Comparative Studies on the Immunogenicity of Different Types of HFRS Inactivated Vaccine

YU Yong-Xin; Dong Guan-Mu; Tao-Xiao-Jian; LIU Wen-Xue; An-Qi; LI Zheng-Ping

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February 1990

YU Yong-Xin, Dong Guan-Mu, Tao-Xiao-Jian, LIU Wen-Xue, An-Qi and LI Zheng-Ping. Comparative Studies on the Immunogenicity of Different Types of HFRS Inactivated Vaccine[J]. Virologica Sinica, 1990, 5(1).

Citation: YU Yong-Xin, Dong Guan-Mu, Tao-Xiao-Jian, LIU Wen-Xue, An-Qi, LI Zheng-Ping. Comparative Studies on the Immunogenicity of Different Types of HFRS Inactivated Vaccine .VIROLOGICA SINICA, 1990, 5(1) : 63.

各种类型流行性出血热灭活疫苗的免疫性比较研究

1.
中国药品生物制品检定所
2.
中国药品生物制品检定所北京

摘要

本文对三种不同类型的出血热疫苗的免疫性进行了比较研究,其中沙鼠肾细胞疫苗由β—丙内酯灭活不加任何佐剂,地鼠肾细胞和鼠脑提纯疫苗由福尔马林灭活加氢氧化铝佐剂。三种疫苗经抗原量测定结果只有沙鼠肾细胞疫苗能测出较高的血凝素。家兔经三种疫苗免疫二针后只有沙鼠肾细胞疫苗能测出血抑抗体。中和抗体测定的结果亦以该疫苗的抗体反应最好,全部阳转,滴度也最高(1:20—≥320)。对家兔和长爪沙鼠免疫后用野鼠型病毒攻击结果,三种疫苗均有一定的保护作用,但仍以沙鼠肾细胞疫苗的保护力最强。
- 流行性出血热病毒
- , 灭活疫苗
- , 免疫性

Comparative Studies on the Immunogenicity of Different Types of HFRS Inactivated Vaccine

1.
Nationol Institute for the Control of Pharmaceutical and Biological Products
2.
Beijing 100050

Abstract

The immunogencity was studied for three types of experimental inaetiva ted haemorrhagic fever with renal syndrome (HFRS)vaccine, two tissue cul ture vaccines made from Mongolian Gerbil kidney and hamster kidney and one purified mouse brain vaccine. The M Gerbil kidney cell vaccine was made with Z_(10) virus strain (Apodemus type )and inactivated by β-propiolactone. The mouse brain vaccine made with LR1 virus strain(Apodmus type)and the hamster kidney cell vaccine made with a combination of Apodmus type viru...
- Haemorrhagic fever with renal syndrome viruses Inactivated vaccine Immuongenicity

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Comparative Studies on the Immunogenicity of Different Types of HFRS Inactivated Vaccine

1. Nationol Institute for the Control of Pharmaceutical and Biological Products
2. Beijing 100050

Abstract: The immunogencity was studied for three types of experimental inaetiva ted haemorrhagic fever with renal syndrome (HFRS)vaccine, two tissue cul ture vaccines made from Mongolian Gerbil kidney and hamster kidney and one purified mouse brain vaccine. The M Gerbil kidney cell vaccine was made with Z_(10) virus strain (Apodemus type )and inactivated by β-propiolactone. The mouse brain vaccine made with LR1 virus strain(Apodmus type)and the hamster kidney cell vaccine made with a combination of Apodmus type viru...