Inhibitory Effect of CSF-1 on Human Common Respiratory Tract Viruses in Vitro

YAO Kun; ZHOU Yao-Xi; WU Xiao-Ling; ZHOU Feng; ZHU De-Xu; TAO Xu

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August 1990

YAO Kun, ZHOU Yao-Xi, WU Xiao-Ling, ZHOU Feng, ZHU De-Xu and TAO Xu. Inhibitory Effect of CSF-1 on Human Common Respiratory Tract Viruses in Vitro[J]. Virologica Sinica, 1990, 5(4).

Citation: YAO Kun, ZHOU Yao-Xi, WU Xiao-Ling, ZHOU Feng, ZHU De-Xu, TAO Xu. Inhibitory Effect of CSF-1 on Human Common Respiratory Tract Viruses in Vitro .VIROLOGICA SINICA, 1990, 5(4) : 347.

人集落刺激因子-1(CSF-1)对常见呼吸道病毒的抑制作用

1.
南京医学院微生物学教研究室
2.
南京大学生物化学系
3.
南京大学生物化学系南京

摘要

本文观察集落刺激因子-1(CSF-1)及其诱生剂:内毒素(LPS)、胞壁二肽(MDP)和干扰素(IFN-α)对下列病毒所致细胞病变的抑制,包括不同型别腺病毒5株,单疱病毒Ⅰ型和Ⅱ型,流感病毒A_3型,鼻病毒,ECHO11型各1株,在人胚肺传代细胞株上病变抑制的结果如下:对HSV-1、HSV-2、腺病毒6、11、22型,流感A_3型,鼻病毒。(CSF-1)和IFN-α,一样有明显抑毒效果,LPS+MDP联合使用对以上病毒有明显增强抑毒作用。CSF-1和IFN-α的抑毒作用能分别被CSF-1和IFN-α的抗体所解除。 CSF-1在人胚肺传代细胞和人胚皮肤肌肉传代细胞上对VSV的抑毒效果在人胚肺细胞中效果比人胚皮肤肌肉细胞更明显。LPS10ng/ml作用48小时比作用24小时效果更强。LPS+MDP和IFN-α对二种细胞都有同样高效的抑毒作用。
- 集落刺激因子-1
- , 呼吸道病毒

Inhibitory Effect of CSF-1 on Human Common Respiratory Tract Viruses in Vitro

1.
Department of Microbiology
2.
Nanjing Medical College
3.
Nanjing 210002Department of Biochemistry

Abstract

This paper reports the protective effect of human CSF-1 on human fibroblast cultures infected by viruses in vitro, that is, before virus challenge, the treatment of cell cultures with CSF-1 may result in the inhibition of virus replication and virus-induced cytopathy. The challenge viruses included 2 strains of HSV, 1 strain of influenza A_3 virus, 1 strain of ECHO-11 virus, 5 strains of different serotypes of adenovirus, 1 strain of rhinovirus and 1 strain of VSV. The activity of CSF-1 was specific, it was...
- Colony stimulating factor 1
- , Respiratory viruses

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Inhibitory Effect of CSF-1 on Human Common Respiratory Tract Viruses in Vitro

1. Department of Microbiology
2. Nanjing Medical College
3. Nanjing 210002Department of Biochemistry

Abstract: This paper reports the protective effect of human CSF-1 on human fibroblast cultures infected by viruses in vitro, that is, before virus challenge, the treatment of cell cultures with CSF-1 may result in the inhibition of virus replication and virus-induced cytopathy. The challenge viruses included 2 strains of HSV, 1 strain of influenza A_3 virus, 1 strain of ECHO-11 virus, 5 strains of different serotypes of adenovirus, 1 strain of rhinovirus and 1 strain of VSV. The activity of CSF-1 was specific, it was...