The Contrast Observation of Antiviral Effect of Interferon with Two Different Dosages in Chronic Hepatitis B

HUANG Hua-Fang; XIONG Kai-Jun; WANG Xin-He; CENG Lin-Lan; LI Yuan; HE Yong-Wen; YANG Ze-Chuan; LING Mei-Xia; FAN Jia-Zhen; TUN Zhang-Qi

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August 1989

HUANG Hua-Fang, XIONG Kai-Jun, WANG Xin-He, CENG Lin-Lan, LI Yuan, HE Yong-Wen, YANG Ze-Chuan, LING Mei-Xia, FAN Jia-Zhen and TUN Zhang-Qi. The Contrast Observation of Antiviral Effect of Interferon with Two Different Dosages in Chronic Hepatitis B[J]. Virologica Sinica, 1989, 4(4).

Citation: HUANG Hua-Fang, XIONG Kai-Jun, WANG Xin-He, CENG Lin-Lan, LI Yuan, HE Yong-Wen, YANG Ze-Chuan, LING Mei-Xia, FAN Jia-Zhen, TUN Zhang-Qi. The Contrast Observation of Antiviral Effect of Interferon with Two Different Dosages in Chronic Hepatitis B .VIROLOGICA SINICA, 1989, 4(4) : 383.

人白细胞干扰素两种不同制剂对慢性乙型肝炎抗病毒效应的对比观察

1.
同济医科大学附属协和医院传染病教研室
2.
中国科学院武汉病毒研究所武汉

摘要

本文报道了人白细胞干扰素两种不同制剂对44例慢性乙肝近,远期抗病毒效应的对比观察结果,其中Ⅰ组23例,Ⅱ组21例,Ⅰ组剂量为1×10~6u/次,im每周3次,共四周后改为1×10~6u/次,每周2次,共6周,总计10周为一疗程,Ⅱ组6×10~4u/次im,每周3次,6个月一个疗程,治毕近期效应在HBeAg,HBcAg,DNA-P及HBV-DNA阴转率及总有效率方面,Ⅰ组分别为52.1％,30％,0％,7.1％及52.1％;Ⅱ组分别为72.2％,50％,60％,28.5％及68.3％。治后进行半年以上追踪观察,Ⅰ组20例,Ⅱ组21例,远期效应,在HBeAg,HBcAg,DNAP,HBV-DNA,阴转率及总有效率方面,Ⅰ组分别为40％,33.3%,66.6％,33.3％及40％;Ⅱ组分别为70％,66.6％,80%,60％及71.4％,经统计学处理,两组近、远期HBV复制指标阴转率及总有效率均无显著差异(HBeAg除外),Ⅰ组抗病毒效应并不优于Ⅱ组。扼要讨论两组疗效相近的因素,认为Ⅰ组适当调整剂量及疗程有可能提高疗效,并讨论了治程中肝功能改变的意义,两组均未出现明显的副反应,是较安全的。
- 干扰素
- , 乙型肝炎
- , 抗病毒效应

The Contrast Observation of Antiviral Effect of Interferon with Two Different Dosages in Chronic Hepatitis B

1.
Department of Infectious Disease
2.
Union Hospital

Abstract

In this paper, the recent and followed-up contrast observation was taken on 44 cases with chronic hepatitis B, who had been treated with two different dosages of interferon. There were 23 cases in group Ⅰ and 21 cases in group Ⅱ. The dosage of group Ⅰ was 1×10~6 iu im 3/w x 4 weeks, then returned to 1×10~6 iu im 2/w x 6 weeks. The total course was 10 weeks. The dosage of group Ⅱ was 6×10~4 iu im qod. The total course was 6 months. When the course of treatment was finished, the recent effect which reflected ...
- Interferon
- , Hepatitis B
- , Antiviral effect

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

The Contrast Observation of Antiviral Effect of Interferon with Two Different Dosages in Chronic Hepatitis B

1. Department of Infectious Disease
2. Union Hospital

Abstract: In this paper, the recent and followed-up contrast observation was taken on 44 cases with chronic hepatitis B, who had been treated with two different dosages of interferon. There were 23 cases in group Ⅰ and 21 cases in group Ⅱ. The dosage of group Ⅰ was 1×10~6 iu im 3/w x 4 weeks, then returned to 1×10~6 iu im 2/w x 6 weeks. The total course was 10 weeks. The dosage of group Ⅱ was 6×10~4 iu im qod. The total course was 6 months. When the course of treatment was finished, the recent effect which reflected ...