Pathogenicity and Immunogenicity of Attenuated Japanese Encephalitis Vaccine (SA_(14)-14-2) in Immune-Inhibited Mice

JIA Li-Li; ZHENG Zheng; YU Yong-Xin

PDF
Cite
Share

facebook

twitter

google

linkedin

February 1993

JIA Li-Li, ZHENG Zheng and YU Yong-Xin. Pathogenicity and Immunogenicity of Attenuated Japanese Encephalitis Vaccine (SA_(14)-14-2) in Immune-Inhibited Mice[J]. Virologica Sinica, 1993, 8(1).

Citation: JIA Li-Li, ZHENG Zheng, YU Yong-Xin. Pathogenicity and Immunogenicity of Attenuated Japanese Encephalitis Vaccine (SA_(14)-14-2) in Immune-Inhibited Mice .VIROLOGICA SINICA, 1993, 8(1) : 20.

流行性乙型脑炎减毒活疫苗(SA_(14)-14-2)对免疫抑制剂处理小白鼠的致病性和免疫原性

1.
中国药品生物制品检定所
2.
中国药品生物制品检定所北京

摘要

免疫抑制剂环磷酰胺处理的12—14克三周龄小白鼠免疫功能抑制后,皮下注射乙脑SA_(14)—14—2减毒活疫苗,未见小鼠出现特异性死亡。同时发现对活疫苗和死疫苗的免疫反应明显不同,处理后小鼠对活苗免疫仍有较好的免疫力,保护率为56%(三次抑制)和80％(二次抑制);而死疫苗免疫力明显下降,未抑制组为100％,抑制后降到10～20%。若小白鼠经乙脑活苗、死苗免疫后四周已建立免疫力后,再用环磷酰胺处理,并用强毒株P_3攻毒,则对免疫反应影响不明显,两种疫苗均表现有较好的保护作用。
- 乙脑
- , 减毒活疫苗
- , 免疫抑制
- , 致病性
- , 免疫原性

Pathogenicity and Immunogenicity of Attenuated Japanese Encephalitis Vaccine (SA_(14)-14-2) in Immune-Inhibited Mice

1.
Notional Institute lor Conlro1 掳f Pharmaceutical and Biological Products
2.
Beijing 100050

Abstract

In this study, three-week-old mice, 12—14g, were treated by cytoxan three times. They were then injected subcutaneousiy with SA_(14)-14-2 live vaccine, no mouse was killed by the attenuated virus. When the immune-inhibited mice were immunized with the attenuated live vaccine and the inactivated JE vaccine, they exhibited different immune responses to the both vaccines. Those immunized with the attenuated live virus showed better protective effect (protective rate 56—80%)against JE virulent virus challenging...
- Japanese encephalitis
- , Attenuated live vaccine
- , Immune-inhibited
- , Pathogenicity
- , Immunogenicity

References
Proportional views

PDF

Article Metrics

Article views(3762) PDF downloads(774) Cited by(0)

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Pathogenicity and Immunogenicity of Attenuated Japanese Encephalitis Vaccine (SA_(14)-14-2) in Immune-Inhibited Mice

1. Notional Institute lor Conlro1 掳f Pharmaceutical and Biological Products
2. Beijing 100050

Abstract: In this study, three-week-old mice, 12—14g, were treated by cytoxan three times. They were then injected subcutaneousiy with SA_(14)-14-2 live vaccine, no mouse was killed by the attenuated virus. When the immune-inhibited mice were immunized with the attenuated live vaccine and the inactivated JE vaccine, they exhibited different immune responses to the both vaccines. Those immunized with the attenuated live virus showed better protective effect (protective rate 56—80%)against JE virulent virus challenging...