Efficacy of Inactivated EHF Vaccine Used in Clinical Trial

ZHU Zhi-Yong; ZENG Rong-Fang; SHU Yong-Xin

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August 1991

ZHU Zhi-Yong, ZENG Rong-Fang and SHU Yong-Xin. Efficacy of Inactivated EHF Vaccine Used in Clinical Trial[J]. Virologica Sinica, 1991, 6(4).

Citation: ZHU Zhi-Yong, ZENG Rong-Fang, SHU Yong-Xin. Efficacy of Inactivated EHF Vaccine Used in Clinical Trial .VIROLOGICA SINICA, 1991, 6(4) : 315.

EHF灭活疫苗扩大人体试用的效果观察

1.
浙江省卫生防疫站
2.
上海生物制品研究所
3.
中国药品生物制品检定所杭州

摘要

流行性出血热(EHF)沙鼠肾细胞灭活疫苗,经75名自愿者扩大试用,未发现不良反应。中和抗体阳转率达70.6～96.7％,4℃保存14个月的疫苗,仍有较高的中和抗体阳转率,再一次证明此疫苗是安全有效的,且有良好的稳定性。接种程序为0、7、28天内三次免疫与0、28、60天内三次免疫无明显差别。皮下接种佐剂苗产生的中和抗体滴度高于肌肉接种的佐剂苗和疫苗。
- EHF灭活疫苗
- , 人体试用

Efficacy of Inactivated EHF Vaccine Used in Clinical Trial

1.
Zhejiang Health and Anti-epidemic Station
2.
Hangzhou 310009Shanghai Institute of Biological Products
3.
Shanghai National Institute for the Control of Pharmaceutical and Biological Products

Abstract

The inactivated EHF vaccine was used inclinincal trial with 75 volunteers. There was not any side effects. It showed that abaut 90% seroconversion rate of neutraliztion antibody occurred. The vaccine stored for 14 months in 4℃ still had better immunogenicity. It was shown for the second time that the vaccine was safe, affeetive and very stable. The immunization procedure of 3×1ml during 28 days and of 3×1ml during 60 days showed no significant difference.
- Inactivated EHF vaccine
- , Clinical trial

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Efficacy of Inactivated EHF Vaccine Used in Clinical Trial

1. Zhejiang Health and Anti-epidemic Station
2. Hangzhou 310009Shanghai Institute of Biological Products
3. Shanghai National Institute for the Control of Pharmaceutical and Biological Products

Abstract: The inactivated EHF vaccine was used inclinincal trial with 75 volunteers. There was not any side effects. It showed that abaut 90% seroconversion rate of neutraliztion antibody occurred. The vaccine stored for 14 months in 4℃ still had better immunogenicity. It was shown for the second time that the vaccine was safe, affeetive and very stable. The immunization procedure of 3×1ml during 28 days and of 3×1ml during 60 days showed no significant difference.