Polymerase chain reaction for detection of different types of tiuman papillomavirus ill tile cervix

CAI Hong; TAO Kun; CHEN Wei-Li; ZHOU Yao-Xi; YANG Zhi-Jian

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August 1994

CAI Hong, TAO Kun, CHEN Wei-Li, ZHOU Yao-Xi and YANG Zhi-Jian. Polymerase chain reaction for detection of different types of tiuman papillomavirus ill tile cervix[J]. Virologica Sinica, 1994, 9(4).

Citation: CAI Hong, TAO Kun, CHEN Wei-Li, ZHOU Yao-Xi, YANG Zhi-Jian. Polymerase chain reaction for detection of different types of tiuman papillomavirus ill tile cervix .VIROLOGICA SINICA, 1994, 9(4) : 291.

多聚酶链反应检测宫颈HPV感染及分型的研究

1.
南京医科大学微生物学教研室江苏省肿瘤防治研究所病毒室

摘要

本文应用ＰＣＲ技术检测２ｌ２例临床宫颈标本的ＨＰＶ－６、ｌｌ、１６、１８型特异性核酸序列。结果发现ＨＰＶ－ＤＮＡ的阳性率：宫颈癌组为６２．５％（２５／４０）．慢性宫颈炎为５７％（８１／１４２），正常宫颈对照组为２０％（６／３０），Ｐ＜０．００１，提示ＨＰＶ的感染与宫颈炎、宫颈癌有关。同时分型结果显示：ＨＰＶ－６、１６、１８型与宫颈炎相关，１６型与宫颈癌密切相关，且ＨＰＶ不同型别的混合感染在宫颈中普遍存在（３１．３％）。成年女性各年龄组间ＨＰＶ的感染率并无明显差异（Ｐ＞０．０５）。
- 多聚酶链反应人乳头瘤病毒宫颈炎宫颈癌

Polymerase chain reaction for detection of different types of tiuman papillomavirus ill tile cervix

1.
Dep. of Microbiology, Nanjing Medical University

Abstract

Polymerase Chain Reactiun(PCR)was used to detect HPV 6,11,16,18 type specific DNA se-quences in 2l2 clinical cervical samples.The pusitivity uf HPV-DNA was 62.5%(25/40)in patientswith cervical cancer(squamous cell)and 57%(81/142)in chronic cervicitis,markedly higher than20%(6/30)in hedlthy control(P0.05).
- Polymerase Chain Reaction Human Papillomavirus Cervicitis Cervical cancer

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Polymerase chain reaction for detection of different types of tiuman papillomavirus ill tile cervix

1. Dep. of Microbiology, Nanjing Medical University

Abstract: Polymerase Chain Reactiun(PCR)was used to detect HPV 6,11,16,18 type specific DNA se-quences in 2l2 clinical cervical samples.The pusitivity uf HPV-DNA was 62.5%(25/40)in patientswith cervical cancer(squamous cell)and 57%(81/142)in chronic cervicitis,markedly higher than20%(6/30)in hedlthy control(P0.05).