titer of 3.7 log_(10)TCID_(50)/0.1 ml of 10％ salivary gland suspensions 16 days after inoculation, Histopathological examination showed that CMV mainly caused degenerat...