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Volume 10 Issue 1
February 1995

    ZHOU Sheng-Hua, DONG Ji-Hua and TIAN Mu-Zhen. Selection and Preliminary Characterization of Naturally OccurringTemperature—Sensitive Strains of Respir=ory Syncyfial Virus(RSV)[J]. Virologica Sinica, 1995, 10(1).
    Citation: ZHOU Sheng-Hua, DONG Ji-Hua, TIAN Mu-Zhen. Selection and Preliminary Characterization of Naturally Occurring Temperature—Sensitive Strains of Respir=ory Syncyfial Virus(RSV) .VIROLOGICA SINICA, 1995, 10(1) : 41.
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    呼吸道合胞病毒自然温度敏感株的研究 I．呼吸道合胞病毒自然温度敏感株的筛选及其特性的 初步研究

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      同济医科大学附属协和医院病毒室

    • 本文利用离心蚀斑法从武汉地区１９７８－１９８３年及１９８７－１９９２年的７３株呼吸道合胞病毒流行毒株中直接筛选出１７株自然温度敏感株，并以３３°／３９．５°Ｃ的ＩｇＰＦＵ相差≥３作为确定自然温度敏感株的标准。每年筛选出自然温度敏感株的比例平均为１５－ｌ７％；根据毒株温敏性状的差异，将呼吸道合胞病毒流行株分为ｔｓ￣＋，ｔｓ￣±与ｔｓ毒株；并初步发现Ｂ亚型毒株所含的自然温敏株的比例明显高于Ａ型毒株（Ｐ＜０，０５）。初步测定２株该自然温敏株的遗传稳定性，结果显示具有较稳定的特性。本文结果提示，呼吸道合胞病毒在自然界不仅存在Ａ，Ｂ两亚型变异，也存在温敏性状的变异，可能存在毒力的变异。

    Selection and Preliminary Characterization of Naturally Occurring Temperature—Sensitive Strains of Respir=ory Syncyfial Virus(RSV)

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      Dep. of Clinical 

    • Seventeen naturally occurring B strains of RSV selected directly from 73 strains circulating in nature． The ts character was exam ined by parallel plaque assay and reexam ined three times for each strain．Based oi"1 the 33℃ ／39．5℃ 1gPFU difference，the RSV circulating strains could be divided into three groups of strain，namely．Our study suggested that there a more naturally 0e curring ts strains arnmag the subtype B RSV than am ng subtype A(P< 0．05)，and the proportion of ts strab~s of RSV in oatu re was appro ximately the e from l987 to 1992． Prelim inary experiments showed tha t the rmruraily occurring ts strains of RSV are genetically stable．
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      Selection and Preliminary Characterization of Naturally Occurring Temperature—Sensitive Strains of Respir=ory Syncyfial Virus(RSV)

      • 1. Dep. of Clinical 

      Abstract: Seventeen naturally occurring B strains of RSV selected directly from 73 strains circulating in nature． The ts character was exam ined by parallel plaque assay and reexam ined three times for each strain．Based oi"1 the 33℃ ／39．5℃ 1gPFU difference，the RSV circulating strains could be divided into three groups of strain，namely．Our study suggested that there a more naturally 0e curring ts strains arnmag the subtype B RSV than am ng subtype A(P< 0．05)，and the proportion of ts strab~s of RSV in oatu re was appro ximately the e from l987 to 1992． Prelim inary experiments showed tha t the rmruraily occurring ts strains of RSV are genetically stable．

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