Inhibitory Effect of HSV Infection in Vitro on IgG and Effect of TNF and r-IFN on It

CAO Zhi-Hui; CHEN Shen-Bao; DING Ru-Ning; ZHOU Yao-Xi

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June 1991

CAO Zhi-Hui, CHEN Shen-Bao, DING Ru-Ning and ZHOU Yao-Xi. Inhibitory Effect of HSV Infection in Vitro on IgG and Effect of TNF and r-IFN on It[J]. Virologica Sinica, 1991, 6(3).

Citation: CAO Zhi-Hui, CHEN Shen-Bao, DING Ru-Ning, ZHOU Yao-Xi. Inhibitory Effect of HSV Infection in Vitro on IgG and Effect of TNF and r-IFN on It .VIROLOGICA SINICA, 1991, 6(3) : 183.

HSV体外感染对IgG产生的抑制作用和TNF及r-IFN对它的影响

1.
南京医学院微生物教研室
2.
南京医学院微生物教研室南京

摘要

本文观察了体外HSV-I感染对人淋巴细胞增殖、分化,产生免疫球蛋白的影响。HSV-I能感染PWM刺激的人扁桃体淋巴细胞,并抑制其增殖和免疫球蛋白(IgG)的产生,感染实验组的IgG产量较对照组明显降低(P0.05),但r-IFN_γ对TNF有协同作用:抑制病毒增殖和解除HSV-I对IgG产生的抑制,比单独用TNF组更为显著(P<0.01)。
- 单纯疱疹病毒
- , 人淋巴细胞
- , 免疫球蛋白G产生
- , 肿瘤坏死因子
- , 干扰素

Inhibitory Effect of HSV Infection in Vitro on IgG and Effect of TNF and r-IFN on It

1.
Dept.of Microbiology
2.
Nanjing Medical College

Abstract

We successfully established a system in vitro that HSV-Ⅰ infected human tonsillar lymphocytes. Tonsillar lymphocytes prestimulated with PWM(10μg/ml) were infected by living HSV-Ⅰ, so as to their proliferation and IgG synthesis were abated significantly(P<0.005).In the supernatants, the infective titers ofHSV-Ⅰ were about 10~(3?2)—10~(5?7) TCID_(50)/ml,number of viral antigen positive cells about 3％—8％.We found that some lymphokine and monokine can dampen the inhibition of infection of infectious HSV-Ⅰ Th...
- Herpes simplex virus Human lymphcytes IgG production Tumor necrosis factor Interferon

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Inhibitory Effect of HSV Infection in Vitro on IgG and Effect of TNF and r-IFN on It

1. Dept.of Microbiology
2. Nanjing Medical College

Abstract: We successfully established a system in vitro that HSV-Ⅰ infected human tonsillar lymphocytes. Tonsillar lymphocytes prestimulated with PWM(10μg/ml) were infected by living HSV-Ⅰ, so as to their proliferation and IgG synthesis were abated significantly(P<0.005).In the supernatants, the infective titers ofHSV-Ⅰ were about 10~(3?2)—10~(5?7) TCID_(50)/ml,number of viral antigen positive cells about 3％—8％.We found that some lymphokine and monokine can dampen the inhibition of infection of infectious HSV-Ⅰ Th...